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Neurology and Therapy
Published in: Neurology and Therapy 4/2023

Open Access 02-06-2023 | Hyperglycemia | ORIGINAL RESEARCH

Association Between Admission Hyperglycemia and Outcomes After Endovascular Treatment in Acute Basilar Artery Occlusion

Authors: Lijiao Zhang, Fei Gao, Yaoyu Tian, Linyu Li, Yan Tian, Changwei Guo, Dahong Yang, Chengsong Yue, Jiaxing Song, Wenjie Zi, Jia Li, Zhenqian Liu

Published in: Neurology and Therapy | Issue 4/2023

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Abstract

Introduction

Admission hyperglycemia and high admission blood glucose levels have been associated with poor outcomes in acute ischemic stroke. However, the relationship between admission hyperglycemia and outcomes after endovascular treatment (EVT) in acute basilar artery occlusion (ABAO) still remain unclear. This study aimed to investigate the association between admission hyperglycemia and clinical outcomes in ABAO following EVT.

Methods

Patients from the BASILAR registry with admission blood glucose levels treated with EVT were included. We defined admission hyperglycemia as blood glucose levels ≥ 7.8 mmol/L. The primary outcome was favorable outcome [defined as a modified Rankin Scale score (mRS) of 0–3] at 90 days, Secondary outcomes included other functional outcomes (mRS 0–2, mRS 0–1) at 90 days, symptomatic intracerebral hemorrhage (sICH) within 48 h, and mortality at 90 days.

Results

Of 545 eligible patients included, the median age was 65 (IQR, 56–73) years, and median blood glucose level was 7.36 (IQR, 6.10–9.66) mmol/L. Multivariable logistic regression analysis showed that admission hyperglycemia was associated with decreased favorable outcome (mRS 0–3) (adjusted odds ratio = 0.52; 95% CI 0.35–0.79; P = 0.001), and increased mortality (adjusted odds ratio = 2.67; 95% CI 1.82–3.91; P < 0.001). Restricted cubic spline regression analysis showed that the blood glucose level had a non-linearity association with favorable outcome and mortality, and that there was no association between admission hyperglycemia and sICH.

Conclusions

Our study suggest that admission hyperglycemia is associated with an increased risk of poor functional outcomes and mortality in patients with ABAO treated with EVT.

Trial Registration

Chinese Clinical Trial Registry (http://​www.​chictr.​org.​cn), ChiCTR180001475.
Appendix
Available only for authorised users
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Metadata
Title
Association Between Admission Hyperglycemia and Outcomes After Endovascular Treatment in Acute Basilar Artery Occlusion
Authors
Lijiao Zhang
Fei Gao
Yaoyu Tian
Linyu Li
Yan Tian
Changwei Guo
Dahong Yang
Chengsong Yue
Jiaxing Song
Wenjie Zi
Jia Li
Zhenqian Liu
Publication date
02-06-2023
Publisher
Springer Healthcare
Published in
Neurology and Therapy / Issue 4/2023
Print ISSN: 2193-8253
Electronic ISSN: 2193-6536
DOI
https://doi.org/10.1007/s40120-023-00502-8

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