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Acta Neuropathologica
Published in: Acta Neuropathologica 6/2003

01-12-2003 | Regular Paper

Hyperproliferation of synapses on spinal motor neurons of Duchenne muscular dystrophy and myotonic dystrophy patients

Authors: Masahiro Nagao, Shuichi Kato, Hideaki Hayashi, Hidemi Misawa

Published in: Acta Neuropathologica | Issue 6/2003

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Abstract

Synapses on the motor neurons of patients with Duchenne muscular dystrophy (DMD) and myotonic dystrophy (MD) were studied immunohistochemically using antibodies against synaptobrevin and synaptophysin. Some motor neurons showed hyperproliferation of synapses on the soma and the proximal dendrites. Hyperproliferated synapses were non-cholinergic, because they were not identified with antibodies against vesicular acetylcholine transporter. Regeneration of motor nerve terminals in patients with muscular diseases may affect reorganization of the subsets of central synapses.
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Metadata
Title
Hyperproliferation of synapses on spinal motor neurons of Duchenne muscular dystrophy and myotonic dystrophy patients
Authors
Masahiro Nagao
Shuichi Kato
Hideaki Hayashi
Hidemi Misawa
Publication date
01-12-2003
Publisher
Springer-Verlag
Published in
Acta Neuropathologica / Issue 6/2003
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-003-0759-1

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