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Published in: Journal of Experimental & Clinical Cancer Research 1/2011

Open Access 01-12-2011 | Research

HIF-1α effects on angiogenic potential in human small cell lung carcinoma

Authors: Jun Wan, Huiping Chai, Zaicheng Yu, Wei Ge, Ningning Kang, Wanli Xia, Yun Che

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2011

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Abstract

Background

Hypoxia-inducible factor-1 alpha (HIF-1α) maybe an important regulatory factor for angiogenesis of small cell lung cancer (SCLC). Our study aimed to investigate the effect of HIF-1α on angiogenic potential of SCLC including two points: One is the effect of HIF-1α on the angiogenesis of SCLC in vivo. The other is the regulation of angiogenic genes by HIF-1α in vitro and in vivo.

Methods

In vivo we used an alternative method to study the effect of HIF-1a on angiogenic potential of SCLC by buliding NCI-H446 cell transplantation tumor on the chick embryo chorioallantoic membrane (CAM) surface. In vitro we used microarray to screen out the angiogenic genes regulated by HIF-1a and tested their expression level in CAM transplantation tumor by RT-PCR and Western-blot analysis.

Results

In vivo angiogenic response surrounding the SCLC transplantation tumors in chick embryo chorioallantoic membrane (CAM) was promoted after exogenous HIF-1α transduction (p < 0.05). In vitro the changes of angiogenic genes expression induced by HIF-1α in NCI-H446 cells were analyzed by cDNA microarray experiments. HIF-1α upregulated the expression of angiogenic genes VEGF-A, TNFAIP6, PDGFC, FN1, MMP28, MMP14 to 6.76-, 6.69-, 2.26-, 2.31-, 4.39-, 2.97- fold respectively and glycolytic genes GLUT1, GLUT2 to2.98-, 3.74- fold respectively. In addition, the expression of these angiogenic factors were also upregulated by HIF-1α in the transplantion tumors in CAM as RT-PCR and Western-blot analysis indicated.

