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European Journal of Medical Research

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Open Access 01-12-2023 | Human Alphaherpesvirus 3 | Research

Resveratrol: a potential medication for the prevention and treatment of varicella zoster virus-induced ischemic stroke

Authors: Xu Wang, Hao Chen, Feiyu Song, Kuiyang Zuo, Xin Chen, Xu Zhang, Lanqian Liang, Qiyi Ta, Lin Zhang, Jinhua Li

Published in: European Journal of Medical Research | Issue 1/2023

Abstract

Background

Infection rate of varicella zoster virus (VZV) is 95% in humans, and VZV infection is strongly associated with ischemic stroke (IS). However, the underlying molecular mechanisms of VZV-induced IS are still unclear, and there are no effective agents to treat and prevent VZV-induced IS.

Objective

By integrating bioinformatics, this study explored the interactions between VZV and IS and potential medication to treat and prevent VZV-induced IS.

Methods

In this study, the VZV and IS datasets from the GEO database were used to specify the common genes. Then, bioinformatics analysis including Gene Ontology, Kyoto Encyclopedia Genes Genomes and Protein–Protein Interaction network analysis was performed. Further, the hub genes, transcription factor (TF) gene interactions, TF-miRNA co-regulatory network and potential drug were obtained. Finally, validation was performed using molecular docking and molecular dynamics simulations.

Results

The potential molecular mechanisms of VZV-induced IS were studied using multiple bioinformatics tools. Ten hub genes were COL1A2, DCN, PDGFRB, ACTA2, etc. TF genes and miRNAs included JUN, FOS, CREB, BRCA1, PPARG, STAT3, miR-29, etc. A series of mechanism may be involved, such as inflammation, oxidative stress, blood–brain barrier disruption, foam cell generation and among others. Finally, we proposed resveratrol as a potential therapeutic medicine for the prevention and treatment of VZV-induced IS. Molecular docking and molecular dynamics results showed that resveratrol and hub genes exhibited strong binding score.

Conclusions

Resveratrol could be an alternative for the prevention and treatment of VZV-IS. More in vivo and in vitro studies are needed in the future to fully explore the molecular mechanisms between VZV and IS and for medication development.

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Title: Resveratrol: a potential medication for the prevention and treatment of varicella zoster virus-induced ischemic stroke
Authors: Xu Wang
Hao Chen
Feiyu Song
Kuiyang Zuo
Xin Chen
Xu Zhang
Lanqian Liang
Qiyi Ta
Lin Zhang
Jinhua Li
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Human Alphaherpesvirus 3
Stroke
Arterial Occlusive Disease
Published in: European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-023-01291-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Resveratrol: a potential medication for the prevention and treatment of varicella zoster virus-induced ischemic stroke

Abstract

Background

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objective

Methods

Results

Conclusions

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