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01-09-2014 | Original Article

Hyperglycemia 3 Days After Esophageal Cancer Surgery Is Associated with an Increased Risk of Postoperative Infection

Authors: Naoko Ito, Takeshi Iwaya, Kenichiro Ikeda, Yusuke Kimura, Yuji Akiyama, Masafumi Konosu, Kaoru Ishida, Hisataka Fujiwara, Koki Otsuka, Hiroyuki Nitta, Masahiro Kashiwaba, Keisuke Koeda, Satoshi Nishizuka, Masaru Mizuno, Akira Sasaki, Go Wakabayashi

Published in: Journal of Gastrointestinal Surgery | Issue 9/2014

Abstract

Purpose

Postoperative hyperglycemia is associated with infectious complications after various types of surgery. Our objective was to determine whether postoperative blood glucose levels up to 1 week after highly invasive esophageal cancer surgery are associated with the incidence of postoperative infections (POIs).

Methods

We conducted a retrospective chart review of 109 consecutive thoracic esophageal squamous cell cancer patients who underwent invasive esophagectomy with thoracotomy and laparotomy. The incidence of postoperative POIs and risk factors for POIs, including postoperative blood glucose levels, were evaluated.

Results

Of the 109 patients, 37 (34.0 %) developed POIs. Clinically, 73.0 % of the POIs became evident on or after postoperative day 4 (median, 5.25 days; interquartile range, 3.00–9.25 days). On and after postoperative day 3, chronological changes in blood glucose levels were significantly different between two groups of patients with or without POIs, as indicated by repeated measures ANOVA (P = 0.006). Multivariate logistic regression analysis results showed that an increased blood glucose concentration on postoperative day 3 was a significant risk factor for POIs.

Conclusions

Our findings suggested that postoperative hyperglycemia on postoperative day 3 was a predictive factor of POIs after highly invasive esophageal cancer surgery.

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Title: Hyperglycemia 3 Days After Esophageal Cancer Surgery Is Associated with an Increased Risk of Postoperative Infection
Authors: Naoko Ito
Takeshi Iwaya
Kenichiro Ikeda
Yusuke Kimura
Yuji Akiyama
Masafumi Konosu
Kaoru Ishida
Hisataka Fujiwara
Koki Otsuka
Hiroyuki Nitta
Masahiro Kashiwaba
Keisuke Koeda
Satoshi Nishizuka
Masaru Mizuno
Akira Sasaki
Go Wakabayashi
Publication date: 01-09-2014
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 9/2014
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-014-2587-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Hyperglycemia 3 Days After Esophageal Cancer Surgery Is Associated with an Increased Risk of Postoperative Infection

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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