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Archives of Gynecology and Obstetrics

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01-03-2012 | General Gynecology

Hormone replacement therapy: relation to homocysteine and prooxidant-antioxidant status in healthy postmenopausal women

Authors: Cahide Gökkuşu, Zeynep Özbek, Gülten Tata

Published in: Archives of Gynecology and Obstetrics | Issue 3/2012

Abstract

Objectives

Studies have consistently shown a lower cardiovascular risk in women who received postmenopausal hormone replacement therapy (HRT).

Design and Methods

In this study, the effects of HRT were investigated on plasma total homocysteine (tHcy) and the oxidant-antioxidant status in postmenopausal women. 35 of postmenopausal receiving (2 mg estrodiol valerate + 1 mg cyproterone acetate) HRT group, the remaining 25 received orally placebo (NHRT group).

Results

There was no significant change in plasma tHcy levels between HRT and NHRT groups. Malondialdehyde (MDA) and total thiol (t-SH) correlated significantly with tHcy (0.388 and 0.478, respectively) content, and there was a significant negative correlation between E2 level and glutathione transferase (GST) activity (−0.425) in HRT group. Superoxide dismutase (SOD) and HDL-C correlated significantly with t-SH level (0.339 and 0.336, respectively) in plasma after HRT.

Conclusion

Our results show that HRT is beneficial in the protection against oxidative damage, and prevents atherosclerotic complications.

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Title: Hormone replacement therapy: relation to homocysteine and prooxidant-antioxidant status in healthy postmenopausal women
Authors: Cahide Gökkuşu
Zeynep Özbek
Gülten Tata
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 3/2012
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-011-2051-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Hormone replacement therapy: relation to homocysteine and prooxidant-antioxidant status in healthy postmenopausal women

Abstract

Objectives

Design and Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Design and Methods

Results

Conclusion

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