Top

Published in:

Open Access 01-08-2015 | Rhinosinusitis (J Mullol, Section Editor)

Hypersensitivity to Aspirin and other NSAIDs: Diagnostic Approach in Patients with Chronic Rhinosinusitis

Authors: Joanna Makowska, Anna Lewandowska–Polak, Marek L. Kowalski

Published in: Current Allergy and Asthma Reports | Issue 8/2015

Abstract

Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) associated with chronic rhinosinusitis (CRS) and/or asthma comprises a distinct clinical syndrome referred to as NSAIDs exacerbated respiratory disease (NERD). Patients with NERD tend to have more severe course of both upper (CRS and nasal polyps) and lower airway (asthma) diseases and are usually recalcitrant to conventional treatment modalities. Diagnosing and phenotyping of patients with NERD are critical for prevention of drug-induced adverse reactions and open novel options for management of underlying chronic airway inflammatory diseases. Diagnosis of NERD is based on detailed clinical history confirmed by challenge with aspirin, but new diagnostic approaches are currently being developed. This review article focuses on the diagnostic approach to a patient with CRS and hypersensitivity to NSAIDs, emphasizing the importance of diagnosis for proper patient’s management.

Kowalski ML, Makowska JS, Blanca M, Bavbek S, Bochenek G, Bousquet J, et al. Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs)—classification, diagnosis and management: review of the EAACI/ENDA(#) and GA2LEN/HANNA*. Allergy. 2011;66:818–29.PubMedCrossRef

2.•

Kowalski ML, Asero R, Bavbek S, Blanca M, Blanca-Lopez N, Bochenek G, et al. Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs. Allergy. 2013;68:1219–32. This is position paper of Drug Allergy section proposing novel classification of NSAIDs hypersensitivity reactions.PubMedCrossRef

Rajan JP, Wineinger NE, Stevenson DD, White AA. Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: A meta-analysis of the literature. J Allergy Clin Immunol. 2015;135:676–81.

4.•

Mullol J, Picado C. Rhinosinusitis and nasal polyps in aspirin-exacerbated respiratory disease. Immunol Allergy Clin N Am. 2013;33:163–76. This review summarizes management recommended in patients with rhinosinusitis and hypersensitivity to NSAIDs.CrossRef

Casadevall J, Ventura PJ, Mullol J, Picado C. Intranasal challenge with aspirin in the diagnosis of aspirin intolerant asthma: evaluation of nasal response by acoustic rhinometry. Thorax. 2000;55:921–4.PubMedCentralPubMedCrossRef

Berges-Gimeno MP, Simon RA, Stevenson DD. The natural history and clinical characteristics of aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol. 2002;89:474–8.PubMedCrossRef

Szczeklik A, Nizankowska E, Duplaga M. Natural history of aspirin-induced asthma. AIANE Investigators. European Network on Aspirin-Induced Asthma. Eur Respir J. 2000;16:432–6.PubMedCrossRef

Bavbek S, Dursun B, Dursun E, Korkmaz H, Sertkaya KD. The prevalence of aspirin hypersensitivity in patients with nasal polyposis and contributing factors. Am J Rhinol Allergy. 2011;25:411–5.PubMedCrossRef

Awad OG, Lee JH, Fasano MB, Graham SM. Sinonasal outcomes after endoscopic sinus surgery in asthmatic patients with nasal polyps: a difference between aspirin-tolerant and aspirin-induced asthma? Laryngoscope. 2008;118:1282–6.PubMedCrossRef

10.

Kowalski ML, Bienkiewicz B, Kordek P. Nasal polyposis in aspirin-hypersensitive patients with asthma (aspirin triad) and aspirin-tolerant patients. Allergy Clin Immunol Int - J World Allergy Org. 2003;6:246–50.

11.

Kowalski ML. Aspirin-sensitive rhinosinusitis and asthma. Clin Allergy Immunol. 2007;19:147–75.PubMed

12.

Lewandowska-Polak A, Jedrzejczak-Czechowicz M, Makowska JS, Jarzebska M, Jankowski A, Kowalski ML. Lack of association between aspirin-triggered 15-hydroxyeicosatetraenoic acid release and mast cell/eosinophil activation in nasal polyps from aspirin-sensitive patients. J Investig Allergol Clin Immunol. 2011;21:507–13.PubMed

13.

