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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2001

Open Access 01-12-2001 | Research article

Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials

Authors: David J Torgerson, Sally EM Bell-Syer

Published in: BMC Musculoskeletal Disorders | Issue 1/2001

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Abstract

Background

Hormone replacement therapy (HRT) is often seen as the treatment of choice for preventing fractures in women. We undertook a recent meta-analysis of randomised trials which suggested that HRT reduced non-vertebral fractures by 30%. In this analysis we extend that analysis to vertebral fractures.

Methods

We searched the main electronic databases until the end of August 2001. We sought all randomised controlled trials (RCTs) of HRT where women had been randomised to at least 12 months of HRT or to no HRT.

Results

We found 13 RCTs. Overall there was a 33% reduction in vertebral factures (95% confidence interval (CI) 45% to 98%).

Conclusions

This review and meta-analysis showed a significant reduction in vertebral fractures associated with HRT use.
Appendix
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Metadata
Title
Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials
Authors
David J Torgerson
Sally EM Bell-Syer
Publication date
01-12-2001
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2001
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/1471-2474-2-7

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