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Molecular Imaging and Biology
Published in: Molecular Imaging and Biology 3/2015

01-06-2015 | Research Article

Hippocampal Deep Brain Stimulation Reduces Glucose Utilization in the Healthy Rat Brain

Authors: Nathalie Van Den Berge, Vincent Keereman, Christian Vanhove, Bregt Van Nieuwenhuyse, Pieter van Mierlo, Robrecht Raedt, Kristl Vonck, Paul Boon, Roel Van Holen

Published in: Molecular Imaging and Biology | Issue 3/2015

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Abstract

Purpose

The effects of deep brain stimulation (DBS) have been studied primarily by cellular studies, which lack the ability to elucidate DBS-related responses on a whole-brain scale. 2-Deoxy-2-[18F]fluoro-d-glucose positron emission tomography ([18F]FDG-PET) reflects changes in neural activity throughout the entire brain volume. The aim of this study was to investigate the whole-brain effect of DBS on the glucose utilization in healthy rats.

Procedures

Seven rats were implanted with a DBS electrode in the right hippocampus and injected with [18F]FDG to measure the glucose metabolism during DBS.

Results

Analysis reveals significant DBS-induced decreases in the glucose metabolism in the bilateral hippocampus and other limbic structures.

Conclusions

This study demonstrates that DBS exhibits not only a local effect around the electrode tip but also in other limbic regions. [18F]FDG-PET studies have the potential to provide better insight into the mechanism of action of DBS by simultaneously observing activity at multiple sites in the brain.
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Metadata
Title
Hippocampal Deep Brain Stimulation Reduces Glucose Utilization in the Healthy Rat Brain
Authors
Nathalie Van Den Berge
Vincent Keereman
Christian Vanhove
Bregt Van Nieuwenhuyse
Pieter van Mierlo
Robrecht Raedt
Kristl Vonck
Paul Boon
Roel Van Holen
Publication date
01-06-2015
Publisher
Springer US
Published in
Molecular Imaging and Biology / Issue 3/2015
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-014-0801-9

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