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Open Access 01-12-2024 | Hydrocephalus | Research

Comparison of decline in different cognitive domain in patients with normal pressure hydrocephalus

Authors: Ondřej Rýdlo, Adéla Bubeníková, Klára Häcklová, Petr Skalický, Róbert Leško, Adéla Ebelová, David Netuka, Vladimír Beneš IIIrd, Vladimír Beneš, Ondřej Bradáč

Published in: Neurosurgical Review | Issue 1/2024

Abstract

We sought to describe the cognitive profile of patients with Idiopathic Normal Pressure Hydrocephalus (iNPH) using a comprehensive neuropsychological battery. Based on age and education correlated norms, we aimed to compare performance in each measured cognitive domain: executive functions (EFs), verbal memory (VM), non-verbal memory (nVM), visuoconstructional abilities (VA) and attention/psychomotor speed (A/PS). Patients diagnosed with iNPH underwent comprehensive neuropsychological evaluation before shunting. Their performance was compared to the age and education correlated norms. Correlation of different cognitive domains in iNPH profile was performed. A total of 53 iNPH patients (73.21 ± 5.48 years) were included in the study. All of the measured cognitive domains were significantly damaged. The most affected domains were EFs and VM (p<0.001 and p<0.001, respectively). A/PS domain was affected milder than EFs and VM (p<0.001). The least affected domains were nVM (p<0.001) and VA (p<0.001). Patients with iNPH are affected in all cognitive domains and the cognitive decline is uneven across these domains. The impairment of memory was shown to depend on the presented material. VM was shown to be much more severely affected than nVM and along with VM, EFs were shown to be the most affected. A/PS speed was shown to be less affected than VM and EFs and the least affected domains were nVM and VA.

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Title: Comparison of decline in different cognitive domain in patients with normal pressure hydrocephalus
Authors: Ondřej Rýdlo
Adéla Bubeníková
Klára Häcklová
Petr Skalický
Róbert Leško
Adéla Ebelová
David Netuka
Vladimír Beneš IIIrd
Vladimír Beneš
Ondřej Bradáč
Publication date: 01-12-2024
Publisher: Springer Berlin Heidelberg
Keywords: Hydrocephalus
Hydrocephalus
Hydrocephalus
Alzheimer's Disease
Alzheimer's Disease
Published in: Neurosurgical Review / Issue 1/2024
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI: https://doi.org/10.1007/s10143-024-02410-3

At a glance: The STEP trials

Springer Medicine

Comparison of decline in different cognitive domain in patients with normal pressure hydrocephalus

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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