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01-09-2006 | Original Article

Higher 1,25-dihydroxyvitamin D₃ concentrations associated with lower fall rates in older community-dwelling women

Authors: K. A. Faulkner, J. A. Cauley, J. M. Zmuda, D. P. Landsittel, A. B. Newman, S. A. Studenski, M. S. Redfern, K. E. Ensrud, H. A. Fink, N. E. Lane, M. C. Nevitt

Published in: Osteoporosis International | Issue 9/2006

Abstract

Introduction

The purpose of this study was to examine the relationships of vitamin D supplementation and serum concentrations of vitamin D metabolites and parathyroid hormone (PTH) with neuromuscular function and falls in older community-dwelling women.

Methods

We examined these relationships using a 4-year prospective multi-center study among 9,526 community-dwelling women enrolled in the Study of Osteoporotic Fractures (median age: 70 years; interquartile range: 67–75) and a subset of 389 women (97%) out of 400 who were randomly selected from the entire cohort for serum measures. Measurements included: vitamin D supplementation, serum 25-hydroxyvitamin D₃ [25(OH)D₃], serum 1,25-dihydroxyvitamin D₃ [1,25(OH) ₂D₃], and serum intact parathyroid hormone (iPTH); grip and quadriceps strength, chair-stand time, walking speed, reaction time, and balance-walk time (including changes in grip strength, chair-stand time, walking speed and balance-walk time over approximately 3.7 years); and incident fall rates (number of falls/woman-years).

Results

In 9,526 women, vitamin D supplementation was not associated with any measures of neuromuscular function, change in neuromuscular function, or fall rates (p>0.01 for all). In a subgroup of 389 women, there was a trend of higher 25(OH)D₃ concentration with slightly weaker grip strength (p=0.007), and women in the fourth quartile of 1,25(OH)₂D₃ had a faster chair-stand time (p=0.017) than women in the first quartile; still, in general, concentrations of 25(OH)D₃, 1,25(OH)₂D₃, and iPTH were not associated with either neuromuscular function or changes in neuromuscular function (p>0.05 for all). However, higher 1,25(OH)₂D₃ concentration was associated with lower fall rates (p=0.039).

Conclusions

Higher 1,25(OH)₂D₃ concentration is associated with a lower fall risk in older community-dwelling women, but vitamin D supplementation, and 25(OH)D₃ and iPTH concentrations are not associated with either neuromuscular function or falls.

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Title: Higher 1,25-dihydroxyvitamin D3 concentrations associated with lower fall rates in older community-dwelling women
Authors: K. A. Faulkner
J. A. Cauley
J. M. Zmuda
D. P. Landsittel
A. B. Newman
S. A. Studenski
M. S. Redfern
K. E. Ensrud
H. A. Fink
N. E. Lane
M. C. Nevitt
Publication date: 01-09-2006
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 9/2006
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-006-0071-8

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Springer Medicine

Higher 1,25-dihydroxyvitamin D₃ concentrations associated with lower fall rates in older community-dwelling women

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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