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Immunologic Research
Published in: Immunologic Research 2-3/2011

01-12-2011 | Current Immunology Research at Jefferson

Human immune system mice: current potential and limitations for translational research on human antibody responses

Authors: Raja Vuyyuru, John Patton, Tim Manser

Published in: Immunologic Research | Issue 2-3/2011

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Abstract

It has recently become possible to generate chimeric mice durably engrafted with many components of the human immune system (HIS mice). We have characterized the maturation and function of the B cell compartment of HIS mice. The antibody response of HIS mice to T cell-dependent B cell antigens is limited, and contributing factors may be the general immaturity of the B cell compartment, infrequent helper T cells selected on human MHC class II antigens, and incomplete reconstitution of secondary lymphoid organs and their microenvironments. In contrast, HIS mice generate protective antibody responses to the bacterium Borrelia hermsii, which acts as a T cell-independent antigen in mice, but do not respond to purified polysaccharide antigens (PPS). We speculate that the anti-B. hermsii response of HIS mice is derived from an abundant B cell subset that may be analogous to B1 B cells in mice. We suggest that failure of HIS mice to respond to PPS is due to the lack of a B cell subset that may originate from adult bone marrow and is highly dependent on human interleukin-7 for development.
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Metadata
Title
Human immune system mice: current potential and limitations for translational research on human antibody responses
Authors
Raja Vuyyuru
John Patton
Tim Manser
Publication date
01-12-2011
Publisher
Humana Press Inc
Published in
Immunologic Research / Issue 2-3/2011
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-011-8243-9

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