Hypersexuality in men with prolactinomas treated with dopamine agonists

Excerpt

Prolactinoma is the most common hypersecreting tumor of pituitary gland [1] and medical therapy with dopamine agonists (DAs) is recommended as first line intervention. DA therapy is effective in reversing hyperprolactinemia and its consequences—secondary hypogonadism and galactorrhea and may induce tumor shrinkage [2]. DA, such as cabergoline and bromocriptine, lead to prolactin normalization by acting through D2 receptors on the lactotroph cells. In many cases DA therapy is necessary for extended period of time, even life-long. While more common side effects of DAs such as headaches, dizziness and gastrointestinal disturbance are well known, a less recognized side effect of DA therapy is development of impulse control disorders (ICDs). …