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01-06-2020 | Short Communication

Hydrogel-Based Therapy for Brain Repair After Intracerebral Hemorrhage

Authors: Teck Chuan Lim, Emiri Mandeville, Ding Weng, Li-Shan Wang, Motoichi Kurisawa, Kimberly Leite-Morris, Magdy H. Selim, Eng H. Lo, Myron Spector

Published in: Translational Stroke Research | Issue 3/2020

Abstract

We assessed an injectable gelatin hydrogel containing epidermal growth factor (Gtn-EGF) as a therapy for intracerebral hemorrhage (ICH). ICH was induced in rats via collagenase injection into the striatum. Two weeks later, Gtn-EGF was injected into the cavitary lesion. The hydrogel filled ICH cavities without deforming brain tissue. Immunostaining demonstrated that neural precursor cells could migrate into the matrix, and some of these differentiated into neurons along with the appearance of astrocytes, oligodendrocytes, and endothelial cells. Sensorimotor tests suggested that Gtn-EGF improved neurological recovery. This study provides proof-of-principle that injectable biomaterials may be a translationally relevant approach for treating ICH.

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Title: Hydrogel-Based Therapy for Brain Repair After Intracerebral Hemorrhage
Authors: Teck Chuan Lim
Emiri Mandeville
Ding Weng
Li-Shan Wang
Motoichi Kurisawa
Kimberly Leite-Morris
Magdy H. Selim
Eng H. Lo
Myron Spector
Publication date: 01-06-2020
Publisher: Springer US
Published in: Translational Stroke Research / Issue 3/2020
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-019-00721-y

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Springer Medicine

Hydrogel-Based Therapy for Brain Repair After Intracerebral Hemorrhage

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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