Skip to main content
Top
Published in: BMC Health Services Research 1/2007

Open Access 01-12-2007 | Research article

Hospital mortality in acute coronary syndrome: differences related to gender and use of percutaneous coronary procedures

Authors: María J Aguado-Romeo, Soledad Márquez-Calderón, María L Buzón-Barrera, the Medical Practice Variations Andalusian Group

Published in: BMC Health Services Research | Issue 1/2007

Login to get access

Abstract

Background

To identify differences among men and women with acute coronary syndrome in terms of in-hospital mortality, and to assess whether these differences are related to the use of percutaneous cardiovascular procedures.

Methods

Observational study based on the Minimum Basic Data Set. This encompassed all episodes of emergency hospital admissions (46,007 cases, including 16,391 women and 29,616 men) with a main diagnosis of either myocardial infarction or unstable angina at 32 hospitals within the Andalusian Public Health System over a four-year period (2000–2003). The relationship between gender and mortality was examined for the population as a whole and for stratified groups depending on the type of procedures used (diagnostic coronary catheterisation and/or percutaneous transluminal coronary angioplasty). These combinations were then adjusted for age group, main diagnosis and co-morbidityharlson score).

Results

During hospitalisation, mortality was 9.6% (4,401 cases out of 46,007), with 11.8% for women and 8.3% for men. There were more deaths among older patients with acute myocardial infarction and greater co-morbidity. Lower mortality was shown in patients undergoing diagnostic catheterisation and/or PTCA. After adjusting for age, diagnosis and co-morbidity, mortality affected women more than men in the overall population (OR 1.14, 95% CI: 1.06–1.22) and in the subgroup of patients where no procedure was performed (OR 1.16, 95% CI: 1.07–1.24). Gender was not an explanatory variable in the subgroups of patients who underwent some kind of procedure.

