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01-08-2013 | Review

How benign is hematuria? Using genetics to predict prognosis

Author: Daniel P. Gale

Published in: Pediatric Nephrology | Issue 8/2013

Abstract

Hematuria is a common presenting feature of glomerular disease and is sometimes associated with kidney failure later in life. Where isolated microscopic hematuria occurs in children and young adults, an underlying monogenic disorder, such as Alport syndrome or thin basement membrane nephropathy, is frequently responsible. In this review, these and other diseases, which often present with isolated microscopic hematuria, including hereditary angiopathy, nephropathy, aneurysms, and muscle cramps (HANAC) syndrome, IgA nephropathy, and CFHR5 nephropathy, are discussed together with the associated molecular pathology, clinical features, and prognosis. Genetic testing for these conditions used in clinical practice can provide important diagnostic and prognostic information that is relevant to the patient and their family, particularly when kidney transplantation is considered.

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Title: How benign is hematuria? Using genetics to predict prognosis
Author: Daniel P. Gale
Publication date: 01-08-2013
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 8/2013
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-012-2399-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

How benign is hematuria? Using genetics to predict prognosis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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