Top

Published in:

Open Access 01-12-2014 | Case report

Hypereosinophilia in childhood acute lymphoblastic leukaemia at diagnosis: report of 2 cases and review of the literature

Authors: Rosanna Parasole, Fara Petruzziello, Antonia De Matteo, Giovanna Maisto, Luisa Castelli, Maria Elena Errico, Giuseppe Menna, Vincenzo Poggi

Published in: Italian Journal of Pediatrics | Issue 1/2014

Abstract

Hypereosinophilia as first clinical presentation has rarely been reported in paediatric acute lymphoblastic leukaemia. It is commonly associated with specific cytogenetic abnormalities. Although eosinophilia is considered a reactive, non-neoplastic epiphenomenon, it adversely affects patient outcomes, both in children and adults. We describe herewith two paediatric patients who had marked eosinophilia at onset of acute lymphoblastic leukaemia. We point out the importance of a correct differential diagnosis in persistent, unexplained peripheral hypereosinophilia. Clinicians should keep in mind that eosinophilia can be part of the overall pattern of acute leukaemia and therefore needs to be properly investigated. We also provide some recommendations for an appropriate approach to hypereosinophilia - related morbidities.

Available only for authorised users

Bhatti FA, Hussain I, Alì MZ: Adult B lymphoblastic leukemia/lymphoma with hypodiploidy (-9) and a novel chromosomal translocation t(7;12)(q22;p13) presenting with severe eosinophilia – case report and review of literature. J Hematol Oncol. 2009, 2: 26-10.1186/1756-8722-2-26.PubMedCentralCrossRefPubMed

Spitzer G, Garson OM: Lymphoblastic leukemia with marked eosinophilia: a report of two cases. Blood. 1973, 42: 377-384.PubMed

Bae SY, Yoon S-Y, Huh JH, Sung HJ, Choi IK: Hypereosinophilia in biphenotypic (B-cell/T-cell) acute lymphoblastic leukemia. Leuk Lymphoma. 2007, 48: 1417-1419. 10.1080/10428190701361836.CrossRefPubMed

Wynn TT, Heerema NA, Hammond S, Ranalli M, Kahwash SB: Acute lymphoblastic leukemia with hypereosinophilia: report of a case with 5q deletion and review of the literature. Pediatr Dev Pathol. 2003, 6: 558-563.CrossRefPubMed

Ayhan AC, Timur C, Ayhan Y, Cakır B, Erguven M: Does hypereosinophilic syndrome precede common B acute lymphoblastic leukaemia in childhood? A case report. Acta Haematol. 2011, 127: 90-92.CrossRefPubMed

Sutton R, Lonergan M, Tapp H, Venn NC, Haber M, Norris MD, O’Brien TA, Alvaro F, Revesz T: Two cases of hypereosinophilia and high-risk acute lymphoblastic leukemia. Leukemia. 2008, 22: 1463-1465. 10.1038/sj.leu.2405096.CrossRefPubMed

D’Angelo G, Hotz AM, Todeschin P: Acute lymphoblastic leukemia with hypereosinophilia and 9p21 deletion: case report and review of the literature. Lab Hematol. 2008, 14 (1): 7-9. 10.1532/LH96.07018.CrossRefPubMed

Wilson F, Tefferi A: Acute lymphocytic leukemia with eosinophilia: two case reports and a literature review. Leuk Lymphoma. 2005, 46 (7): 1045-1050. 10.1080/10428190500085537.CrossRefPubMed

Hogan TF, Koss W, Murgo AJ, Amato RS, Fontana JA, VanScoy FL: Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review. J Clin Oncol. 1987, 5: 382-390.PubMed

10.

Utsunomiya A, Ishida T, Inagaki A, Ishii T, Yano H, Komatsu H, Iida S, Yonekura K, Takeuchi S, Takatsuka Y, Ueda R: Clinical significance of a blood eosinophilia in adult T-cell leukemia/lymphoma: a blood eosinophilia is a significant unfavourable prognostic factor. Leuk Res. 2007, 31: 915-920. 10.1016/j.leukres.2006.10.017.CrossRefPubMed

11.

Gotlib J, Cools J, Malone JM, Schrier SL, Gilliland DG, Coutré SE: The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management. Blood. 2004, 103: 2879-2891. 10.1182/blood-2003-06-1824.CrossRefPubMed

12.