Conclusion

Gender has not been associated to in-hospital mortality in patients who undergo some kind of percutaneous cardiovascular procedure. However, in the group of patients without either diagnostic catheterisation or angioplasty, mortality was higher in women than in men.
Literature
1.
go back to reference Sonke G, Beaglehole R, Stewart A, Jackson R, Stewart F: Sex differences in case fatality before and after admission to hospital after acute cardiac events: analysis of community based coronary heart disease register. BMJ. 1996, 313: 853-55.CrossRef Sonke G, Beaglehole R, Stewart A, Jackson R, Stewart F: Sex differences in case fatality before and after admission to hospital after acute cardiac events: analysis of community based coronary heart disease register. BMJ. 1996, 313: 853-55.CrossRef
2.
go back to reference Hochman JS, McCabe CH, Stone PH, Becker RC, Cannon CP, DeFeo-Fraulini T, Thomson B, Steingart R, Knatterud G, Braunwald E: Outcome and profile of women and men presenting with acute coronary syndromes: a report from TIMI IIIB. J Am Coll Cardiol. 1997, 30: 141-8. 10.1016/S0735-1097(97)00107-1.CrossRef Hochman JS, McCabe CH, Stone PH, Becker RC, Cannon CP, DeFeo-Fraulini T, Thomson B, Steingart R, Knatterud G, Braunwald E: Outcome and profile of women and men presenting with acute coronary syndromes: a report from TIMI IIIB. J Am Coll Cardiol. 1997, 30: 141-8. 10.1016/S0735-1097(97)00107-1.CrossRef
3.
go back to reference Fox KAA, Poole-Wilson P, Clayton TC, Henderson RA, Shaw TRD, Wheatley DJ, Knight R, Pocock SJ: 5-year outcome of an interventional strategy in non-ST-elevation acute syndrome: the British Heart Foundation RITA 3 randomised trial. Lancet. 2005, 366: 914-20. 10.1016/S0140-6736(05)67222-4.CrossRef Fox KAA, Poole-Wilson P, Clayton TC, Henderson RA, Shaw TRD, Wheatley DJ, Knight R, Pocock SJ: 5-year outcome of an interventional strategy in non-ST-elevation acute syndrome: the British Heart Foundation RITA 3 randomised trial. Lancet. 2005, 366: 914-20. 10.1016/S0140-6736(05)67222-4.CrossRef
4.
go back to reference Vaccarino V, Rathore SS, Wenger NK, Frederick PD, Abramson JL, Barron HV, Manhapra A, Mallik S, Krumholz HM, National Registry of Myocardial Infarction Investigators: Sex and racial differences in the management of acute myocardial infarction, 1994 through 2002. N Engl J Med. 2005, 18: 671-82. 10.1056/NEJMsa032214.CrossRef Vaccarino V, Rathore SS, Wenger NK, Frederick PD, Abramson JL, Barron HV, Manhapra A, Mallik S, Krumholz HM, National Registry of Myocardial Infarction Investigators: Sex and racial differences in the management of acute myocardial infarction, 1994 through 2002. N Engl J Med. 2005, 18: 671-82. 10.1056/NEJMsa032214.CrossRef
5.
go back to reference Marrugat J, Sala J, Masia R, Pavesi M, Sanz G, Valle V, Molina L, Séres L, Elosua R: Mortality differences between men and women following first myocardial infarction. RESCATE Investigators. (Spanish acronym for Resources Used in Acute Coronary syndrome and Waiting Time). JAMA. 1998, 280: 1405-9. 10.1001/jama.280.16.1405.CrossRef Marrugat J, Sala J, Masia R, Pavesi M, Sanz G, Valle V, Molina L, Séres L, Elosua R: Mortality differences between men and women following first myocardial infarction. RESCATE Investigators. (Spanish acronym for Resources Used in Acute Coronary syndrome and Waiting Time). JAMA. 1998, 280: 1405-9. 10.1001/jama.280.16.1405.CrossRef
6.
go back to reference Berger JS, Brown DL: Impact of gender on mortality following primary angioplasty for acute myocardial infarction. Prog Cardiovasc Dis. 2004, 46: 297-304. 10.1016/j.pcad.2003.09.003.CrossRef Berger JS, Brown DL: Impact of gender on mortality following primary angioplasty for acute myocardial infarction. Prog Cardiovasc Dis. 2004, 46: 297-304. 10.1016/j.pcad.2003.09.003.CrossRef
