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European Archives of Oto-Rhino-Laryngology

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01-07-2017 | Review Article

How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?

Authors: Fernando López, Michelle D. Williams, Antonio Cardesa, Jennifer L. Hunt, Primož Strojan, Alessandra Rinaldo, Iain J. Nixon, Juan P. Rodrigo, Nabil F. Saba, William M. Mendenhall, Miquel Quer, Carlos Suárez, Alfio Ferlito

Published in: European Archives of Oto-Rhino-Laryngology | Issue 7/2017

Abstract

Although the majority of laryngeal malignancies are the conventional squamous cell carcinomas (SCC), a wide variety of malignant epithelial tumors can affect the larynx. Current treatment guidelines are designed to guide clinicians in management of conventional laryngeal SCC. Less is known about the biological behavior and responsiveness to therapy and overall outcomes of other malignant epithelial lesions. Because a spectrum of disease biology is represented by these rare phenotypes, an understanding of the basic biology can help direct management to optimize clinical outcome in this group of patients. This review provides a critical analysis of literature relating to the diagnosis, management, and outcome of patients with non-conventional squamous malignant epithelial neoplasms of the larynx. Particular attention is paid to features which are at variance with the conventional SCC and how these impact on management of these rare tumors.

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Title: How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
Authors: Fernando López
Michelle D. Williams
Antonio Cardesa
Jennifer L. Hunt
Primož Strojan
Alessandra Rinaldo
Iain J. Nixon
Juan P. Rodrigo
Nabil F. Saba
William M. Mendenhall
Miquel Quer
Carlos Suárez
Alfio Ferlito
Publication date: 01-07-2017
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 7/2017
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-017-4533-8

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How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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