Szczeklik A, Gryglewski RJ, Czerniawska-Mysik G, Zmuda A. Aspirin-induced asthma. Hypersensitivity to fenoprofen and ibuprofen in relation to their inhibitory action on prostaglandin generation by different microsomal enzymic preparations. J Allergy Clin Immunol. 1976;58:10–8.PubMedCrossRef

14.

Szczeklik A, Sanak M. The broken balance in aspirin hypersensitivity. Eur J Pharmacol. 2006;533:145–55.PubMedCrossRef

15.•

Roca-Ferrer J, Garcia-Garcia FJ, Pereda J, Perez-Gonzalez M, Pujols L, Alobid I, et al. Reduced expression of COXs and production of prostaglandin E(2) in patients with nasal polyps with or without aspirin-intolerant asthma. J Allergy Clin Immunol. 2011;128:66–72 e1. The study compares expression of COX-1, COX-2 and expression of prostaglandin E receptors on fibroblast from nasal polyps of aspirin tolerant and hypersensitive patients.PubMedCrossRef

16.

Varga EM, Jacobson MR, Masuyama K, Rak S, Till SJ, Darby Y, et al. Inflammatory cell populations and cytokine mRNA expression in the nasal mucosa in aspirin-sensitive rhinitis. Eur Respir J. 1999;14:610–5.PubMedCrossRef

17.

Picado C. Mechanisms of aspirin sensitivity. Curr Allergy Asthma Rep. 2006;6:198–202.PubMedCrossRef

18.

Kowalski ML, Sliwinska-Kowalska M, Igarashi Y, White MV, Wojciechowska B, Brayton P, et al. Nasal secretions in response to acetylsalicylic acid. J Allergy Clin Immunol. 1993;91:580–98.PubMedCrossRef

19.

Kowalski ML, Pawliczak R, Wozniak J, Siuda K, Poniatowska M, Iwaszkiewicz J, et al. Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patients. Am J Respir Crit Care Med. 2000;161:391–8.PubMedCrossRef

20.

Kowalski ML, Ptasinska A, Bienkiewicz B, Pawliczak R, DuBuske L. Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients. J Allergy Clin Immunol. 2003;112:505–12.PubMedCrossRef

21.

Kowalski ML, Borowiec M, Kurowski M, Pawliczak R. Alternative splicing of cyclooxygenase-1 gene: altered expression in leucocytes from patients with bronchial asthma and association with aspirin-induced 15-HETE release. Allergy. 2007;62:628–34.PubMedCrossRef

22.

Cahill KN, Bensko JC, Boyce JA, Laidlaw TM. Prostaglandin D(2): a dominant mediator of aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2015;135:245–52.PubMedCrossRef

23.•

Laidlaw TM, Cutler AJ, Kidder MS, Liu T, Cardet JC, Chhay H, et al. Prostaglandin E2 resistance in granulocytes from patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2014;133:1692–701 e3. Study described impaired granulocyte function in AERD patients, which can lead to dysregulated control of 5-lipooxygenase by PGE2.PubMedCentralPubMedCrossRef

24.

Pods R, Ross D, van Hulst S, Rudack C, Maune S. RANTES, eotaxin and eotaxin-2 expression and production in patients with aspirin triad. Allergy. 2003;58:1165–70.PubMedCrossRef

25.

Kowalski ML, Grzegorczyk J, Pawliczak R, Kornatowski T, Wagrowska-Danilewicz M, Danilewicz M. Decreased apoptosis and distinct profile of infiltrating cells in the nasal polyps of patients with aspirin hypersensitivity. Allergy. 2002;57:493–500.PubMedCrossRef

26.

de Borja Callejas F, Picado C, Martinez-Anton A, Alobid I, Pujols L, Valero A, et al. Differential expression of remodeling markers by tissue structure in nasal polyposis. Am J Rhinol Allergy. 2013;27:e69–74.PubMedCrossRef

27.

Steinke JW, Liu L, Huyett P, Negri J, Payne SC, Borish L. Prominent role of IFN-gamma in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2013;132:856–65 e1-3.PubMedCentralPubMedCrossRef

28.