7.
go back to reference Vaccarino V, Abramson JL, Veledar E, Weintraub WS: Sex differences in hospital mortality after coronary artery bypass surgery: evidence for a higher mortality in younger women. Circulation. 2002, 105: 1176-81. 10.1161/hc1002.105133.CrossRef Vaccarino V, Abramson JL, Veledar E, Weintraub WS: Sex differences in hospital mortality after coronary artery bypass surgery: evidence for a higher mortality in younger women. Circulation. 2002, 105: 1176-81. 10.1161/hc1002.105133.CrossRef
8.
go back to reference Wiviott S, Cannon CP, Morrow DA, Murphy SA, Gibson CM, McCabe CH, Sabatine MS, Rifai N, Giugliano RP, DiBattiste PM, Demopoulos LA, Antman EM, Braunwald E: Differential expression of cardiac biomarkers by gender in patients with unstable angina/non -ST- elevation myocardial infarction. A TACTICS-TIMI 18 (Treat Angina with Aggrastat and determine Cost of Therapy with an Invasive or Conservative Strategy -Trombolysis in Myocardial Infarction 18) Substudy. Circulation. 2004, 109: 580-6. 10.1161/01.CIR.0000109491.66226.26.CrossRef Wiviott S, Cannon CP, Morrow DA, Murphy SA, Gibson CM, McCabe CH, Sabatine MS, Rifai N, Giugliano RP, DiBattiste PM, Demopoulos LA, Antman EM, Braunwald E: Differential expression of cardiac biomarkers by gender in patients with unstable angina/non -ST- elevation myocardial infarction. A TACTICS-TIMI 18 (Treat Angina with Aggrastat and determine Cost of Therapy with an Invasive or Conservative Strategy -Trombolysis in Myocardial Infarction 18) Substudy. Circulation. 2004, 109: 580-6. 10.1161/01.CIR.0000109491.66226.26.CrossRef
9.
go back to reference O'Donnell S, Condell S, Begley C, Fitzgerald T: In-hospital care pathway delays: gender and myocardial infarction. J Adv Nurs. 2005, 52: 14-21. 10.1111/j.1365-2648.2005.03559.x.CrossRef O'Donnell S, Condell S, Begley C, Fitzgerald T: In-hospital care pathway delays: gender and myocardial infarction. J Adv Nurs. 2005, 52: 14-21. 10.1111/j.1365-2648.2005.03559.x.CrossRef
10.
go back to reference Janzon M, Levin LA, Shawhn E: Invasive treatment in unstable coronary artery disease promotes health-related quality of life: results from the FRISC II TRIAL. Am Heart J. 2004, 148: 114-20. 10.1016/j.ahj.2003.11.026.CrossRef Janzon M, Levin LA, Shawhn E: Invasive treatment in unstable coronary artery disease promotes health-related quality of life: results from the FRISC II TRIAL. Am Heart J. 2004, 148: 114-20. 10.1016/j.ahj.2003.11.026.CrossRef
11.
go back to reference Jenkins JS, Flaker GC, Nolte B, Price LA, Morris D, Kurz J, Petroski GF: Causes of higher in-hospital mortality in women than in men after acute myocardial infarction. Am J Cardiol. 1994, 73: 319-22. 10.1016/0002-9149(94)90001-9.CrossRef Jenkins JS, Flaker GC, Nolte B, Price LA, Morris D, Kurz J, Petroski GF: Causes of higher in-hospital mortality in women than in men after acute myocardial infarction. Am J Cardiol. 1994, 73: 319-22. 10.1016/0002-9149(94)90001-9.CrossRef
12.
go back to reference Aguado MJ, Márquez S: Differences between women's and men's access to interventional cardiovascular procedures at public hospitals in Andalusia (Spain). Rev Esp Cardiol. 2006, 59: 785-93. 10.1157/13091882.CrossRef Aguado MJ, Márquez S: Differences between women's and men's access to interventional cardiovascular procedures at public hospitals in Andalusia (Spain). Rev Esp Cardiol. 2006, 59: 785-93. 10.1157/13091882.CrossRef
13.
