Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
BMC Cancer
Published in: BMC Cancer 1/2018

Open Access 01-12-2018 | Research article

Human papillomavirus infection in patients with laryngeal carcinoma

Authors: Ozlem Onerci Celebi, Ebru Sener, Sefik Hosal, Mustafa Cengiz, Ibrahim Gullu, Gaye Guler Tezel

Published in: BMC Cancer | Issue 1/2018

Login to get access

Abstract

Background

The aim of this study was to determine the HPV positivity rate in patients with laryngeal cancer, and to determine the effect of HPV positivity on survival. An additional aim was to determine if patients with HPV positive laryngeal cancer are more sensitive to chemotherapy and if such sensitivity differs according to chemotherapy protocol.

Methods

The study included laryngeal specimens obtained from 82 laryngeal cancer patients and 11 laryngeal specimens with normal laryngeal mucosa that were obtained from our hospital’s paraffin block archives between 1995 and 2013. HPV was detected via chromogenic in situ hybridization (cISH) and confirmed via genotyping.

Results

HPV was not detected in any of the 82 laryngeal cancer patients’ laryngeal specimens, nor in any of the 11 archived laryngeal specimens with normal laryngeal mucosa via cISH. Genotyping confirmed these findings; none of the HPV types studied were detected in any of the specimens. As none of the study samples were HPV positive, it was not possible to compare survival, recurrence, or chemotherapy sensitivity.

