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International Journal of Colorectal Disease

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01-02-2013 | Original Article

hPEBP4 as a predictive marker for the pathological response of rectal cancer to preoperative radiotherapy

Authors: Jianming Qiu, Guangen Yang, Zhong Shen, Ya Xie, Lewei Wang

Published in: International Journal of Colorectal Disease | Issue 2/2013

Abstract

Purpose

The ability to predict tumor sensitivity toward radiotherapy is important in the personalized application of preoperative radiotherapy for patients with rectal cancer. The aim of the present study was to test the human phosphatidylethanolamine-binding protein 4 (hPEBP4) as a predictive marker of tumor response to preoperative radiotherapy in patients with rectal cancer.

Method

A retrospective analysis was conducted, consisting of 86 patients with locally advanced rectal cancer who underwent short-course preoperative radiotherapy (20 Gy in five fractions for 1 week) followed by a radical resection. Both pretreatment biopsy specimens and resected primary tumor tissue were collected. Immunohistochemistry and tumor regression grading system were used to evaluate the expression of hPEBP4 in the pretreatment biopsy specimens and the response of rectal cancer to radiotherapy, respectively. Expression of hPEBP4 was correlated with tumor regression in the resected specimen and the clinical outcome of the patients as well.

Results

We found that high expression of hPEBP4 was associated with radioresistance in both univariate and multivariate analyses, and patients with a high hPEBP4 expression had a poorer progression-free survival than those with low hPEBP4 expression.

Conclusion

Our study revealed the independent predictive values of hPEBP4 in response of rectal cancer to preoperative radiotherapy, which suggests that upregulating hPEBP4 might be a potential mechanism by which rectal cancer cells avoid the destructive effects of radiotherapy.

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Title: hPEBP4 as a predictive marker for the pathological response of rectal cancer to preoperative radiotherapy
Authors: Jianming Qiu
Guangen Yang
Zhong Shen
Ya Xie
Lewei Wang
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 2/2013
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-012-1534-3

At a glance: The STEP trials

Springer Medicine

hPEBP4 as a predictive marker for the pathological response of rectal cancer to preoperative radiotherapy

Abstract

Purpose

Method

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Method

Results

Conclusion

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