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Published in:

01-03-2015 | Review

Host genetics of invasive Aspergillus and Candida infections

Authors: Agnieszka Wójtowicz, Pierre-Yves Bochud

Published in: Seminars in Immunopathology | Issue 2/2015

Abstract

Invasive candidiasis and aspergillosis are major complications in surgical and onco-hematological patients, and still associated with an important morbidity and mortality. A large number of studies highlighted the potential role of host genetic polymorphisms that may influence susceptibility to fungal pathogens, but many were limited by insufficient statistical power, problematic design, and/or lack of replication. However, some relevant polymorphisms are now emerging from well-conducted studies whose associations have been replicated and/or are supported by strong biological evidence. Such polymorphisms together with other biomarkers may play a role in the prediction, diagnosis, and management of severe fungal infections in high-risk patients in the coming years.

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Title: Host genetics of invasive Aspergillus and Candida infections
Authors: Agnieszka Wójtowicz
Pierre-Yves Bochud
Publication date: 01-03-2015
Publisher: Springer Berlin Heidelberg
Published in: Seminars in Immunopathology / Issue 2/2015
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-014-0468-y

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