go back to reference Antoniucce D, Valenti R, Moschi G, Migliorini A, Trapani M, Santoro GM, Bolognose L, Dovellini EV: Sex-based differences in clinical and angiographic outcomes after primary angioplasty or stenting for acute myocardial infarction. Am J Cardiol. 2001, 87: 289-93. 10.1016/S0002-9149(00)01360-6.CrossRef Antoniucce D, Valenti R, Moschi G, Migliorini A, Trapani M, Santoro GM, Bolognose L, Dovellini EV: Sex-based differences in clinical and angiographic outcomes after primary angioplasty or stenting for acute myocardial infarction. Am J Cardiol. 2001, 87: 289-93. 10.1016/S0002-9149(00)01360-6.CrossRef
14.
go back to reference Ayanian JZ, Epstein AM: Differences in the use of procedures between women and men hospitalised for coronary heart disease. N Engl J Med. 1991, 325: 22115.CrossRef Ayanian JZ, Epstein AM: Differences in the use of procedures between women and men hospitalised for coronary heart disease. N Engl J Med. 1991, 325: 22115.CrossRef
15.
go back to reference Lansky AJ, Hochman JS, Ward PA, Mintz GS, Fabunmi R, Berger PB, New G, Grines CL, Pietras CG, Kern MJ, Ferrell M, Leon MB, Mehran R, White C, Mieres JH, Moses JW, Stone GW, Jakobs AK, American College of Cardiology Foundation, American Heart Association: Percutaneous coronary intervention and adjunctive pharmacotherapy in women: a statement for healthcare professionals from the American Heart Association. Circulation. 2005, 111: 940-53. 10.1161/01.CIR.0000155337.50423.C9.CrossRef Lansky AJ, Hochman JS, Ward PA, Mintz GS, Fabunmi R, Berger PB, New G, Grines CL, Pietras CG, Kern MJ, Ferrell M, Leon MB, Mehran R, White C, Mieres JH, Moses JW, Stone GW, Jakobs AK, American College of Cardiology Foundation, American Heart Association: Percutaneous coronary intervention and adjunctive pharmacotherapy in women: a statement for healthcare professionals from the American Heart Association. Circulation. 2005, 111: 940-53. 10.1161/01.CIR.0000155337.50423.C9.CrossRef
16.
go back to reference Charlson ME, Pompei P, Ales KL, MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987, 40: 373-83. 10.1016/0021-9681(87)90171-8.CrossRef Charlson ME, Pompei P, Ales KL, MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987, 40: 373-83. 10.1016/0021-9681(87)90171-8.CrossRef
17.
go back to reference Núñez JE, Núñez E, Fácila F, Bertomeu V, Llácer A, Bodí V, et al: Prognostic value of Charlson comorbidity index at 30 days and 1 year after acute myocardilal infarction. Rev Esp Cardiol. 2004, 57: 842-9. 10.1016/S1885-5857(06)60649-X.CrossRef Núñez JE, Núñez E, Fácila F, Bertomeu V, Llácer A, Bodí V, et al: Prognostic value of Charlson comorbidity index at 30 days and 1 year after acute myocardilal infarction. Rev Esp Cardiol. 2004, 57: 842-9. 10.1016/S1885-5857(06)60649-X.CrossRef
18.
go back to reference Agabiti N, Ancona C, Forastiere F, Arca M, Perucci CA: Evaluating outcomes of hospital care following coronary artery bypass surgery in Rome, Italy. Eur J Cardiothorac Surg. 2003, 23: 599-606. 10.1016/S1010-7940(02)00866-7.CrossRef Agabiti N, Ancona C, Forastiere F, Arca M, Perucci CA: Evaluating outcomes of hospital care following coronary artery bypass surgery in Rome, Italy. Eur J Cardiothorac Surg. 2003, 23: 599-606. 10.1016/S1010-7940(02)00866-7.CrossRef
19.
go back to reference Bodí V, Fácila F, Sanchís J, Llácer A, Ferrero JA, Chorro FJ: Gender differences in patients with suspected non-ST-segment elevation acute coronary syndromes. Implications for invasive management. Rev Esp Cardiol. 2003, 56: 412-6. 10.1157/13045659.CrossRef Bodí V, Fácila F, Sanchís J, Llácer A, Ferrero JA, Chorro FJ: Gender differences in patients with suspected non-ST-segment elevation acute coronary syndromes. Implications for invasive management. Rev Esp Cardiol. 2003, 56: 412-6. 10.1157/13045659.CrossRef
20.
