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Forensic Science, Medicine and Pathology
Published in: Forensic Science, Medicine and Pathology 2/2016

01-06-2016 | Commentary

Hippocampal abnormalities and sudden childhood death

Author: Jeffrey Noebels

Published in: Forensic Science, Medicine and Pathology | Issue 2/2016

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Excerpt

Do postmortem structural changes in the hippocampal formation explain the still mysterious mechanism of premature mortality in otherwise normal children? Could clinically unrecognized seizures provide a missing link between two syndromes featuring sudden unexpected death in children, SUDC, and individuals with a history of epilepsy, SUDEP? …
Literature
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Hefti MM, Kinney HC, Cryan JB, Haas EA, Chadwick AE, Crandall LA, et al. Sudden unexpected death in early childhood: general observations in a series of 151 cases: part 1 of the investigations of the San Diego SUDC Research Project. Forensic Sci Med Pathol. 2016;12:4–13.CrossRefPubMedPubMedCentral
2.
Hefti MM, Cryan JB, Haas EA, Chadwick AE, Crandall LA, Trachtenberg FL, et al. Hippocampal malformation associated with sudden death in early childhood: a neuropathologic study: part 2 of the investigations of The San Diego SUDC Research Project. Forensic Sci Med Pathol. 2016;12:14–25.CrossRefPubMed
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Chan S, Bello JA, Shinnar S, Hesdorffer DC, Lewis DV, MacFall J, et al. Hippocampal malrotation is associated with prolonged febrile seizures: results of the FEBSTAT study. AJR. 2015;205:1068–74.CrossRefPubMed
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Goldman AM, Glasscock E, Yoo J, Chen TT, Klassen TL, Noebels JL. Arrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death. Sci Transl Med. 2009;1:2ra6.CrossRefPubMedPubMedCentral
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Wandschneider B, Koepp M, Scott C, Micallef C, Balestrini S, Sisodiya SM, et al. Structural imaging biomarkers of sudden unexpected death in epilepsy. Brain. 2015;138:2907–19.CrossRefPubMedPubMedCentral
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Aiba I, Noebels JL. Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models. Sci Transl Med. 2015;7:282ra46.CrossRefPubMedPubMedCentral
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Houser CR, Zhang N, Peng Z, Huang CS, Cetina Y. Neuroanatomical clues to altered neuronal activity in epilepsy: from ultrastructure to signaling pathways of dentate granule cells. Epilepsia. 2012;53(Suppl 1):67–77.CrossRefPubMedPubMedCentral
Metadata
Title
Hippocampal abnormalities and sudden childhood death
Author
Jeffrey Noebels
Publication date
01-06-2016
Publisher
Springer US
Published in
Forensic Science, Medicine and Pathology / Issue 2/2016
Print ISSN: 1547-769X
Electronic ISSN: 1556-2891
DOI
https://doi.org/10.1007/s12024-016-9768-y

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