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01-04-2018 | Original Article

High-resolution language mapping of Broca’s region with transcranial magnetic stimulation

Authors: Katrin Sakreida, Inga Lange, Klaus Willmes, Stefan Heim, Ferdinand Binkofski, Hans Clusmann, Georg Neuloh

Published in: Brain Structure and Function | Issue 3/2018

Abstract

Broca’s region, corresponding roughly to cytoarchitectonic areas 44 and 45 in the inferior frontal cortex, holds a multifunctional role in language processing, as shown, e.g., by functional imaging data. Neuro-navigated transcranial magnetic stimulation (TMS) enables complementary non-invasive mapping of cortical functions with high spatial resolution. Here, we report on detailed TMS language mapping of Broca’s region in 12 healthy participants. The test protocol with an object naming task was adapted for high-resolution and semi-quantitative mapping of TMS-induced effects on speech and language performance. Hierarchical cluster analysis of normalized ratings of error frequency and severity revealed a clear focus of TMS impact at dorso-posterior target sites, close to the inferior frontal junction. Adjacent clusters of moderate and slightly affected stimulation sites yielded a posterosuperior-to-anteroinferior gradient of TMS susceptibility. Our findings indicate that the part of Broca’s region most susceptible to TMS-induced language inhibition in object naming is located in the dorsal area 44.

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Title: High-resolution language mapping of Broca’s region with transcranial magnetic stimulation
Authors: Katrin Sakreida
Inga Lange
Klaus Willmes
Stefan Heim
Ferdinand Binkofski
Hans Clusmann
Georg Neuloh
Publication date: 01-04-2018
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 3/2018
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-017-1550-8

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High-resolution language mapping of Broca’s region with transcranial magnetic stimulation

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