go back to reference Vacek JL, Rosamond TL, Kramer PH, Crouse LJ, Porter CB, Robuck OW, White JL, Beauchamp GD: Sex-related differences in patients undergoing direct angioplasty for acute myocardial infarction. Am Heart J. 1993, 126: 521-5. 10.1016/0002-8703(93)90399-T.CrossRef Vacek JL, Rosamond TL, Kramer PH, Crouse LJ, Porter CB, Robuck OW, White JL, Beauchamp GD: Sex-related differences in patients undergoing direct angioplasty for acute myocardial infarction. Am Heart J. 1993, 126: 521-5. 10.1016/0002-8703(93)90399-T.CrossRef
21.
go back to reference Mehilli J, Kastrati A, Dirschinger J, Pache J, Seyfarth M, Blasini R, Hall D, Neumann FJ, Schömig A: Sex-based analysis of outcome in patients with acute myocardial infarction treated predominantly with percutaneous coronary intervention. JAMA. 2002, 287: 210-5. 10.1001/jama.287.2.210.CrossRef Mehilli J, Kastrati A, Dirschinger J, Pache J, Seyfarth M, Blasini R, Hall D, Neumann FJ, Schömig A: Sex-based analysis of outcome in patients with acute myocardial infarction treated predominantly with percutaneous coronary intervention. JAMA. 2002, 287: 210-5. 10.1001/jama.287.2.210.CrossRef
22.
go back to reference Sarria A, Palma M, García de Dueñas L: Manejo hospitalario de la Cardiopatía Isquémica en España. Análisis de Situación. Madrid: Agencia de Evaluación de Tecnología Sanitaria (AETS). Instituto de la Salud Carlos III. 2001 Sarria A, Palma M, García de Dueñas L: Manejo hospitalario de la Cardiopatía Isquémica en España. Análisis de Situación. Madrid: Agencia de Evaluación de Tecnología Sanitaria (AETS). Instituto de la Salud Carlos III. 2001
23.
go back to reference Glaser R, Herrmann HC, Murphy SA, Demopoulos LA, DiBattiste PM, Cannon CP, Braunwald E: Benefit of an early invasive management strategy in women with acute coronary syndromes. JAMA. 2002, 288: 3124-9. 10.1001/jama.288.24.3124.CrossRef Glaser R, Herrmann HC, Murphy SA, Demopoulos LA, DiBattiste PM, Cannon CP, Braunwald E: Benefit of an early invasive management strategy in women with acute coronary syndromes. JAMA. 2002, 288: 3124-9. 10.1001/jama.288.24.3124.CrossRef
24.
go back to reference Grines CL, Browne KF, Marco J, Rothbaum D, Stone GW, O'Keefe J, Everlie P, Donohue B, Chelliah N, Timmis GC: A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. The Primary Angioplasty in Myocardial Infarction Study Group. N Engl J Med. 1993, 328: 673-9. 10.1056/NEJM199303113281001.CrossRef Grines CL, Browne KF, Marco J, Rothbaum D, Stone GW, O'Keefe J, Everlie P, Donohue B, Chelliah N, Timmis GC: A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. The Primary Angioplasty in Myocardial Infarction Study Group. N Engl J Med. 1993, 328: 673-9. 10.1056/NEJM199303113281001.CrossRef
25.
go back to reference Hannan EL, Racz MJ, Arani DT, Ryan TJ, Walford G, McCallister BD: Short- and long-term mortality for patients undergoing primary angioplasty for acute myocardial infarction. J Am Coll Cardiol. 2000, 36: 1194-1201. 10.1016/S0735-1097(00)00866-4.CrossRef Hannan EL, Racz MJ, Arani DT, Ryan TJ, Walford G, McCallister BD: Short- and long-term mortality for patients undergoing primary angioplasty for acute myocardial infarction. J Am Coll Cardiol. 2000, 36: 1194-1201. 10.1016/S0735-1097(00)00866-4.CrossRef
26.
go back to reference Lansky AJ, Pietras C, Costa RA, Tsuchiya Y, Brodie BR, Cox DA: Gender differences in outcomes after primary angioplasty versus primary stenting with and without abciximab for acute myocardial infarction: results of the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) trial. Circulation. 2005, 111: 1611-8. 10.1161/01.CIR.0000160362.55803.40.CrossRef Lansky AJ, Pietras C, Costa RA, Tsuchiya Y, Brodie BR, Cox DA: Gender differences in outcomes after primary angioplasty versus primary stenting with and without abciximab for acute myocardial infarction: results of the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) trial. Circulation. 2005, 111: 1611-8. 10.1161/01.CIR.0000160362.55803.40.CrossRef