Kowalski ML, Lewandowska-Polak A, Wozniak J, Ptasinska A, Jankowski A, Wagrowska-Danilewicz M, et al. Association of stem cell factor expression in nasal polyp epithelial cells with aspirin sensitivity and asthma. Allergy. 2005;60:631–7.PubMedCrossRef

29.

Pawankar R, Lee KH, Nonaka M, Takizawa R. Role of mast cells and basophils in chronic rhinosinusitis. Clin Allergy Immunol. 2007;20:93–101.PubMed

30.

Bochenek G, Nagraba K, Nizankowska E, Szczeklik A. A controlled study of 9alpha,11beta-PGF2 (a prostaglandin D2 metabolite) in plasma and urine of patients with bronchial asthma and healthy controls after aspirin challenge. J Allergy Clin Immunol. 2003;111:743–9.PubMedCrossRef

31.

Adamusiak AM, Stasikowska-Kanicka O, Lewandowska-Polak A, Danilewicz M, Wagrowska-Danilewicz M, Jankowski A, et al. Expression of arachidonate metabolism enzymes and receptors in nasal polyps of aspirin-hypersensitive asthmatics. Int Arch Allergy Immunol. 2012;157:354–62.PubMedCrossRef

32.

Nasser SM, Pfister R, Christie PE, Sousa AR, Barker J, Schmitz-Schumann M, et al. Inflammatory cell populations in bronchial biopsies from aspirin-sensitive asthmatic subjects. Am J Respir Crit Care Med. 1996;153:90–6.PubMedCrossRef

33.

Picado C, Fernandez-Morata JC, Juan M, Roca-Ferrer J, Fuentes M, Xaubet A, et al. Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics. Am J Respir Crit Care Med. 1999;160:291–6.PubMedCrossRef

34.

Pujols L, Mullol J, Alobid I, Roca-Ferrer J, Xaubet A, Picado C. Dynamics of COX-2 in nasal mucosa and nasal polyps from aspirin-tolerant and aspirin-intolerant patients with asthma. J Allergy Clin Immunol. 2004;114:814–9.PubMedCrossRef

35.

Pierzchalska M, Szabo Z, Sanak M, Soja J, Szczeklik A. Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma. J Allergy Clin Immunol. 2003;111:1041–8.PubMedCrossRef

36.

Roca-Ferrer J, Perez-Gonzalez M, Garcia-Garcia FJ, Pereda J, Pujols L, Alobid I, et al. Low prostaglandin E2 and cyclooxygenase expression in nasal mucosa fibroblasts of aspirin-intolerant asthmatics. Respirology. 2013;18:711–7.PubMedCrossRef

37.

Ying S, Meng Q, Scadding G, Parikh A, Corrigan CJ, Lee TH. Aspirin-sensitive rhinosinusitis is associated with reduced E-prostanoid 2 receptor expression on nasal mucosal inflammatory cells. J Allergy Clin Immunol. 2006;117:312–8.PubMedCrossRef

38.

Corrigan CJ, Napoli RL, Meng Q, Fang C, Wu H, Tochiki K, et al. Reduced expression of the prostaglandin E2 receptor E-prostanoid 2 on bronchial mucosal leukocytes in patients with aspirin-sensitive asthma. J Allergy Clin Immunol. 2012;129:1636–46.PubMedCrossRef

39.

Perez-Novo CA, Watelet JB, Claeys C, Van Cauwenberge P, Bachert C. Prostaglandin, leukotriene, and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis. J Allergy Clin Immunol. 2005;115:1189–96.PubMedCrossRef

40.

Corrigan C, Mallett K, Ying S, Roberts D, Parikh A, Scadding G, et al. Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis. J Allergy Clin Immunol. 2005;115:316–22.PubMedCrossRef

41.

Dahlen B, Nizankowska E, Szczeklik A, Zetterstrom O, Bochenek G, Kumlin M, et al. Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. Am J Respir Crit Care Med. 1998;157:1187–94.PubMedCrossRef

42.

Ragab S, Parikh A, Darby YC, Scadding GK. An open audit of montelukast, a leukotriene receptor antagonist, in nasal polyposis associated with asthma. Clin Exp Allergy. 2001;31:1385–91.PubMedCrossRef

43.

