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BMC Public Health
Published in: BMC Public Health 1/2020

Open Access 01-12-2020 | Research article

High manganese exposure decreased the risk of high triglycerides in workers: a cross-sectional study

Authors: Xiaoyu Luo, Zhenfang Liu, Xiaoting Ge, Sifang Huang, Yanting Zhou, Defu Li, Longman Li, Xiang Chen, Lulu Huang, Qingzhi Hou, Hong Cheng, Lili Xiao, Chaoqun Liu, Yunfeng Zou, Xiaobo Yang

Published in: BMC Public Health | Issue 1/2020

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Abstract

Background

Manganese (Mn) participates in lipid metabolism. However, the associations between Mn exposure and dyslipidaemia is unclear.

Methods

This was a cross-sectional study. Data were collected from the 2017 the Mn-exposed workers healthy cohort (MEWHC). Finally, 803 occupationally Mn-exposed workers included in the study. The workers were divided into two groups. The grouping of this study was based on Mn-Time Weighted Averages (Mn-TWA). The high-exposure group included participants with Mn-TWA greater than 0.15 mg/m3. The low-exposure group included participants with Mn-TWA less than or equal to 0.15 mg/m3. Mn-TWA levels and dyslipidaemia were assessed.

Results

After adjustment for seniority, sex, cigarette consumption, alcohol consumption, high-fat diet frequency, medicine intake in the past two weeks, egg intake frequency, drinking tea, WHR, and hypertension, Mn-TWA levels was negatively correlated with high triglycerides (TG) risk in workers overall (OR = 0.51; 95% CI: 0.36, 0.73; p <  0.01). The results of males and females were consistent (OR = 0.53; 95% CI: 0.34, 0.81; p <  0.01) and (OR = 0.47; 95% CI: 0.24, 0.94; p <  0.01), respectively. By performing interactions analyses of workers overall, we observed no significant interactions among confounders. Mn-TWA levels and pack-years on high TG risk (relative excess risk for the interactions (RERI = 2.29, 95% CI: − 2.07, 6.66), (RERI) = 2.98, 95% CI: − 2.30, 8.26). Similarly, smoking status, drinking status, high-fat diet frequency, and Waist-to-Hip Ratio (WHR) showed non-significant interactions with Mn-TWA levels on high TG risk.

Conclusions

This research indicates that high Mn exposure was negatively related to high TG risk in workers.
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Metadata
Title
High manganese exposure decreased the risk of high triglycerides in workers: a cross-sectional study
Authors
Xiaoyu Luo
Zhenfang Liu
Xiaoting Ge
Sifang Huang
Yanting Zhou
Defu Li
Longman Li
Xiang Chen
Lulu Huang
Qingzhi Hou
Hong Cheng
Lili Xiao
Chaoqun Liu
Yunfeng Zou
Xiaobo Yang
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2020
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-020-09011-x

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