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01-10-2021 | Hydrocephalus | Case Report

Tectocerebellar dysraphia and occipital encephalocele associated with trisomy X: case report and review of the literature

Authors: Lissa C. Goulart, Luiz A. Ferreira-Filho, Mariana M. da Silva, Israel S. B. Carneiro, Siderley S. Carneiro, Osvaldo Vilela-Filho

Published in: Child's Nervous System | Issue 10/2021

Abstract

Introduction

Tectocerebellar dysraphia (TCD) is a rare sporadic malformation associated with severe neurodevelopmental morbidity and high infant mortality. The presence of other ciliopathies worsens the prognosis. Joubert syndrome (JS) is a ciliopathy associated with gene mutations, consisting of midbrain and cerebellum malformations, markedly lack fiber decussation at the level of the pontomesencephalic junction.

Case report

We report the case of a child who was born term with occipital encephalocele (OE), diagnosed with TCD and JS spectrum through computed tomography (CT), magnetic resonance (MR), diffuse tensor imaging (DTI), and clinical findings. She had the OE surgically corrected after spontaneous rupture on the second day after delivery. She developed postoperative ventriculitis, meningitis, and hydrocephalus, successfully treated with intravenous antibiotics and cysto-ventriculostomy, cysto-cisternostomy, third ventriculostomy, and choroid plexus coagulation. G-band karyotyping showed 47, XXX, in all analyzed cells (trisomy X). The infant was followed up for 18 months, presenting, so far, a relatively good outcome.

Conclusion

This is the first case reported in the literature of the association of TCD/OE/JS spectrum (JSS) with trisomy X (XXX).

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Title: Tectocerebellar dysraphia and occipital encephalocele associated with trisomy X: case report and review of the literature
Authors: Lissa C. Goulart
Luiz A. Ferreira-Filho
Mariana M. da Silva
Israel S. B. Carneiro
Siderley S. Carneiro
Osvaldo Vilela-Filho
Publication date: 01-10-2021
Publisher: Springer Berlin Heidelberg
Keywords: Hydrocephalus
Hydrocephalus
Encephalocele
Hydrocephalus
Trisomy
Published in: Child's Nervous System / Issue 10/2021
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-020-04989-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Tectocerebellar dysraphia and occipital encephalocele associated with trisomy X: case report and review of the literature

Abstract

Introduction

Case report

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Case report

Conclusion

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