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BMC Cancer
Published in: BMC Cancer 1/2006

Open Access 01-12-2006 | Research article

High Smac/DIABLO expression is associated with early local recurrence of cervical cancer

Authors: Abril Arellano-Llamas, Francisco J Garcia, Delia Perez, David Cantu, Magali Espinosa, Jaime G De la Garza, Vilma Maldonado, Jorge Melendez-Zajgla

Published in: BMC Cancer | Issue 1/2006

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Abstract

Background

In a recent pilot report, we showed that Smac/DIABLO mRNA is expressed de novo in a subset of cervical cancer patients. We have now expanded this study and analyzed Smac/DIABLO expression in the primary lesions in 109 cervical cancer patients.

Methods

We used immunohistochemistry of formalin-fixed, paraffin-embedded tissue sections to analyze Smac/DIABLO expression in the 109 primary lesions. Seventy-eight samples corresponded to epidermoid cervical cancer and 31 to cervical adenocarcinoma. The median follow up was 46.86 months (range 10–186).

Results

Smac/DIABLO was expressed in more adenocarcinoma samples than squamous tumours (71% vs 50%; p = 0.037). Among the pathological variables, a positive correlation was found between Smac/DIABLO immunoreactivity and microvascular density, a marker for angiogenesis (p = 0.04). Most importantly, Smac/DIABLO immunoreactivity was associated with a higher rate of local recurrence in squamous cell carcinoma (p = 0.002, log rank test). No association was found between Smac/DIABLO and survival rates.

Conclusion

Smac/DIABLO expression is a potential marker for local recurrence in cervical squamous cell carcinoma patients.
Appendix
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Metadata
Title
High Smac/DIABLO expression is associated with early local recurrence of cervical cancer
Authors
Abril Arellano-Llamas
Francisco J Garcia
Delia Perez
David Cantu
Magali Espinosa
Jaime G De la Garza
Vilma Maldonado
Jorge Melendez-Zajgla
Publication date
01-12-2006
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2006
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-6-256

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