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01-12-2017 | Original Scientific Report

High Expression of Angiopoietin-1 is Associated with Lymph Node Metastasis and Invasiveness of Papillary Thyroid Carcinoma

Authors: Yea Eun Kang, Koon Soon Kim, Sung Jae Park, Seung-Nam Jung, Jae Won Chang, Shinae Yi, Min Gyu Jung, Jin-man Kim, Bon Seok Koo

Published in: World Journal of Surgery | Issue 12/2017

Abstract

Background

We investigated the expression of angiopoietins in patients with papillary thyroid carcinoma (PTC) and the role of angiopoietins as biomarkers predicting the aggressiveness of PTC.

Methods

Expression of angiopoietins was evaluated by immunohistochemistry of tumor specimens from patients with PTC. We demonstrated potential correlations between expression of angiopoietins and clinicopathologic features.

Results

High expression of Ang-1 was positively correlated with a tumor size >1 cm, capsular invasion, extrathyroid extension, lymphovascular invasion, lymph node metastasis, and recurrence (P < 0.05). Moreover, multivariate analysis revealed that high expression of Ang-1 was an independent risk factor for lymph node metastasis (P < 0.001, odds ratio [OR] = 62.113) and lymphovascular invasion (P = 0.027, OR 4.405). However, there was no significant correlation between Ang-2 and clinicopathologic features.

Conclusions

Our results suggest that Ang-1 can serve as a valuable prognostic biomarker for lymph node metastasis and invasiveness in patients with PTC.

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Title: High Expression of Angiopoietin-1 is Associated with Lymph Node Metastasis and Invasiveness of Papillary Thyroid Carcinoma
Authors: Yea Eun Kang
Koon Soon Kim
Sung Jae Park
Seung-Nam Jung
Jae Won Chang
Shinae Yi
Min Gyu Jung
Jin-man Kim
Bon Seok Koo
Publication date: 01-12-2017
Publisher: Springer International Publishing
Published in: World Journal of Surgery / Issue 12/2017
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-017-4111-7

At a glance: The STEP trials

Springer Medicine

High Expression of Angiopoietin-1 is Associated with Lymph Node Metastasis and Invasiveness of Papillary Thyroid Carcinoma

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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