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Open Access 01-03-2015 | Systemic Diseases (M Bartold, Section Editor)

Host Responses in the Link Between Periodontitis and Rheumatoid Arthritis

Authors: Tetsuo Kobayashi, Hiromasa Yoshie

Published in: Current Oral Health Reports | Issue 1/2015

Abstract

Periodontitis and rheumatoid arthritis (RA) are common chronic inflammatory conditions and share many clinical and pathologic features. There is evidence to suggest that similar profiles of cytokine genotypes and their coding proteins are involved in the pathogenesis of periodontitis and RA. In particular, constitutive overproduction of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), has been implicated to play a pathologic role in the two inflammatory diseases. Results from studies with animal and human subjects have suggested an improvement of periodontal inflammatory condition after treatment with TNF-α inhibitors. Likewise, IL-6 receptor inhibition therapy has been suggested to have an effect on control of periodontal inflammation in patients with RA. In the present review, we provide an overview of studies showing the pathological role of cytokines in the linkage between periodontitis and RA, and further summarize the current studies assessing the effect of cytokine targeted therapy on periodontal condition.

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Kobayashi T, Okada M, Ito S, Kobayashi D, Ishida K, Kojima A, et al. Assessment of interleukin-6 receptor inhibition therapy on periodontal condition in patients with rheumatoid arthritis and chronic periodontitis. J Periodontol. 2014;85(1):57–67. This is the first study to demonstrate the efficacy of IL-6R inhibition therapy on periodontal inflammatory condition in patients with RA.PubMedCrossRef

Title: Host Responses in the Link Between Periodontitis and Rheumatoid Arthritis
Authors: Tetsuo Kobayashi
Hiromasa Yoshie
Publication date: 01-03-2015
Publisher: Springer International Publishing
Published in: Current Oral Health Reports / Issue 1/2015
Electronic ISSN: 2196-3002
DOI: https://doi.org/10.1007/s40496-014-0039-2

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Host Responses in the Link Between Periodontitis and Rheumatoid Arthritis

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Keynote webinar | Spotlight on medication adherence

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