Pawliczak R, Lewandowska-Polak A, Kowalski ML. Pathogenesis of nasal polyps: an update. Curr Allergy Asthma Rep. 2005;5:463–71.PubMedCrossRef

44.

Szczeklik A. Aspirin-induced asthma as a viral disease. Clin Allergy. 1988;18:15–20.PubMedCrossRef

45.

Perez-Novo CA, Kowalski ML, Kuna P, Ptasinska A, Holtappels G, van Cauwenberge P, et al. Aspirin sensitivity and IgE antibodies to Staphylococcus aureus enterotoxins in nasal polyposis: studies on the relationship. Int Arch Allergy Immunol. 2004;133:255–60.PubMedCrossRef

46.

Suh YJ, Yoon SH, Sampson AP, Kim HJ, Kim SH, Nahm DH, et al. Specific immunoglobulin E for staphylococcal enterotoxins in nasal polyps from patients with aspirin-intolerant asthma. Clin Exp Allergy. 2004;34:1270–5.PubMedCrossRef

47.

Kim SH, Sanak M, Park HS. Genetics of hypersensitivity to aspirin and nonsteroidal anti-inflammatory drugs. Immunol Allergy Clin N Am. 2013;33:177–94.CrossRef

48.

Kim JE, Kountakis SE. The prevalence of Samter's triad in patients undergoing functional endoscopic sinus surgery. Ear Nose Throat J. 2007;86:396–9.PubMed

49.

Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology. 2012;50:1–12.PubMed

50.

Alobid I, Benitez P, Cardelus S, de Borja CF, Lehrer-Coriat E, Pujols L, et al. Oral plus nasal corticosteroids improve smell, nasal congestion, and inflammation in sino-nasal polyposis. Laryngoscope. 2014;124:50–6.PubMedCrossRef

51.

Pleskow WW, Stevenson DD, Mathison DA, Simon RA, Schatz M, Zeiger RS. Aspirin-sensitive rhinosinusitis/asthma: spectrum of adverse reactions to aspirin. J Allergy Clin Immunol. 1983;71:574–9.PubMedCrossRef

52.

Bochenek G, Nizankowska E, Szczeklik A. The atopy trait in hypersensitivity to nonsteroidal anti-inflammatory drugs. Allergy. 1996;51:16–23.PubMedCrossRef

53.

Sanchez-Borges M, Capriles-Hulett A. Atopy is a risk factor for non-steroidal anti-inflammatory drug sensitivity. Ann Allergy Asthma Immunol. 2000;84:101–6.PubMedCrossRef

54.

Kalyoncu AF, Karakaya G, Sahin AA, Baris YI. Occurrence of allergic conditions in asthmatics with analgesic intolerance. Allergy. 1999;54:428–35.PubMedCrossRef

55.

Kupczyk M, Kuprys I, Gorski P, Kuna P. Aspirin intolerance and allergy to house dust mites: important factors associated with development of severe asthma. Ann Allergy Asthma Immunol. 2004;92:453–8.PubMedCrossRef

56.•

Stevenson DD, Kowalski ML. An epidemic of over diagnosing drug allergies. Allergy Asthma Proc. 2014;35:92–4. The paper underlines the importance of drug challenges to avoid overdiagnosis of hypersensitivty to NSAIDs and other drugs.PubMedCrossRef

57.

Dursun AB, Woessner KA, Simon RA, Karasoy D, Stevenson DD. Predicting outcomes of oral aspirin challenges in patients with asthma, nasal polyps, and chronic sinusitis. Ann Allergy Asthma Immunol. 2008;100:420–5.PubMedCrossRef

58.

Nizankowska E, Bestynska-Krypel A, Cmiel A, Szczeklik A. Oral and bronchial provocation tests with aspirin for diagnosis of aspirin-induced asthma. Eur Respir J. 2000;15:863–9.PubMedCrossRef

59.

Melillo G, Balzano G, Bianco S, Dahlen B, Godard P, Kowalsky ML, et al. Report of the INTERASMA Working Group on Standardization of Inhalation Provocation Tests in Aspirin-induced Asthma. Oral and inhalation provocation tests for the diagnosis of aspirin-induced asthma. Allergy. 2001;56:899–911.PubMedCrossRef

60.

