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01-05-2013 | Original Article

High microvessel density in pancreatic ductal adenocarcinoma is associated with high grade

Authors: Anca Barău, Amparo Ruiz-Sauri, Gerardo Valencia, Maria del Carmen Gómez-Mateo, Luis Sabater, Antonio Ferrandez, Antonio Llombart-Bosch

Published in: Virchows Archiv | Issue 5/2013

Abstract

The objectives of this work are to study angiogenesis in pancreatic ductal adenocarcinoma using computerized morphometric and image analysis and to compare the microvascular density in intratumoral and peritumoral areas and normal pancreatic tissue. Microvascular density was analyzed in 60 cases of pancreatic ductal adenocarcinoma and 30 samples of normal pancreatic tissue using an avidin–biotin immunoperoxidase technique with an anti-CD31 antibody. Microvascular density (MVD) was analyzed through digital microimaging and computerized analysis. The blood vessel density in the tumor was significantly higher than in peritumoral areas and in normal pancreatic tissue. Well differentiated pancreatic ductal adenocarcinomas contained higher MVD than poorly differentiated carcinomas. In pancreatic adenocarcinoma, MVD is higher than in peritumoral tissue or normal pancreatic tissue.

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Title: High microvessel density in pancreatic ductal adenocarcinoma is associated with high grade
Authors: Anca Barău
Amparo Ruiz-Sauri
Gerardo Valencia
Maria del Carmen Gómez-Mateo
Luis Sabater
Antonio Ferrandez
Antonio Llombart-Bosch
Publication date: 01-05-2013
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 5/2013
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-013-1409-1

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High microvessel density in pancreatic ductal adenocarcinoma is associated with high grade

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