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BMC Pregnancy and Childbirth
Published in: BMC Pregnancy and Childbirth 1/2024

Open Access 01-12-2024 | Human Cytomegalovirus | Research

Hygiene-based measures for the prevention of cytomegalovirus infection in pregnant women: a systematic review

Authors: María F. Rodríguez-Muñoz, Clara Martín-Martín, Katina Kovacheva, Maria Eugenia Olivares, Nuria Izquierdo, Pilar Pérez-Romero, Estéfani García-Ríos

Published in: BMC Pregnancy and Childbirth | Issue 1/2024

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Abstract

Background

Human Cytomegalovirus (HCMV) is the most frequent congenital infection worldwide causing important sequelae. However, no vaccine or antiviral treatments are currently available, thus interventions are restricted to behavioral measures. The aim of this systematic review was to assess evidence from available intervention studies using hygiene-based measures to prevent HCMV infection during pregnancy.

Methods

Studies published from 1972 to 2023 were searched in Medline, PsycInfo, and Clinical Trials (PROSPERO, CRD42022344840) according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Methodological quality was assessed by two authors, using ROBE-2 and MINORS.

Results

After reviewing 6 selected articles, the outcome analysis suggested that implementation of hygiene-based interventions during pregnancy prevent, to some extent, the acquisition of congenital HCMV.

Conclusions

However, these conclusions are based on limited and low-quality evidence available from few studies using this type of intervention in clinical practice. Thus, it would be necessary to perform effective and homogeneous intervention studies using hygiene-based measures, evaluated in high-quality randomized controlled trials (RCTs).
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Metadata
Title
Hygiene-based measures for the prevention of cytomegalovirus infection in pregnant women: a systematic review
Authors
María F. Rodríguez-Muñoz
Clara Martín-Martín
Katina Kovacheva
Maria Eugenia Olivares
Nuria Izquierdo
Pilar Pérez-Romero
Estéfani García-Ríos
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Pregnancy and Childbirth / Issue 1/2024
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/s12884-024-06367-5

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