Skip to main content
Top
Published in: Systematic Reviews 1/2018

Open Access 01-12-2018 | Protocol

HIV-related data among key populations to inform evidence-based responses: protocol of a systematic review

Authors: Amrita Rao, Sheree Schwartz, Keith Sabin, Tisha Wheeler, Jinkou Zhao, James Hargreaves, Stefan Baral, on behalf of the Global.HIV Research Group

Published in: Systematic Reviews | Issue 1/2018

Login to get access

Abstract

Background

Key populations who bear a disproportionate burden of HIV, including female sex workers, men who have sex with men, people who use drugs, transgender people, and incarcerated populations, have been understudied, especially in the context of broadly generalized HIV epidemics. Program and investment planning documents often do not take into account the data that do exist. Prior systematic reviews have been comprehensive, but lack sustainability and relevance over time. This review aims to synthesize all available data for key populations and present the data through an accessible, updatable user-friendly graphic interface. The outputs of this systematic review will serve as a resource for decision-makers, providing government stakeholders and donors with the tools to make evidence-based decisions for national planning.

Methods

We will conduct a systematic review of data published or made available between January 1, 2006, and January 1, 2019, that captures the burden of HIV, both prevalence and incidence estimates, HIV prevention and treatment cascades, key population size estimates, experienced violence, consistent condom use, and engagement with healthcare systems for female sex workers, men who have sex with men, people who use drugs, transgender people, and incarcerated populations. A team of reviewers will use Covidence to conduct two independent reviews of both title/abstract and full text for each article. REDCap will be used for data abstraction and storage.

Discussion

Findings from this systematic review and the development of the enhanced graphical interface to display data, along with ongoing efforts to build capacity among key stakeholders to better use and interpret available data, will help ensure that available epidemiologic data related to key populations can be appropriately used to guide large-scale HIV funding and programmatic responses.