Conter V, Bartram CR, Valsecchi MG, Schrauder A, Panzer-Grümayer R, Möricke A, Aricò M, Zimmermann M, Mann G, De Rossi G, Stanulla M, Locatelli F, Basso G, Niggli F, Barisone E, Henze G, Ludwig WD, Haas OA, Cazzaniga G, Koehler R, Silvestri D, Bradtke J, Parasole R, Beier R, van Dongen JJ, Biondi A, Schrappe M: Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL2000 study. Blood. 2010, 115: 3206-3214. 10.1182/blood-2009-10-248146.CrossRefPubMed

13.

van der Velden VHJ, Cazzaniga G, Shrauder A, Hancock J, Bader P, Panzer-Grumayer ER, Flohr T, Sutton R, Cave H, Madsen HO, Cayuela JM, Trka J, Eckert C, Foroni L, Zur Stadt U, Beldjord K, Raff T, van der Schoot CE, van Dongen JJ, European Study Group on MRD detection in ALL (ESG-MRD-ALL): Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative data. Leukemia. 2007, 21: 604-611.PubMed

14.

Grimaldi JC, Meeker TC: The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene. Blood. 1989, 73: 2081-2085.PubMed

15.

Rezamand A, Ghorashi Z, Ghorashi S, Nezami N: Eosinophilic presentation of acute lymphoblastic leukemia. Am J Case Rep. 2013, 14: 143-146.PubMedCentralCrossRefPubMed

16.

Rezk S, Wheelock L, Fletcher JA, Oliveira AM, Keuker CP, Newburger PE, Xu B, Woda BA, Miron PM: Acute lymphocytic leukemia with eosinophilia and unusual karyotype. Leuk Lymphoma. 2006, 47: 1176-1179. 10.1080/10428190500508710.CrossRefPubMed

17.

Rios-Herranz E, Fores-Cachon R, Diez-Martin SL, Fernandez MN: Hypereosinophilia and acute lymphocytic leukaemia. Postgrad Med J. 1991, 67: 702-703.PubMedCentralCrossRefPubMed

18.

Rapanotti MC, Caruso R, Ammatuna E, Zaza S, Trotta L, Divona M, Cicconi L, Funaro D, Federici G, Amadori S, De Rossi G, Lo-Coco F: Molecular characterization of paediatric idiopathic hypereosinophilia. Br J Haematol. 2010, 151 (5): 440-446. 10.1111/j.1365-2141.2010.08394.x.CrossRefPubMed

19.

Williams E, Smart SC, Go RS: Catastrophic thromboembolism in a patient with acute lymphoblastic leukemia and hypereosinophilia. Haematologica. 2004, 89: e15-

20.

Girodon F, Bergoin E, Favre B, Martha SA, Mugneret F, Couillault G, Carli PM, Maynadié M: Hypereosinophilia in acute B-lineage lymphoblastic leukemia. Br J Haematol. 2005, 129: 568-10.1111/j.1365-2141.2005.05469.x.CrossRefPubMed

Title: Hypereosinophilia in childhood acute lymphoblastic leukaemia at diagnosis: report of 2 cases and review of the literature
Authors: Rosanna Parasole
Fara Petruzziello
Antonia De Matteo
Giovanna Maisto
Luisa Castelli
Maria Elena Errico
Giuseppe Menna
Vincenzo Poggi
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Italian Journal of Pediatrics / Issue 1/2014
Electronic ISSN: 1824-7288
DOI: https://doi.org/10.1186/1824-7288-40-36

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Hypereosinophilia in childhood acute lymphoblastic leukaemia at diagnosis: report of 2 cases and review of the literature

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2014

Empirical validation of the “Pediatric Asthma Hospitalization Rate” indicator

Clinical heterogeneity of abnormal glucose homeostasis associated with the HNF4A R311H mutation

Arthrogryposis–renal dysfunction–cholestasis (ARC) syndrome: from molecular genetics to clinical features

Psychosocial, behavioural, pedagogical, and nutritional proposals about how to encourage eating a healthy breakfast

Maternal lifestyle factors in pregnancy and congenital heart defects in offspring: review of the current evidence

Congenital tuberculosis detected by T-SPOT.TB assay in a male infant after in vitro fertilization and followed up with radiography