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Critical Care
Published in: Critical Care 4/2012

01-08-2012 | Commentary

How much fluid resuscitation is optimal in septic shock?

Author: James A Russell

Published in: Critical Care | Issue 4/2012

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Abstract

Smith and Perner report an observational cohort study of 164 patients with septic shock. For patients still alive on day 3, higher compared with lower fluid volume resuscitation was associated with lower 90-day mortality. This association of a relationship between fluid intake and decreased mortality aligns with the randomized controlled trial of early goal-directed therapy and later observational studies. I suggest careful individualization of fluid resuscitation to achieve adequate mean arterial pressure (about 60 to 70 mmHg) and normalization of arterial lactate levels in septic shock.

Trial registration

ISRCTN94845869
Literature
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Metadata
Title
How much fluid resuscitation is optimal in septic shock?
Author
James A Russell
Publication date
01-08-2012
Publisher
BioMed Central
Published in
Critical Care / Issue 4/2012
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc11393

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