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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2013

Open Access 01-12-2013 | Research

Histological subtypes and characteristic structures of HPV-associated oropharyngeal carcinoma; study with Japanese cases

Authors: Mitsuhisa Fujimaki, Yuki Fukumura, Keiko Mitani, Aiko Kurisaki, Junkichi Yokoyama, Katsuhisa Ikeda, Takashi Yao

Published in: Diagnostic Pathology | Issue 1/2013

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Abstract

Background

Human papillomavirus-associated oropharyngeal carcinoma (HPV-OPC) is clinicopathologically distinct entity from the HPV-unassociated one (nHPV-OPC). This study aimed to determine the relationship between histological subtypes of OPC and HPV status for Japanese cases and to identify histological structures of HPV-OPC.

Methods

66 OPC cases were categorized into conventional squamous cell carcinoma (SCC) and the variants. Conventional SCC was subcategorized into keratinizing (KSCC), non-keratinizing (NKSCC), and hybrid SCC (HSCC). HPV status of all cases was determined using p16-immunohistochemistry and HPV-DNA ISH.

Results

Two histological subtypes, NKSCC and HSCC, tended to be HPV-OPC and KSCC tended to be nHPV-OPC with statistical significance. Two histological structures, abrupt keratinization, defined in the text, and comedo-necrosis among non-maturing tumor island, were observed for 58.1% and 38.7% of HPV-OPC, and tended to exist for HPV-OPC with statistical significance.

Conclusions

This study showed the association of NKSCC/HSCC with HPV-OPC in Japanese cases, and two histological structures, abrupt keratinization and comedo-necrosis among non-maturing island, were considered characteristic histological features of HPV-OPC.

Virtual slides

The virtual slide(s) for this article can be found here:http://​www.​diagnosticpathol​ogy.​diagnomx.​eu/​vs/​1816432541113073​.
Appendix
Available only for authorised users
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Metadata
Title
Histological subtypes and characteristic structures of HPV-associated oropharyngeal carcinoma; study with Japanese cases
Authors
Mitsuhisa Fujimaki
Yuki Fukumura
Keiko Mitani
Aiko Kurisaki
Junkichi Yokoyama
Katsuhisa Ikeda
Takashi Yao
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2013
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-8-211

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