Stevenson DD. Approach to the patient with a history of adverse reactions to aspirin or NSAIDs: diagnosis and treatment. Allergy Asthma Proc. 2000;21:25–31.PubMedCrossRef

61.

Cormican LJ, Farooque S, Altmann DR, Lee TH. Improvements in an oral aspirin challenge protocol for the diagnosis of aspirin hypersensitivity. Clin Exp Allergy. 2005;35:717–22.PubMedCrossRef

62.

Macy E, Bernstein JA, Castells MC, Gawchik SM, Lee TH, Settipane RA, et al. Aspirin challenge and desensitization for aspirin-exacerbated respiratory disease: a practice paper. Ann Allergy Asthma Immunol. 2007;98:172–4.PubMedCrossRef

63.

Nizankowska-Mogilnicka E, Bochenek G, Mastalerz L, Swierczynska M, Picado C, Scadding G, et al. EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity. Allergy. 2007;62:1111–8.PubMedCrossRef

64.

Szmidt M, Grzelewska-Rzymowska I, Kowalski ML, Rozniecki J. Tolerance to acetylsalicylic acid (ASA) induced in ASA-sensitive asthmatics does not depend on initial adverse reaction. Allergy. 1987;42:182–5.PubMedCrossRef

65.

Stevenson DD, Simon RA, Mathison DA, Christiansen SC. Montelukast is only partially effective in inhibiting aspirin responses in aspirin-sensitive asthmatics. Ann Allergy Asthma Immunol. 2000;85:477–82.PubMedCrossRef

66.

Berges-Gimeno MP, Simon RA, Stevenson DD. The effect of leukotriene-modifier drugs on aspirin-induced asthma and rhinitis reactions. Clin Exp Allergy. 2002;32:1491–6.PubMedCrossRef

67.

White A, Ludington E, Mehra P, Stevenson DD, Simon RA. Effect of leukotriene modifier drugs on the safety of oral aspirin challenges. Ann Allergy Asthma Immunol. 2006;97:688–93.PubMedCrossRef

68.

Milewski M, Mastalerz L, Nizankowska E, Szczeklik A. Nasal provocation test with lysine-aspirin for diagnosis of aspirin-sensitive asthma. J Allergy Clin Immunol. 1998;101:581–6.PubMedCrossRef

69.

Alonso-Llamazares A, Martinez-Cocera C, Dominguez-Ortega J, Robledo-Echarren T, Cimarra-Alvarez M, Mesa del Castillo M. Nasal provocation test (NPT) with aspirin: a sensitive and safe method to diagnose aspirin-induced asthma (AIA). Allergy. 2002;57:632–5.PubMedCrossRef

70.

Pawlowicz A, Williams WR, Davies BH. Inhalation and nasal challenge in the diagnosis of aspirin-induced asthma. Allergy. 1991;46:405–9.PubMedCrossRef

71.

Wellbrock M, Mertens J, Cornelius M, Brasch J. Intranasal provocation with lysine acetylsalicylic acid. HNO. 1993;41:577–81.PubMed

72.

Patriarca G, Nucera E, DiRienzo V, Schiavino D, Pellegrino S, Fais G. Nasal provocation test with lysine acetylsalicylate in aspirin-sensitive patients. Ann Allergy. 1991;67:60–2.PubMed

73.

Miller B, Mirakian R, Gane S, Larco J, Sannah AA, Darby Y, et al. Nasal lysine aspirin challenge in the diagnosis of aspirin—exacerbated respiratory disease: asthma and rhinitis. Clin Exp Allergy. 2013;43:874–80.PubMedCentralPubMedCrossRef

74.•

Munoz-Cano R, Bartra J, Sanchez-Lopez J, Picado C, Bissinger I, Valero A. Acoustic rhinometry and aspirin nasal challenge in the diagnosis of aspirin-intolerant asthma: clinical finding and safety aspects. Int Arch Allergy Immunol. 2013;160:307–12. Authors provide data on clinical safety of nasal challenge test with aspirin, which can be used even in patients with severe asthma.PubMedCrossRef

75.•

Wismol P, Putivoranat P, Buranapraditkun S, Pinnobphun P, Ruxrungtham K, Klaewsongkram J. The values of nasal provocation test and basophil activation test in the different patterns of ASA/NSAID hypersensitivity. Allergol Immunopathol (Madr). 2012;40:156–63.CrossRef

76.