Systematic review registration

PROPSERO CRD42016047259.
Appendix
Available only for authorised users
Literature
3.
go back to reference UNAIDS. The gap report. Geneva, Switzerland; 2014. UNAIDS. The gap report. Geneva, Switzerland; 2014.
4.
go back to reference Kim HY, Grosso A, Ky-Zerbo O, Lougue M, Stahlman S, Samadoulougou C, et al. Stigma as a barrier to health care utilization among female sex workers and men who have sex with men in Burkina Faso. Ann Epidemiol. 2018;28(1):13–9.CrossRefPubMed Kim HY, Grosso A, Ky-Zerbo O, Lougue M, Stahlman S, Samadoulougou C, et al. Stigma as a barrier to health care utilization among female sex workers and men who have sex with men in Burkina Faso. Ann Epidemiol. 2018;28(1):13–9.CrossRefPubMed
5.
go back to reference Baral S, Beyrer C, Muessig K, Poteat T, Wirtz AL, Decker MR, et al. Burden of HIV among female sex workers in low-income and middle-income countries: a systematic review and meta-analysis. Lancet Infect Dis. 2012;12(7):538–49.CrossRefPubMed Baral S, Beyrer C, Muessig K, Poteat T, Wirtz AL, Decker MR, et al. Burden of HIV among female sex workers in low-income and middle-income countries: a systematic review and meta-analysis. Lancet Infect Dis. 2012;12(7):538–49.CrossRefPubMed
6.
go back to reference Fitzgerald-Husek A, Van Wert MJ, Ewing WF, Grosso AL, Holland CE, Katterl R, et al. Measuring stigma affecting sex workers (SW) and men who have sex with men (MSM): a systematic review. PLoS One. 2017;12(11):e0188393.CrossRefPubMedPubMedCentral Fitzgerald-Husek A, Van Wert MJ, Ewing WF, Grosso AL, Holland CE, Katterl R, et al. Measuring stigma affecting sex workers (SW) and men who have sex with men (MSM): a systematic review. PLoS One. 2017;12(11):e0188393.CrossRefPubMedPubMedCentral
7.
go back to reference Stangl AL, Lloyd JK, Brady LM, Holland CE, Baral S. A systematic review of interventions to reduce HIV-related stigma and discrimination from 2002 to 2013: how far have we come? J Int AIDS Soc. 2013;16(3 Suppl 2):18734.CrossRefPubMedPubMedCentral Stangl AL, Lloyd JK, Brady LM, Holland CE, Baral S. A systematic review of interventions to reduce HIV-related stigma and discrimination from 2002 to 2013: how far have we come? J Int AIDS Soc. 2013;16(3 Suppl 2):18734.CrossRefPubMedPubMedCentral
8.
go back to reference Pettifor A, Rosenberg N, Behets F. The need to focus on sex workers in generalized HIV epidemic settings. Sex Transm Dis. 2011;38(4):324–5.PubMedPubMedCentral Pettifor A, Rosenberg N, Behets F. The need to focus on sex workers in generalized HIV epidemic settings. Sex Transm Dis. 2011;38(4):324–5.PubMedPubMedCentral
9.
go back to reference Mishra S, Boily MC, Schwartz S, Beyrer C, Blanchard JF, Moses S, et al. Data and methods to characterize the role of sex work and to inform sex work programs in generalized HIV epidemics: evidence to challenge assumptions. Ann Epidemiol. 2016;26(8):557–69.CrossRefPubMedPubMedCentral Mishra S, Boily MC, Schwartz S, Beyrer C, Blanchard JF, Moses S, et al. Data and methods to characterize the role of sex work and to inform sex work programs in generalized HIV epidemics: evidence to challenge assumptions. Ann Epidemiol. 2016;26(8):557–69.CrossRefPubMedPubMedCentral
10.
go back to reference Boily MC, Pickles M, Alary M, Baral S, Blanchard J, Moses S, et al. What really is a concentrated HIV epidemic and what does it mean for West and Central Africa? Insights from mathematical modeling. J Acquir Immune Defic Syndr. 2015;68(Suppl 2):S74–82.CrossRefPubMed Boily MC, Pickles M, Alary M, Baral S, Blanchard J, Moses S, et al. What really is a concentrated HIV epidemic and what does it mean for West and Central Africa? Insights from mathematical modeling. J Acquir Immune Defic Syndr. 2015;68(Suppl 2):S74–82.CrossRefPubMed
11.
go back to reference Mishra S, Pickles M, Blanchard JF, Moses S, Shubber Z, Boily MC. Validation of the modes of transmission model as a tool to prioritize HIV prevention targets: a comparative modelling analysis. PLoS One. 2014;9(7):e101690.CrossRefPubMedPubMedCentral Mishra S, Pickles M, Blanchard JF, Moses S, Shubber Z, Boily MC. Validation of the modes of transmission model as a tool to prioritize HIV prevention targets: a comparative modelling analysis. PLoS One. 2014;9(7):e101690.CrossRefPubMedPubMedCentral
12.
go back to reference Mishra S, Pickles M, Blanchard JF, Moses S, Boily MC. Distinguishing sources of HIV transmission from the distribution of newly acquired HIV infections: why is it important for HIV prevention planning? Sex Transm Infect. 2014;90(1):19–25.CrossRefPubMed Mishra S, Pickles M, Blanchard JF, Moses S, Boily MC. Distinguishing sources of HIV transmission from the distribution of newly acquired HIV infections: why is it important for HIV prevention planning? Sex Transm Infect. 2014;90(1):19–25.CrossRefPubMed
