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Breast Cancer Research
Published in: Breast Cancer Research 3/2003

01-06-2003 | Review

Host microenvironment in breast cancer development: Extracellular matrix–stromal cell contribution to neoplastic phenotype of epithelial cells in the breast

Authors: Malathy PV Shekhar, Robert Pauley, Gloria Heppner

Published in: Breast Cancer Research | Issue 3/2003

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Abstract

Epithelial–mesenchymal interactions play an important role both in normal mammary gland development and during neoplastic transformation. Perturbations in the production, deposition and degradation of the extracellular matrix occurring during neoplastic transformation and progression have been implicated to arise from alterations in the stromal response. These changes in the stroma exhibit a dominant regulatory role, via microenvironmental epigenetic effectors, to contribute to the development of the tumorigenic epithelial phenotype. The role of stromally derived microenvironmental epigenetic effectors in modulating epithelial growth, hormonal response, morphogenesis and epithelial plasticity is discussed.
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Metadata
Title
Host microenvironment in breast cancer development: Extracellular matrix–stromal cell contribution to neoplastic phenotype of epithelial cells in the breast
Authors
Malathy PV Shekhar
Robert Pauley
Gloria Heppner
Publication date
01-06-2003
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 3/2003
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr580

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