Histological heterogeneity between primary and metastatic cancer in a pathologic confirmed case of isolated optic disc metastasis of prostate adenocarcinoma

Excerpt

Metastatic choroidal cancer was first described by Pearls [1]. Since then, many studies have reported intraocular metastasis in the uveal tract, optic nerve, and optic disc [2‐5]. However, solitary optic disc metastasis from prostate cancer is extremely rare. To the best of our knowledge, only three cases of optic disc involvement from prostate cancer have been reported previously [3‐5] Nevertheless, the clinical features of these three cases are similar to the features of optic nerve infiltration, and include optic disc edema and optic nerve thickening, rather than the features of solitary mass-like lesions. Furthermore, physicians tend to diagnose the optic disc mass clinically without pathologic confirmation [2]. A vitrectomy-based biopsy has only been conducted by Fukuda et al. to treat metastatic pulmonary carcinoma in the optic disc [6]. In addition, as far as the authors know, the histological and immunohistochemical consistencies between primary and secondary tumors have never been studied in intraocular metastasis. …