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01-05-2009 | Case Report

Histiocytic/dendritic cell sarcoma arising from follicular lymphoma involving the bone: a case report and review of literature

Authors: Da Zhang, Joseph McGuirk, Siddhartha Ganguly, Diane L. Persons

Published in: International Journal of Hematology | Issue 4/2009

Abstract

Histiocytic/dendritic cell sarcomas arising from follicular lymphoma are very rare and poorly understood lesions. We describe a case, which is unique in that it presented with a hipbone lesion simultaneously with axillary lymphadenopathy. Biopsy of the axillary lymph node showed a low-grade follicular lymphoma. The hipbone lesion was comprised two cell populations, one representing diffuse large B cell lymphoma and the other a histiocytic/dendritic sarcoma. The cells of all three lesions contained an IGH/BCL2 rearrangement, suggesting that both diffuse large B cell lymphoma and histiocytic/dendritic sarcoma differentiation developed from the same low grade precursor (follicular lymphoma). This case illustrates that sarcomatous transdifferentiation of follicular lymphoma can be an unpredictable local phenomenon and that it can occur extra nodally in the bone marrow. It may also occur concurrently with the progression of follicular lymphoma to a diffuse large B cell lymphoma.

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al. WHO classification of tumour of haematopoietic and lymphoid tissue. 4th ed. Lyon: International Agency for Research on Cancer (IARC); 2008.

Haarer CF, Roberts RA, Gromas TM, Rimsza LM. Immunohistochemical classification of De Novo, transformed and relapsed diffuse large B-cell lymphoma into germinal center B cell and non germinal center B-cell subtypes correlates with gene expression profile and patient survival. Arch Pathol Lab Med. 2006;130:1819–24.PubMed

Christie L, Kermohan N, Levison D, et al. cMYC translocation in t(14;18) positive follicular lymphoma at presentation: an adverse prognostic indicator? Leuk Lymphoma. 2008;49:470–6. doi:10.1080/10428190701836845.CrossRefPubMed

Vasef MA, Zaatari GS, Chan WC, Sun NC, Weiss LM, Brynes RK. Dendritic cell tumors associated with low-grade B-cell malignancies: report of three cases. Am J Clin Pathol. 1995;104:696–701.CrossRefPubMed

Cossu A, Deiana A, Lissia A, et al. Synchronous interdigitating dendritic cell sarcoma and B-cell small lymphocytic lymphoma in a lymph node. Arch Pathol Lab Med. 2006;130:544–7.PubMed

Gaertner EM, Tsokos M, Derringer GA, Neuhauser TS, Arciero C, Andriko JA. Interdigitating dendritic cell sarcoma: a report of four cases and review of the literature. Am J Clin Pathol. 2001;115:589–97. doi:10.1309/M95G-7DQ2-TLQL-7Q11.CrossRefPubMed

Wetzler M, Kurzrock R, Goodacre AM, McLaughlin P, Ku S, Talpaz M. Transformation of chronic lymphocytic leukemia to lymphoma of true histiocytic type. Cancer. 1995;76:609–17. doi:10.1002/1097-0142(19950815)76:4<609::AID-CNCR2820760411>3.0.CO;2-Y.CrossRefPubMed

Alvaro T, Bosch R, Salvado MT, Piris MA. True histiocytic lymphoma of the stomach associated with low-grade B-cell mucosa-associated lymphoid tissue (MALT)-type lymphoma. Am J Surg Pathol. 1996;20:1406–11. doi:10.1097/00000478-199611000-00013.CrossRefPubMed

Feldman AL, Minniti C, Santi M, Downing JR, Raffeld M, Jaffe ES. Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal origin. Lancet Oncol. 2004;5:248–50. doi:10.1016/S1470-2045(04)01428-7.CrossRefPubMed

10.

Magni M, Di Nicola M, Carlo-Stella C, et al. Identical rearrangement of immunoglobulin heavy chain gene in neoplastic Langerhans cells and B-lymphocytes: evidence for a common precursor. Leuk Res. 2002;26:1131–3. doi:10.1016/S0145-2126(02)00009-7.CrossRefPubMed

11.

Feldman AL, Arber DA, Pittaluga S, et al. Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone. Blood. 2008;111:5433–8. doi:10.1182/blood-2007-11-124792.CrossRefPubMedPubMedCentral

Title: Histiocytic/dendritic cell sarcoma arising from follicular lymphoma involving the bone: a case report and review of literature
Authors: Da Zhang
Joseph McGuirk
Siddhartha Ganguly
Diane L. Persons
Publication date: 01-05-2009
Publisher: Springer Japan
Published in: International Journal of Hematology / Issue 4/2009
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI: https://doi.org/10.1007/s12185-009-0300-y

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