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International Orthopaedics
Published in: International Orthopaedics 10/2011

01-10-2011 | Original Paper

Hydroxyapatite coating enhances polyethylene terephthalate artificial ligament graft osseointegration in the bone tunnel

Authors: Hong Li, Yunsheng Ge, Yang Wu, Jia Jiang, Kai Gao, Pengyun Zhang, Lingxiang Wu, Shiyi Chen

Published in: International Orthopaedics | Issue 10/2011

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Abstract

The purpose of this study was to investigate whether hydroxyapatite (HAp) coating could induce polyethylene terephthalate (PET) artificial ligament graft osseointegration in the bone tunnel. Twenty-four New Zealand white rabbits underwent artificial ligament graft transplantation in bilateral proximal tibia tunnels. One limb was implanted with HAp-coated PET graft, and the contralateral limb was implanted with non-HAp-coated PET graft as control. The rabbits were randomly sacrificed at four and eight weeks after surgery. The loads to failure of the experimental group at eight weeks were significantly higher than those of the control group (p = 0.0057). Histologically, application of HAp coating induced new bone formation between graft and bone at eight weeks compared with the controls. Real-time polymerase chain reaction examination revealed significantly elevated messenger ribonucleic acid expression levels of osteopontin and collagen I in the grafts of the HAp group compared with the controls at four weeks (p < 0.05). The study has shown that HAp coating on the PET artificial ligament surface has a positive effect in the induction of artificial ligament osseointegration within the bone tunnel.
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Metadata
Title
Hydroxyapatite coating enhances polyethylene terephthalate artificial ligament graft osseointegration in the bone tunnel
Authors
Hong Li
Yunsheng Ge
Yang Wu
Jia Jiang
Kai Gao
Pengyun Zhang
Lingxiang Wu
Shiyi Chen
Publication date
01-10-2011
Publisher
Springer-Verlag
Published in
International Orthopaedics / Issue 10/2011
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-010-1158-6

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