27.
go back to reference Presbitero P, Carcagnì A: Gender differences in the outcome of interventional cardiac procedures. Ital Heart J. 2003, 4: 522-7.PubMed Presbitero P, Carcagnì A: Gender differences in the outcome of interventional cardiac procedures. Ital Heart J. 2003, 4: 522-7.PubMed
28.
go back to reference Jacobs AK, Johnston JM, Haviland A, Brooks MM, Kelsey SF, Holmes DR: Improved outcomes for women undergoing contemporary percutaneous coronary intervention. J Am Coll Cardiol. 2002, 39: 1608-14. 10.1016/S0735-1097(02)01835-1.CrossRef Jacobs AK, Johnston JM, Haviland A, Brooks MM, Kelsey SF, Holmes DR: Improved outcomes for women undergoing contemporary percutaneous coronary intervention. J Am Coll Cardiol. 2002, 39: 1608-14. 10.1016/S0735-1097(02)01835-1.CrossRef
29.
go back to reference Swahn E: The care of patients with ischaemic heart disease from a gender perspective. Eur Heart J. 1998, 19: 1758-65. 10.1053/euhj.1998.1205.CrossRef Swahn E: The care of patients with ischaemic heart disease from a gender perspective. Eur Heart J. 1998, 19: 1758-65. 10.1053/euhj.1998.1205.CrossRef
30.
go back to reference Peterson ED, Lansky AJ, Kramer J, Anstrom K, Lanzilotta MJ: Effect of gender on the outcomes of contemporary percutaneous coronary intervention. Am J Cardiol. 2001, 88: 359-64. 10.1016/S0002-9149(01)01679-4.CrossRef Peterson ED, Lansky AJ, Kramer J, Anstrom K, Lanzilotta MJ: Effect of gender on the outcomes of contemporary percutaneous coronary intervention. Am J Cardiol. 2001, 88: 359-64. 10.1016/S0002-9149(01)01679-4.CrossRef
31.
go back to reference Saleem MA, Kannam H, Aronow WS, Weiss MB, Kalapatapu K, Pucillo AL: The effects of off-normal hours, age, and gender for coronary angioplasty on hospital mortality in patients undergoing coronary angioplasty for acute myocardial infarction. Am J Cardiol. 2004, 93: 763-4. 10.1016/j.amjcard.2003.11.057.CrossRef Saleem MA, Kannam H, Aronow WS, Weiss MB, Kalapatapu K, Pucillo AL: The effects of off-normal hours, age, and gender for coronary angioplasty on hospital mortality in patients undergoing coronary angioplasty for acute myocardial infarction. Am J Cardiol. 2004, 93: 763-4. 10.1016/j.amjcard.2003.11.057.CrossRef
32.
go back to reference Huxley R, Barzi F, Woodward M: Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ. 2006, 332: 73-8. 10.1136/bmj.38678.389583.7C.CrossRef Huxley R, Barzi F, Woodward M: Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ. 2006, 332: 73-8. 10.1136/bmj.38678.389583.7C.CrossRef
33.
go back to reference Gan AC, Beaver SK, HoucK PM, MacLehose RF, Lawson HL, Chan L: Treatment of acute myocardial infarction and 30-day mortality among women and men. N Engl J Med. 2000, 343: 8-15. 10.1056/NEJM200007063430102.CrossRef Gan AC, Beaver SK, HoucK PM, MacLehose RF, Lawson HL, Chan L: Treatment of acute myocardial infarction and 30-day mortality among women and men. N Engl J Med. 2000, 343: 8-15. 10.1056/NEJM200007063430102.CrossRef
Metadata
Title
Hospital mortality in acute coronary syndrome: differences related to gender and use of percutaneous coronary procedures
Authors
María J Aguado-Romeo
Soledad Márquez-Calderón
María L Buzón-Barrera
the Medical Practice Variations Andalusian Group
Publication date
01-12-2007
Publisher
BioMed Central
Published in
BMC Health Services Research / Issue 1/2007
Electronic ISSN: 1472-6963
DOI
https://doi.org/10.1186/1472-6963-7-110

Other articles of this Issue 1/2007

BMC Health Services Research 1/2007 Go to the issue