13.
go back to reference Mishra S, Steen R, Gerbase A, Lo YR, Boily MC. Impact of high-risk sex and focused interventions in heterosexual HIV epidemics: a systematic review of mathematical models. PLoS One. 2012;7(11):e50691.CrossRefPubMedPubMedCentral Mishra S, Steen R, Gerbase A, Lo YR, Boily MC. Impact of high-risk sex and focused interventions in heterosexual HIV epidemics: a systematic review of mathematical models. PLoS One. 2012;7(11):e50691.CrossRefPubMedPubMedCentral
14.
go back to reference Baral SD, Lyons C, Sullivan E, Kurani S, Sherwood J, Millett G, et al. The uptake of population size estimation studies for key populations in guiding HIV responses across sub-Saharan Africa: a systematic review. Durban, South Africa: AIDS 2016; 2016. Baral SD, Lyons C, Sullivan E, Kurani S, Sherwood J, Millett G, et al. The uptake of population size estimation studies for key populations in guiding HIV responses across sub-Saharan Africa: a systematic review. Durban, South Africa: AIDS 2016; 2016.
15.
go back to reference Belay T, Mbuya N, Rajan V. Data utilization and evidence-based decision making the health sector: survey of three Indian States. South Asia human development sector series: World Bank; 2009. p. 27. Belay T, Mbuya N, Rajan V. Data utilization and evidence-based decision making the health sector: survey of three Indian States. South Asia human development sector series: World Bank; 2009. p. 27.
16.
go back to reference Moher D, Liberati A, Tetzlaff J, Altman DG, Group TP. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med. 2009;6(7):e1000097.CrossRefPubMedPubMedCentral Moher D, Liberati A, Tetzlaff J, Altman DG, Group TP. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med. 2009;6(7):e1000097.CrossRefPubMedPubMedCentral
17.
go back to reference Sabin K, Zhao J, Garcia Calleja JM, Sheng Y, Arias Garcia S, Reinisch A, et al. Availability and quality of size estimations of female sex workers, men who have sex with men, people who inject drugs and transgender women in low- and middle-income countries. PLoS One. 2016;11(5):e0155150.CrossRefPubMedPubMedCentral Sabin K, Zhao J, Garcia Calleja JM, Sheng Y, Arias Garcia S, Reinisch A, et al. Availability and quality of size estimations of female sex workers, men who have sex with men, people who inject drugs and transgender women in low- and middle-income countries. PLoS One. 2016;11(5):e0155150.CrossRefPubMedPubMedCentral
18.
go back to reference DeBeck K, Cheng T, Montaner JS, Beyrer C, Elliott R, Sherman S, et al. HIV and the criminalisation of drug use among people who inject drugs: a systematic review. Lancet HIV. 2017;4(8):e357–e74.CrossRefPubMedPubMedCentral DeBeck K, Cheng T, Montaner JS, Beyrer C, Elliott R, Sherman S, et al. HIV and the criminalisation of drug use among people who inject drugs: a systematic review. Lancet HIV. 2017;4(8):e357–e74.CrossRefPubMedPubMedCentral
19.
go back to reference Baral SD, Poteat T, Stromdahl S, Wirtz AL, Guadamuz TE, Beyrer C. Worldwide burden of HIV in transgender women: a systematic review and meta-analysis. Lancet Infect Dis. 2013;13(3):214–22.CrossRefPubMed Baral SD, Poteat T, Stromdahl S, Wirtz AL, Guadamuz TE, Beyrer C. Worldwide burden of HIV in transgender women: a systematic review and meta-analysis. Lancet Infect Dis. 2013;13(3):214–22.CrossRefPubMed
20.
go back to reference Beyrer C, Baral SD, van Griensven F, Goodreau SM, Chariyalertsak S, Wirtz AL, et al. Global epidemiology of HIV infection in men who have sex with men. Lancet. 2012;380(9839):367–77.CrossRefPubMedPubMedCentral Beyrer C, Baral SD, van Griensven F, Goodreau SM, Chariyalertsak S, Wirtz AL, et al. Global epidemiology of HIV infection in men who have sex with men. Lancet. 2012;380(9839):367–77.CrossRefPubMedPubMedCentral
21.
go back to reference Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies [Internet]. National Heart. In: Lung and blood institute; 2017. Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies [Internet]. National Heart. In: Lung and blood institute; 2017.
22.
go back to reference Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 1998;52:377–84.CrossRefPubMedPubMedCentral Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 1998;52:377–84.CrossRefPubMedPubMedCentral
23.
go back to reference Boily MC, Pickles M, Lowndes CM, Ramesh BM, Washington R, Moses S, et al. Positive impact of a large-scale HIV prevention programme among female sex workers and clients in South India. AIDS. 2013;27(9):1449–60.CrossRefPubMed Boily MC, Pickles M, Lowndes CM, Ramesh BM, Washington R, Moses S, et al. Positive impact of a large-scale HIV prevention programme among female sex workers and clients in South India. AIDS. 2013;27(9):1449–60.CrossRefPubMed
24.
