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01-07-2021 | Hydrocephalus | Original Article - CSF Circulation

Clinical significance of vitamin D in idiopathic normal pressure hydrocephalus

Authors: Chaejin Lee, Hyunwoo Seo, Sang-Youl Yoon, Sung Hyun Chang, Seong-Hyun Park, Jeong-Hyun Hwang, Kyunghun Kang, Chi-Hun Kim, Myong Hun Hahm, Eunhee Park, Jae Yun Ahn, Ki-Su Park

Published in: Acta Neurochirurgica | Issue 7/2021

Abstract

Background

Although recent studies show vitamin D deficiency is associated with cognitive decline, urinary incontinence, and gait instability, there has been no study on the effect of vitamin D on idiopathic normal pressure hydrocephalus (iNPH) characterized by the classic symptom triad of cognitive decline, urinary incontinence, and gait instability. We investigated the clinical significance of vitamin D in patients with iNPH.

Methods

Between 2017 and 2020, 44 patients who underwent ventriculoperitoneal shunt surgery were divided into low (< 15 ng/mL) and high (≥ 15 ng/mL) vitamin D groups according to the concentration of 25(OH)D, an effective indicator of vitamin D status. They were respectively evaluated according to clinical and radiological findings.

Results

The low vitamin D group (n = 24) showed lower preoperative cognition compared to the high vitamin D group (n = 20) in terms of Korean-Mini Mental Status Examination (K-MMSE) and iNPH grading scale (iNPHGS) (K-MMSE: 20.5 ± 5.4 versus 24.0 ± 4.5, p = 0.041; iNPHGS cognitive score: 2 ± 0.9 versus 1 ± 0.6, p = 0.025). And the low vitamin D group showed pre- and postoperatively more severe urinary incontinence (preoperative iNPHGS urinary score: 1 ± 1.0 versus 0 ± 0.9, p = 0.012; postoperative iNPHGS urinary score:1 ± 1.0 versus 0 ± 0.9, p = 0.014). The score of narrow high-convexity sulci for the low vitamin D group was lower (low vitamin D group: 1 ± 0.7 versus high vitamin D group: 2 ± 0.4, p = 0.031).

Conclusion

Lower concentration of vitamin D in iNPH may be related to lower preoperative cognition, pre- and postoperative urinary incontinence, and brain morphological change.

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Title: Clinical significance of vitamin D in idiopathic normal pressure hydrocephalus
Authors: Chaejin Lee
Hyunwoo Seo
Sang-Youl Yoon
Sung Hyun Chang
Seong-Hyun Park
Jeong-Hyun Hwang
Kyunghun Kang
Chi-Hun Kim
Myong Hun Hahm
Eunhee Park
Jae Yun Ahn
Ki-Su Park
Publication date: 01-07-2021
Publisher: Springer Vienna
Keywords: Hydrocephalus
Hydrocephalus
Hydrocephalus
Urinary Incontinence
Urinary Incontinence
Published in: Acta Neurochirurgica / Issue 7/2021
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-021-04849-5

At a glance: The STEP trials

Springer Medicine

Clinical significance of vitamin D in idiopathic normal pressure hydrocephalus

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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