Celikel S, Stevenson D, Erkorkmaz U, White AA. Use of nasal inspiratory flow rates in the measurement of aspirin-induced respiratory reactions. Ann Allergy Asthma Immunol. 2013;111:252–5.PubMedCrossRef

77.

Kupczyk M, Kuprys-Lipinska I, Bochenska-Marciniak M, Kuna P. Acoustic rhinometry in the evaluation of intranasal aspirin challenge. Pneumonol Alergol Pol. 2010;78:103–11.PubMed

78.

Lee DK, Haggart K, Lipworth BJ. Reproducibility of response to nasal lysine-aspirin challenge in patients with aspirin-induced asthma. Ann Allergy Asthma Immunol. 2004;93:185–8.PubMedCrossRef

79.

Celik G, Bavbek S, Misirligil Z, Melli M. Release of cysteinyl leukotrienes with aspirin stimulation and the effect of prostaglandin E(2) on this release from peripheral blood leucocytes in aspirin-induced asthmatic patients. Clin Exp Allergy. 2001;31:1615–22.PubMedCrossRef

80.

May A, Weber A, Gall H, Kaufmann R, Zollner TM. Means of increasing sensitivity of an in vitro diagnostic test for aspirin intolerance. Clin Exp Allergy. 1999;29:1402–11.PubMedCrossRef

81.

Sanz ML, Gamboa P, de Weck AL. A new combined test with flowcytometric basophil activation and determination of sulfidoleukotrienes is useful for in vitro diagnosis of hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs. Int Arch Allergy Immunol. 2005;136:58–72.PubMedCrossRef

82.

Abrahamsen O, Haas H, Schreiber J, Schlaak M. Differential mediator release from basophils of allergic and non-allergic asthmatic patients after stimulation with anti-IgE and C5a. Clin Exp Allergy. 2001;31:368–78.PubMedCrossRef

83.

Pierzchalska M, Mastalerz L, Sanak M, Zazula M, Szczeklik A. A moderate and unspecific release of cysteinyl leukotrienes by aspirin from peripheral blood leucocytes precludes its value for aspirin sensitivity testing in asthma. Clin Exp Allergy. 2000;30:1785–91.PubMedCrossRef

84.

Gray PA, Warner TD, Vojnovic I, Del Soldato P, Parikh A, Scadding GK, et al. Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors. Br J Pharmacol. 2002;137:1031–8.PubMedCentralPubMedCrossRef

85.

Erdmann SM, Ventocilla S, Moll-Slodowy S, Sauer I, Merk HF. Basophil activation tests in the diagnosis of drug reactions. Hautarzt. 2005;56:38–43.PubMedCrossRef

86.

Celik GE, Schroeder JT, Hamilton RG, Saini SS, Adkinson NF. Effect of in vitro aspirin stimulation on basophils in patients with aspirin-exacerbated respiratory disease. Clin Exp Allergy. 2009;39:1522–31.PubMedCentralPubMedCrossRef

87.

Bavbek S, Ikinciogullari A, Dursun AB, Guloglu D, Arikan M, Elhan AH, et al. Upregulation of CD63 or CD203c alone or in combination is not sensitive in the diagnosis of nonsteroidal anti-inflammatory drug intolerance. Int Arch Allergy Immunol. 2009;150:261–70.PubMedCrossRef

88.

Kowalski ML, Ptasinska A, Jedrzejczak M, Bienkiewicz B, Cieslak M, Grzegorczyk J, et al. Aspirin-triggered 15-HETE generation in peripheral blood leukocytes is a specific and sensitive Aspirin-Sensitive Patients Identification Test (ASPITest). Allergy. 2005;60:1139–45.PubMedCrossRef

89.

Korosec P, Tisler U, Bajrovic N, Silar M, Mrhar A, Kosnik M. Acetylsalicylic acid-triggered 15-HETE generation by peripheral leukocytes for identifying ASA sensitivity. Respir Med. 2011;105 Suppl 1:S81–3.PubMedCrossRef

90.

