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Open Access 01-12-2008 | Research article

HPV type infection in different anogenital sites among HIV-positive Brazilian women

Authors: Maria Alice G Gonçalves, Giorgia Randi, Annie Arslan, Luisa L Villa, Marcelo N Burattini, Silvia Franceschi, Eduardo Antonio Donadi, Eduardo Massad

Published in: Infectious Agents and Cancer | Issue 1/2008

Abstract

Objectives

To evaluate the prevalence of human papillomavirus (HPV) types, and risk factors for HPV positivity across cervix, vagina and anus, we conducted a study among 138 women with human immunodeficiency virus (HIV).

Goal

Compare the prevalence of different HPV types and the risk factors for HPV positivity in three sites.

Results

The most frequently detected HPV types in all sites were, in decreasing order, HPV16, 53, 18, 61 and 81. Agreement between the cervix and vagina was good (kappa 0.60 – 0.80) for HPV16 and 53 and excellent (Kappa > 0.80) for HPV18 and 61. HPV positivity was inversely associated with age for all combinations including the anal site.

Conclusion

In HIV positive women, HPV18 is the most spread HPV type found in combinations of anal and genital sites. The relationship of anal to genital infection has implications for the development of anal malignancies. Thus, the efficacy of the current HPV vaccine may be considered not only for the cervix, but also for prevention of HPV18 anal infection among immunossuppressed individuals.

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Title: HPV type infection in different anogenital sites among HIV-positive Brazilian women
Authors: Maria Alice G Gonçalves
Giorgia Randi
Annie Arslan
Luisa L Villa
Marcelo N Burattini
Silvia Franceschi
Eduardo Antonio Donadi
Eduardo Massad
Publication date: 01-12-2008
Publisher: BioMed Central
Published in: Infectious Agents and Cancer / Issue 1/2008
Electronic ISSN: 1750-9378
DOI: https://doi.org/10.1186/1750-9378-3-5

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Abstract

Objectives

Goal

Results

Conclusion

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