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Virchows Archiv
Published in: Virchows Archiv 6/2006

01-12-2006 | Original Article

Histological risk markers for non-cardia early gastric cancer

Pattern of mucin expression and gastric cancer

Authors: Akiko Shiotani, Ken Haruma, Noriya Uedo, Hiroyasu Iishi, Ryu Ishihara, Masaharu Tatsuta, Mitutaka Kumamoto, Yukinori Nakae, Shingo Ishiguro, David Y. Graham

Published in: Virchows Archiv | Issue 6/2006

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Abstract

There are limited data regarding the prognostic value of the pattern of mucin expression in IM. To examine the role of the type of IM and pattern of mucin expression in IM as histological risk markers of gastric cancer, 80 patients with a history of endoscopic mucosal resection (EMR) for early gastric cancer and 80 sex and age-matched controls were studied. Serum levels of pepsinogen (PG) were measured by RIA, and MUC2, MUC5AC and MUC6 were evaluated immunohistochemically. There is a significant association between types of IM and atrophic scores or PG levels. The most incomplete IM (type II and III) preserving gastric mucin is the gastric and intestinal mixed (GI) type, whereas the complete type is the intestinal (I) type especially in the corpus lesser curve. Gastric cancer was most significantly associated with incomplete IM in the corpus lesser curve (OR=6.4; 95% CI, 2.0–21, p=0.002). Asynchronous multiple lesions were associated with incomplete IM in the corpus greater curve (OR=4.8; 95% CI, 1.4–16, p=0.01). Classification of IM obtained using fixed-point biopsy samples may enhance the ability of surveillance programs to detect patients at increased risk of gastric cancer.
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Metadata
Title
Histological risk markers for non-cardia early gastric cancer
Pattern of mucin expression and gastric cancer
Authors
Akiko Shiotani
Ken Haruma
Noriya Uedo
Hiroyasu Iishi
Ryu Ishihara
Masaharu Tatsuta
Mitutaka Kumamoto
Yukinori Nakae
Shingo Ishiguro
David Y. Graham
Publication date
01-12-2006
Publisher
Springer-Verlag
Published in
Virchows Archiv / Issue 6/2006
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-006-0300-8

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