Conclusions

HPV infection is not a leading cause of laryngeal cancer; however, additional research on HPV positivity in patients with laryngeal cancer and its effect on recurrence, survival, and chemotherapy sensitivity is warranted.
Literature
1.
Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49:1374–403.CrossRef
2.
Mohamadian Roshan N, Jafarian A, Ayatollahi H, Ghazvini K, Tabatabaee SA. Correlation of laryngeal squamous cell carcinoma and infections with either HHV-8 or HPV-16/18. Pathol Res Pract. 2014;210:205–9.CrossRef
3.
Schwartz SR, Yueh B, McDougall JK, Daling JR, Schwartz SM. Human papillomavirus infection and survival in oral squamous cell cancer: a population-based study. Otolaryngol Head Neck Surg. 2001;125:1–9.CrossRef
4.
Fakhry C, Gillison ML. Clinical implications of human papillomavirus in head and neck cancers. J Clin Oncol. 2006;24:2606–11.CrossRef
5.
Kumar B, Cordell KG, Lee JS, Prince ME, Tran HH, Wolf GT, Urba SG, Worden FP, Chepeha DB, Teknos TN, Eisbruch A, Tsien CI, Taylor JM, D'Silva NJ, Yang K, Kurnit DM, Bradford CR, Carey TE. Response to therapy and outcomes in oropharyngeal cancer are associated with biomarkers including human papillomavirus, epidermal growth factor receptor, gender, and smoking. Int J Radiat Oncol Biol Phys. 2007;69:S109–11.CrossRef
6.
Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tan PF, Westra WH, Chung CH, Jordan RC, Lu C, Kim H, Axelrod R, Silverman CC, Redmond KP, Gillison ML. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010;363:24–35.CrossRef
7.
Stephen JK, Chen KM, Shah V, Havard S, Lu M, Schweitzer VP, Gardner G, Worsham MJ. Human papillomavirus outcomes in an access-to-care laryngeal cancer cohort. Otolaryngol Head Neck Surg. 2012;146:730–8.CrossRef
8.
Clayman GL, Stewart MG, Weber RS, el-Naggar AK, Grimm EA. Human papillomavirus in laryngeal and hypopharyngeal carcinomas. Relationship to survival. Arch Otolaryngol Head Neck Surg. 1994;120:743–8.CrossRef
9.
Morshed K. Association between human papillomavirus infection and laryngeal squamous cell carcinoma. J Med Virol. 2010;82:1017–23.CrossRef
10.
Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L, Zahurak ML, Daniel RW, Viglione M, Symer DE, Shah KV, Sidransky D. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst. 2000;92:709–20.CrossRef
11.
Torrente MC, Rodrigo JP, Haigentz M Jr, Dikkers FG, Rinaldo A, Takes RP, Olofsson J, Ferlito A. Human papillomavirus infections in laryngeal cancer. Head Neck. 2011;33:581–6.CrossRef
12.
Torrente MC, Ojeda JM. Exploring the relation between human papilloma virus and larynx cancer. Acta Otolaryngol. 2007;127:900–6.CrossRef
13.
Schache AG, Liloglou T, Risk JM, Filia A, Jones TM, Sheard J, Woolgar JA, Helliwell TR, Triantafyllou A, Robinson M, Sloan P, Harvey-Woodworth C, Sisson D, Shaw RJ. Evaluation of human papilloma virus diagnostic testing in oropharyngeal squamous cell carcinoma: sensitivity, specificity, and prognostic discrimination. Clin Cancer Res. 2011;17:6262–71.CrossRef
14.
Low HC, Silver MI, Brown BJ, Leng CY, Blas MM, Gravitt PE, Woo YL. Comparison of Hybribio GenoArray and Roche human papillomavirus (HPV) linear array for HPV genotyping in anal swab samples. J Clin Microbiol. 2015;53:550–6.CrossRef
15.
Gallo A, Degener AM, Pagliuca G, Pierangeli A, Bizzoni F, Greco A, de Vincentiis M. Detection of human papillomavirus and adenovirus in benign and malignant lesions of the larynx. Otolaryngol Head Neck Surg. 2009;141:276–81.CrossRef
16.
Lindeberg H, Krogdahl A. Laryngeal cancer and human papillomavirus: HPV is absent in the majority of laryngeal carcinomas. Cancer Lett. 1999;146:9–13.CrossRef
17.
Morgan DW, Abdullah V, Quiney R, Myint S. Human papilloma virus and carcinoma of the laryngopharynx. J Laryngol Otol. 1991;105:288–90.CrossRef
18.
19.
Stevens TM, Caughron SK, Dunn ST, Knezetic J, Gatalica Z. Detection of high-risk HPV in head and neck squamous cell carcinomas: comparison of chromogenic in situ hybridization and a reverse line blot method. Appl Immunohistochem Mol Morphol. 2011;19:574–8.CrossRef
20.
Termine N, Panzarella V, Falaschini S, Russo A, Matranga D, Lo Muzio L, Campisi G (2008) HPV in oral squamous cell carcinoma vs head and neck squamous cell carcinoma biopsies: a meta-analysis (1988-2007). Ann Oncol 2008; 19:1681–1690.CrossRef
21.
Ha PK, Pai SI, Westra WH, Gillison ML, Tong BC, Sidransky D, Califano JA. Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral cavity. Clin Cancer Res. 2002;8:1203–9.PubMed
22.
Huang CC, Qiu JT, Kashima ML, Kurman RJ, Wu TC. Generation of type-specific probes for the detection of single-copy human papillomavirus by a novel in situ hybridization method. Mod Pathol. 1998;11:971–7.PubMed
23.
Gheit T, Abedi-Ardekani B, Carreira C, Missad CG, Tommasino M, Torrente MC. Comprehensive analysis of HPV expression in laryngeal squamous cell carcinoma. J Med Virol. 2014;86:642–6.CrossRef
24.
Guvenc MG, Midilli K, Ozdogan A, Inci E, Tahamiler R, Enver O, Sirin G, Ergin S, Kuskucu M, Divanoglu EO, Yilmaz G, Altas K. Detection of HHV-8 and HPV in laryngeal carcinoma. Auris Nasus Larynx. 2008;35:357–62.CrossRef
25.
26.
Gungor A, Cincik H, Baloglu H, Cekin E, Dogru S, Dursun E. Human papilloma virus prevalence in laryngeal squamous cell carcinoma. J Laryngol Otol. 2007;121:772–4.CrossRef
Metadata
Title
Human papillomavirus infection in patients with laryngeal carcinoma
Authors
Ozlem Onerci Celebi
Ebru Sener
Sefik Hosal
Mustafa Cengiz
Ibrahim Gullu
Gaye Guler Tezel
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-018-4890-8

Other articles of this Issue 1/2018

BMC Cancer 1/2018 Go to the issue

Research article

Docetaxel facilitates lymphatic-tumor crosstalk to promote lymphangiogenesis and cancer progression

Research article

Prognostic significance of supradiaphragmatic lymph node metastasis detected by 18F-FDG PET/CT in advanced epithelial ovarian cancer

Case report

Itraconazole treatment of primary malignant melanoma of the vagina evaluated using positron emission tomography and tissue cDNA microarray: a case report

Research article

Optimal cutoff of pretreatment neutrophil-to-lymphocyte ratio in head and neck cancer patients: a meta-analysis and validation study

Research article

Predictors of adverse pathologic features after radical prostatectomy in low-risk prostate cancer

Debate

To fast, or not to fast before chemotherapy, that is the question
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits