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01-11-2014 | How to Do It

How to successfully resect 70 % of the liver in pigs to model an extended hepatectomy with an insufficient remnant or liver transplantation with a small-for-size graft

Authors: Tomohide Hori, Shintaro Yagi, Yusuke Okamua, Taku Iida, Kohei Ogawa, Hirokazu Tanaka, Shoichi Kageyama, Hirofumi Hirao, Toshiyuki Hata, Izumi Kirino, Kazuyuki Nagai, Toyonari Kubora, Kanta Jobara, Kosuke Endo, Shinji Uemoto

Published in: Surgery Today | Issue 11/2014

Abstract

An insufficient remnant in extended hepatectomy and small-for-size graft in liver transplantation are critical matters in the field of liver surgery, and reliable and reproducible animal models that can provide clinically relevant and reliable data are needed. We herein describe our detailed surgical procedures for performing 70 % hepatectomy in pigs, and discuss the critical anatomical features, key techniques and pitfalls based on our experience. The porcine liver is divided into four lobes. The right lateral lobe (RLL) accounts for 30 % of the liver volume. Important points, such as selective temporal clamping of the arterial branch, confirmation of a related demarcation line, a two-step process to skeletonize Glisson’s capsules during liver resection and selective ligation of the portal venous branch to the right medial lobe without inducing any subtle injuries to Glisson’s capsules from the RLL to common bile duct, are discussed.

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Title: How to successfully resect 70 % of the liver in pigs to model an extended hepatectomy with an insufficient remnant or liver transplantation with a small-for-size graft
Authors: Tomohide Hori
Shintaro Yagi
Yusuke Okamua
Taku Iida
Kohei Ogawa
Hirokazu Tanaka
Shoichi Kageyama
Hirofumi Hirao
Toshiyuki Hata
Izumi Kirino
Kazuyuki Nagai
Toyonari Kubora
Kanta Jobara
Kosuke Endo
Shinji Uemoto
Publication date: 01-11-2014
Publisher: Springer Japan
Published in: Surgery Today / Issue 11/2014
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-014-0862-z

At a glance: The STEP trials

Springer Medicine

How to successfully resect 70 % of the liver in pigs to model an extended hepatectomy with an insufficient remnant or liver transplantation with a small-for-size graft

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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