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01-10-2019 | Original Article

Histopathological and biochemical effects of aqueous extract of Tragopogon graminifolius on the liver tissues of Wistar rats fed with high-fat diet

Authors: Mohammad Mahdi Zangeneh, Saman Salmani, Akram Zangeneh, Reza Khedri, Mohammad Saeid Zarei

Published in: Comparative Clinical Pathology | Issue 5/2019

Abstract

The fatty liver disease is one of the most usual metabolic diseases among people around the world. Appropriate strategies for treating this disease are prioritized by each country. The purpose of the new research was to survey the therapeutical property of aqueous extract of Tragopogon graminifolius on the high-fat diet-induced fatty liver disease in Wistar male rats. In this study, 60 rats were used. A total of ten rats were chosen as the negative control, and the rest of them were treated with a high-fat diet for 4 months. Then, the animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, and four groups receiving the aqueous extract of T. graminifolius at 20, 40, 80, and 160 mg/kg concentrations. After 2 months, the rats were sacrificed, and the blood and liver samples of them were collected for biochemical and histopathological parameter analysis. All doses of T. graminifolius could significantly (p ≤ 0.05) decrease the raised levels of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, and glucose and increased HDL, total protein, albumin, SOD, and CAT as compared to the untreated group. Also, aqueous extract of T. graminifolius decreased the degree of hepatic steatosis as compared to the untreated group. In conclusion, the obtained results demonstrated the hepatoprotective effect of T. graminifolius aqueous extract.

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Title: Histopathological and biochemical effects of aqueous extract of Tragopogon graminifolius on the liver tissues of Wistar rats fed with high-fat diet
Authors: Mohammad Mahdi Zangeneh
Saman Salmani
Akram Zangeneh
Reza Khedri
Mohammad Saeid Zarei
Publication date: 01-10-2019
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 5/2019
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-018-2828-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Histopathological and biochemical effects of aqueous extract of Tragopogon graminifolius on the liver tissues of Wistar rats fed with high-fat diet

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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