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01-03-2005 | Original Article

Hyaluronan synthase expression in pleural malignant mesotheliomas

Authors: Naoki Kanomata, Tomoyuki Yokose, Tomoyuki Kamijo, Hiroyuki Yonou, Takahiro Hasebe, Naoki Itano, Koji Kimata, Atsushi Ochiai

Published in: Virchows Archiv | Issue 3/2005

Abstract

Hyaluronan (HA) is thought to play several important roles in tumor growth, tumorigenicity, and tumor dissemination and metastasis. Recently, three isoforms of hyaluronan synthase (HAS) have been cloned. Our objective was to determine which of the HAS isoforms were expressed in pleural malignant mesotheliomas, the most representative lesion of HA-producing tumors. We studied 10 cases of pleural malignant mesothelioma using novel antibodies of HAS. We compared HAS expression patterns of mesothelioma and pulmonary adenocarcinoma. Immunohistochemically, 9 of 10 (90%) cases of mesothelioma had extensive reaction to anti-HAS1 and anti-HAS2 antibodies, while HAS3 overexpression was present in 4 of 10 cases (40%). Of 20 cases of pulmonary adenocarcinoma, 5 overexpressed HAS1 (25%), 16 of 20 HAS2 (80%), and 4 of 20 HAS3 (20%). The expression level of HAS1 was significantly higher in mesotheliomas than in pulmonary adenocarcinoma (P=0.0036). Our data suggests that HAS1 might be a useful positive marker of malignant mesothelioma. However, a definitive conclusion should be based on further large-scale studies.

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Title: Hyaluronan synthase expression in pleural malignant mesotheliomas
Authors: Naoki Kanomata
Tomoyuki Yokose
Tomoyuki Kamijo
Hiroyuki Yonou
Takahiro Hasebe
Naoki Itano
Koji Kimata
Atsushi Ochiai
Publication date: 01-03-2005
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 3/2005
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-004-1197-8

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Hyaluronan synthase expression in pleural malignant mesotheliomas

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