James A, Daham K, Backman L, Brunnstrom A, Tingvall T, Kumlin M, et al. The influence of aspirin on release of eoxin C4, leukotriene C4 and 15-HETE, in eosinophilic granulocytes isolated from patients with asthma. Int Arch Allergy Immunol. 2013;162:135–42.PubMedCrossRef

91.

Higashi N, Taniguchi M, Mita H, Osame M, Akiyama K. A comparative study of eicosanoid concentrations in sputum and urine in patients with aspirin-intolerant asthma. Clin Exp Allergy. 2002;32:1484–90.PubMedCrossRef

92.

Misso NL, Aggarwal S, Phelps S, Beard R, Thompson PJ. Urinary leukotriene E4 and 9 alpha, 11 beta-prostaglandin F concentrations in mild, moderate and severe asthma, and in healthy subjects. Clin Exp Allergy. 2004;34:624–31.PubMedCrossRef

93.

Higashi N, Taniguchi M, Mita H, Kawagishi Y, Ishii T, Higashi A, et al. Clinical features of asthmatic patients with increased urinary leukotriene E4 excretion (hyperleukotrienuria): Involvement of chronic hyperplastic rhinosinusitis with nasal polyposis. J Allergy Clin Immunol. 2004;113:277–83.PubMedCrossRef

94.

Sanak M, Gielicz A, Bochenek G, Kaszuba M, Nizankowska-Mogilnicka E, Szczeklik A. Targeted eicosanoid lipidomics of exhaled breath condensate provide a distinct pattern in the aspirin-intolerant asthma phenotype. J Allergy Clin Immunol. 2011;127:1141–7.PubMedCrossRef

95.

Park SM, Park JS, Park HS, Park CS. Unraveling the genetic basis of aspirin hypersensitivity in asthma beyond arachidonate pathways. Allergy Asthma Immunol Res. 2013;5:258–76.PubMedCentralPubMedCrossRef

96.

Dekker JW, Nizankowska E, Schmitz-Schumann M, Pile K, Bochenek G, Dyczek A, et al. Aspirin-induced asthma and HLA-DRB1 and HLA-DPB1 genotypes. Clin Exp Allergy. 1997;27:574–7.PubMedCrossRef

97.

Choi JH, Lee KW, Oh HB, Lee KJ, Suh YJ, Park CS, et al. HLA association in aspirin-intolerant asthma: DPB1*0301 as a strong marker in a Korean population. J Allergy Clin Immunol. 2004;113:562–4.PubMedCrossRef

98.

Park HS, Kim SH, Sampson AP, Lee KW, Park CS. The HLA-DPB1*0301 marker might predict the requirement for leukotriene receptor antagonist in patients with aspirin-intolerant asthma. J Allergy Clin Immunol. 2004;114:688–9.PubMedCrossRef

99.

Kim SH, Cho BY, Choi H, Shin ES, Ye YM, Lee JE, et al. The SNP rs3128965 of HLA-DPB1 as a genetic marker of the AERD phenotype. PLoS One. 2014;9, e111220.PubMedCentralPubMedCrossRef

Title: Hypersensitivity to Aspirin and other NSAIDs: Diagnostic Approach in Patients with Chronic Rhinosinusitis
Authors: Joanna Makowska
Anna Lewandowska–Polak
Marek L. Kowalski
Publication date: 01-08-2015
Publisher: Springer US
Published in: Current Allergy and Asthma Reports / Issue 8/2015
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-015-0552-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Hypersensitivity to Aspirin and other NSAIDs: Diagnostic Approach in Patients with Chronic Rhinosinusitis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 8/2015

The Future of Sublingual Immunotherapy in the United States

Food Protein-Induced Enterocolitis Syndrome, Allergic Proctocolitis, and Enteropathy

Role of Rhinopharyngoscopy in Diagnosis of Rhinopathies

Hymenoptera Anaphylaxis and C-kit Mutations: An Unexpected Association

Erratum to: Technological Innovations for High-Throughput Approaches to In Vitro Allergy Diagnosis

Humoral Primary Immunodeficiencies in Chronic Rhinosinusitis