go back to reference Freeman EE, Orroth KK, White RG, Glynn JR, Bakker R, Boily MC, et al. Proportion of new HIV infections attributable to herpes simplex 2 increases over time: simulations of the changing role of sexually transmitted infections in sub-Saharan African HIV epidemics. Sex Transm Infect. 2007;83(Suppl 1):i17–24.CrossRefPubMed Freeman EE, Orroth KK, White RG, Glynn JR, Bakker R, Boily MC, et al. Proportion of new HIV infections attributable to herpes simplex 2 increases over time: simulations of the changing role of sexually transmitted infections in sub-Saharan African HIV epidemics. Sex Transm Infect. 2007;83(Suppl 1):i17–24.CrossRefPubMed
25.
go back to reference Baral S, Sifakis F, Cleghorn F, Beyrer C. Elevated risk for HIV infection among men who have sex with men in low- and middle-income countries 2000-2006: a systematic review. PLoS Med. 2007;4(12):e339.CrossRefPubMedPubMedCentral Baral S, Sifakis F, Cleghorn F, Beyrer C. Elevated risk for HIV infection among men who have sex with men in low- and middle-income countries 2000-2006: a systematic review. PLoS Med. 2007;4(12):e339.CrossRefPubMedPubMedCentral
26.
go back to reference MacCarthy S, Poteat T, Xia Z, Roque NL, Hyun Jin Kim A, Baral S, et al. Current research gaps: a global systematic review of HIV and sexually transmissible infections among transgender populations. Sex Health. 2017;14(5):456–68.CrossRefPubMedPubMedCentral MacCarthy S, Poteat T, Xia Z, Roque NL, Hyun Jin Kim A, Baral S, et al. Current research gaps: a global systematic review of HIV and sexually transmissible infections among transgender populations. Sex Health. 2017;14(5):456–68.CrossRefPubMedPubMedCentral
27.
go back to reference Papworth E, Ceesay N, An L, Thiam-Niangoin M, Ky-Zerbo O, Holland C, et al. Epidemiology of HIV among female sex workers, their clients, men who have sex with men and people who inject drugs in West and Central Africa. J Int AIDS Soc. 2013;16(Suppl 3):18751.CrossRefPubMedPubMedCentral Papworth E, Ceesay N, An L, Thiam-Niangoin M, Ky-Zerbo O, Holland C, et al. Epidemiology of HIV among female sex workers, their clients, men who have sex with men and people who inject drugs in West and Central Africa. J Int AIDS Soc. 2013;16(Suppl 3):18751.CrossRefPubMedPubMedCentral
28.
go back to reference Poteat T, Scheim A, Xavier J, Reisner S, Baral S. Global epidemiology of HIV infection and related syndemics affecting transgender people. J Acquir Immune Defic Syndr. 2016;72(Suppl 3):S210–9.CrossRefPubMedPubMedCentral Poteat T, Scheim A, Xavier J, Reisner S, Baral S. Global epidemiology of HIV infection and related syndemics affecting transgender people. J Acquir Immune Defic Syndr. 2016;72(Suppl 3):S210–9.CrossRefPubMedPubMedCentral
29.
go back to reference Stromdahl S, Hickson F, Pharris A, Sabido M, Baral S, Thorson A. A systematic review of evidence to inform HIV prevention interventions among men who have sex with men in Europe. Euro Surveill. 2015;20(15):21096.CrossRefPubMed Stromdahl S, Hickson F, Pharris A, Sabido M, Baral S, Thorson A. A systematic review of evidence to inform HIV prevention interventions among men who have sex with men in Europe. Euro Surveill. 2015;20(15):21096.CrossRefPubMed
30.
go back to reference Sullivan PS, Jones JS, Baral SD. The global north: HIV epidemiology in high-income countries. Curr Opin HIV AIDS. 2014;9(2):199–205.CrossRefPubMed Sullivan PS, Jones JS, Baral SD. The global north: HIV epidemiology in high-income countries. Curr Opin HIV AIDS. 2014;9(2):199–205.CrossRefPubMed
31.
go back to reference Schwartz SR, Nowak RG, Orazulike I, Keshinro B, Ake J, Kennedy S, et al. The immediate eff ect of the same-sex marriage prohibition act on stigma, discrimination, and engagement on HIV prevention and treatment services in men who have sex with men in Nigeria: analysis of prospective data from the TRUST cohort. Lancet HIV. 2015;2(7):e299–306.CrossRefPubMedPubMedCentral Schwartz SR, Nowak RG, Orazulike I, Keshinro B, Ake J, Kennedy S, et al. The immediate eff ect of the same-sex marriage prohibition act on stigma, discrimination, and engagement on HIV prevention and treatment services in men who have sex with men in Nigeria: analysis of prospective data from the TRUST cohort. Lancet HIV. 2015;2(7):e299–306.CrossRefPubMedPubMedCentral
Metadata
Title
HIV-related data among key populations to inform evidence-based responses: protocol of a systematic review
Authors
Amrita Rao
Sheree Schwartz
Keith Sabin
Tisha Wheeler
Jinkou Zhao
James Hargreaves
Stefan Baral
on behalf of the Global.HIV Research Group
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Systematic Reviews / Issue 1/2018
Electronic ISSN: 2046-4053
DOI
https://doi.org/10.1186/s13643-018-0894-3

Other articles of this Issue 1/2018

Systematic Reviews 1/2018 Go to the issue