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Child's Nervous System

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01-06-2021 | Hydrocephalus | Original Article

Predictor of a permanent shunt after treatment of external ventricular draining in pediatric postinfective hydrocephalus—a retrospective cohort study

Authors: Yi Zhang, Rui Zhao, Wei Shi, JiCui Zheng, Hao Li, ZhiHua Li

Published in: Child's Nervous System | Issue 6/2021

Abstract

Purpose

To assess the therapeutic efficacy of external ventricular draining (EVD) and to predict the need for permanent shunts in infants with postinfective hydrocephalus (PIHC).

Methods

This is a retrospective study of infants diagnosed with PIHC and treated by EVD between January 2013 and December 2017 at the Children’s Hospital of Fudan University. Clinical, laboratory, and imaging data were collected and analyzed to identify independent risk factors by logistic regression analyses. The predictor was evaluated using the area under the curve (AUC) of the receiver operating characteristic (ROC) curves.

Results

In total, 48 patients were identified, and 31 cases (64.5%) had a permanent shunt. EVD was effective in accelerating cerebrospinal fluid purification. In the permanent shunt group, the duration of EVD was significantly longer (28.5 ± 5.2 vs 14.9 ± 3.0 P < 0.05) and the frontal and occipital horn ratio (FOHR) at 7–10 days after EVD was significantly higher (0.57 ± 0.01 vs 0.48 ± 0.01 P < 0.001). The FOHR at 7–10 days after EVD predicts the need for a permanent shunt with an area under the ROC curve of 0.818.

Conclusion

EVD was effective for purification of CSF, whereas a permanent shunt was needed for more than half of the patients. The FOHR at 7–10 days after EVD may be a strong predictor for a permanent shunt.

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Title: Predictor of a permanent shunt after treatment of external ventricular draining in pediatric postinfective hydrocephalus—a retrospective cohort study
Authors: Yi Zhang
Rui Zhao
Wei Shi
JiCui Zheng
Hao Li
ZhiHua Li
Publication date: 01-06-2021
Publisher: Springer Berlin Heidelberg
Keywords: Hydrocephalus
Hydrocephalus
Hydrocephalus
CSF Drainage
Published in: Child's Nervous System / Issue 6/2021
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-021-05054-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Predictor of a permanent shunt after treatment of external ventricular draining in pediatric postinfective hydrocephalus—a retrospective cohort study

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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