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Published in: BMC Infectious Diseases 1/2024

Open Access 01-12-2024 | Human Alphaherpesvirus 3 | Case Report

Kaposi varicelliform eruption: an unusual presentation caused by varicella zoster virus in a healthy adult patient - a case report

Authors: Hassan El-Masry, Safia Essam, Hamed Gaber, Nour Shaheen, Ahmed Abdelbary, Naglaa Mohamed Sayed, Salma Samir Omar

Published in: BMC Infectious Diseases | Issue 1/2024

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Abstract

Background

Kaposi Varicelliform Eruptions (KVE), also known as eczema herpeticum, is a rare and potentially life-threatening dermatological condition primarily attributed to herpes simplex virus (HSV) infection, with less frequent involvement of Coxsackie A16, vaccinia, Varicella Zoster, and smallpox viruses. Typically associated with pre-existing skin diseases, especially atopic dermatitis, KVE predominantly affects children but can manifest in healthy adults. Characterized by painful clusters of vesicles and sores on the skin and mucous membranes, it often masquerades as other dermatological disorders. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain relief and inflammation, though their potential role as KVE triggers remains uncertain.

Case report

Here, we present a case of an 18-year-old female with KVE attributed to Varicella Zoster virus (VZV) and successfully treated with oral acyclovir within a week, underscoring the significance of early recognition and intervention. KVE can manifest with systemic symptoms like fever, fatigue, and lymphadenopathy and may involve multiple organ systems, necessitating possible antibiotic use for complications.

Conclusion

This case underscores the importance of prompt KVE identification and consideration of antiviral therapy to enhance patient outcomes. Further research is warranted to elucidate predisposing factors for this rare condition.
Literature
2.
go back to reference Wollenberg A, Zoch C, Wetzel S, Plewig G, Przybilla B. Predisposing factors and clinical features of eczema herpeticum: a retrospective analysis of 100 cases. J Am Acad Dermatol. 2003;49(2):198–205.CrossRefPubMed Wollenberg A, Zoch C, Wetzel S, Plewig G, Przybilla B. Predisposing factors and clinical features of eczema herpeticum: a retrospective analysis of 100 cases. J Am Acad Dermatol. 2003;49(2):198–205.CrossRefPubMed
3.
go back to reference Min Z, Gnann JW. Kaposi’s varicelliform eruption. Vol. 9, Internal and Emergency Medicine. 2014. p. 101–2. Min Z, Gnann JW. Kaposi’s varicelliform eruption. Vol. 9, Internal and Emergency Medicine. 2014. p. 101–2.
5.
go back to reference Cardones AR. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. Clin Dermatol. 2020;38(6):702–11.CrossRefPubMed Cardones AR. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. Clin Dermatol. 2020;38(6):702–11.CrossRefPubMed
7.
go back to reference Gilden D, Nagel M, Cohrs R, Mahalingam R, Baird N. Varicella Zoster Virus in the nervous system. F1000Res. 2015;4:1356.CrossRef Gilden D, Nagel M, Cohrs R, Mahalingam R, Baird N. Varicella Zoster Virus in the nervous system. F1000Res. 2015;4:1356.CrossRef
8.
go back to reference Cheung EV, Tidball JG. Administration of the non-steroidal anti-inflammatory drug ibuprofen increases macrophage concentrations but reduces necrosis during modified muscle use. Inflamm Res. 2003;52(4):170–6.CrossRefPubMed Cheung EV, Tidball JG. Administration of the non-steroidal anti-inflammatory drug ibuprofen increases macrophage concentrations but reduces necrosis during modified muscle use. Inflamm Res. 2003;52(4):170–6.CrossRefPubMed
9.
go back to reference Giagoudakis G, Markantonis SL. Relationships between the concentrations of prostaglandins and the nonsteroidal antiinflammatory drugs Indomethacin, Diclofenac, and Ibuprofen. Pharmacotherapy. 2005;25(1):18–25.CrossRefPubMed Giagoudakis G, Markantonis SL. Relationships between the concentrations of prostaglandins and the nonsteroidal antiinflammatory drugs Indomethacin, Diclofenac, and Ibuprofen. Pharmacotherapy. 2005;25(1):18–25.CrossRefPubMed
10.
go back to reference Mikaeloff Y, Kezouh A, Suissa S. Nonsteroidal anti-inflammatory drug use and the risk of severe skin and soft tissue complications in patients with varicella or zoster disease. Br J Clin Pharmacol. 2008;65(2):203–9.CrossRefPubMed Mikaeloff Y, Kezouh A, Suissa S. Nonsteroidal anti-inflammatory drug use and the risk of severe skin and soft tissue complications in patients with varicella or zoster disease. Br J Clin Pharmacol. 2008;65(2):203–9.CrossRefPubMed
Metadata
Title
Kaposi varicelliform eruption: an unusual presentation caused by varicella zoster virus in a healthy adult patient - a case report
Authors
Hassan El-Masry
Safia Essam
Hamed Gaber
Nour Shaheen
Ahmed Abdelbary
Naglaa Mohamed Sayed
Salma Samir Omar
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2024
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-024-09115-4

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