Conclusions

These results indicated that HIF-1α may enhance the angiogenic potential of SCLC by regulating some angiogenic genes such as VEGF-A, MMP28 etc. Therefore, HIF-1α may be a potential target for the gene targeted therapy of SCLC.
Appendix
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Literature
1.
go back to reference Semenza GL, Wang GL: A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol. 1992, 12: 5447-54.PubMedCentralCrossRefPubMed Semenza GL, Wang GL: A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol. 1992, 12: 5447-54.PubMedCentralCrossRefPubMed
2.
go back to reference Wang GL, Jiang BH, Rue EA, Semenza GL: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA. 1995, 92: 5510-4. 10.1073/pnas.92.12.5510.PubMedCentralCrossRefPubMed Wang GL, Jiang BH, Rue EA, Semenza GL: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA. 1995, 92: 5510-4. 10.1073/pnas.92.12.5510.PubMedCentralCrossRefPubMed
3.
go back to reference Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW: Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 1999, 59: 5830-5.PubMed Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW: Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 1999, 59: 5830-5.PubMed
4.
go back to reference Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL: The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol. 2000, 157: 411-21. 10.1016/S0002-9440(10)64554-3.PubMedCentralCrossRefPubMed Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL: The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol. 2000, 157: 411-21. 10.1016/S0002-9440(10)64554-3.PubMedCentralCrossRefPubMed
5.
go back to reference Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW, Semenza GL: Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer. 2000, 88: 2606-18. 10.1002/1097-0142(20000601)88:11<2606::AID-CNCR25>3.0.CO;2-W.CrossRefPubMed Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW, Semenza GL: Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer. 2000, 88: 2606-18. 10.1002/1097-0142(20000601)88:11<2606::AID-CNCR25>3.0.CO;2-W.CrossRefPubMed
6.
go back to reference Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, Oberhuber G: Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res. 2000, 60: 4693-6.PubMed Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, Oberhuber G: Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res. 2000, 60: 4693-6.PubMed
7.
go back to reference Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshert E: Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 1998, 394: 485-90. 10.1038/28867.CrossRefPubMed Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshert E: Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 1998, 394: 485-90. 10.1038/28867.CrossRefPubMed
8.
go back to reference Kimbro KS, Simons JW: Hypoxia-inducible factor-1 in human breast and prostate cancer. Endocr Relat Cancer. 2006, 13: 739-49. 10.1677/erc.1.00728.CrossRefPubMed Kimbro KS, Simons JW: Hypoxia-inducible factor-1 in human breast and prostate cancer. Endocr Relat Cancer. 2006, 13: 739-49. 10.1677/erc.1.00728.CrossRefPubMed
9.
go back to reference Kyzas PA, Stefanou D, Batistatou A, Agnantis NJ: Hypoxia-induced tumor angiogenic pathway in head and neck cancer: an in vivo study. Cancer Lett. 2005, 225: 297-304. 10.1016/j.canlet.2004.11.060.CrossRefPubMed Kyzas PA, Stefanou D, Batistatou A, Agnantis NJ: Hypoxia-induced tumor angiogenic pathway in head and neck cancer: an in vivo study. Cancer Lett. 2005, 225: 297-304. 10.1016/j.canlet.2004.11.060.CrossRefPubMed
10.
go back to reference Ioannou M, Papamichali R, Kouvaras E, Mylonis I, Vageli D, Kerenidou T, Barbanis S, Daponte A, Simos G, Gourgoulianis K, Koukoulis GK: Hypoxia inducible factor-1 alpha and vascular endothelial growth factor in biopsies of small cell lung carcinoma. Lung. 2009, 187: 321-9. 10.1007/s00408-009-9169-z.CrossRefPubMed Ioannou M, Papamichali R, Kouvaras E, Mylonis I, Vageli D, Kerenidou T, Barbanis S, Daponte A, Simos G, Gourgoulianis K, Koukoulis GK: Hypoxia inducible factor-1 alpha and vascular endothelial growth factor in biopsies of small cell lung carcinoma. Lung. 2009, 187: 321-9. 10.1007/s00408-009-9169-z.CrossRefPubMed
11.
go back to reference Litz J, Krystal GW: Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung cancer cells. Mol Cancer Ther. 2006, 5: 1415-22.CrossRefPubMed Litz J, Krystal GW: Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung cancer cells. Mol Cancer Ther. 2006, 5: 1415-22.CrossRefPubMed
12.
go back to reference Lucchi M, Mussi A, Fontanini G, Faviana P, Ribechini A, Angeletti CA: Small cell lung carcinoma (SCLC): the angiogenic phenomenon. Eur J Cardiothorac Surg. 2002, 21: 1105-10. 10.1016/S1010-7940(02)00112-4.CrossRefPubMed Lucchi M, Mussi A, Fontanini G, Faviana P, Ribechini A, Angeletti CA: Small cell lung carcinoma (SCLC): the angiogenic phenomenon. Eur J Cardiothorac Surg. 2002, 21: 1105-10. 10.1016/S1010-7940(02)00112-4.CrossRefPubMed
13.
go back to reference Karnofsky DA, Ridgway LP, Patterson PA: Tumor transplantation to the chick embryo. Ann NY Acad Sci. 1952, 55: 313-29. 10.1111/j.1749-6632.1952.tb26547.x.CrossRefPubMed Karnofsky DA, Ridgway LP, Patterson PA: Tumor transplantation to the chick embryo. Ann NY Acad Sci. 1952, 55: 313-29. 10.1111/j.1749-6632.1952.tb26547.x.CrossRefPubMed
14.
go back to reference Leighton J: Invasion and Metastasis of Heterologous Tumors in the Chick Embryo. Prog Exp Tumor Res. 1964, 4: 98-125.CrossRefPubMed Leighton J: Invasion and Metastasis of Heterologous Tumors in the Chick Embryo. Prog Exp Tumor Res. 1964, 4: 98-125.CrossRefPubMed
15.
go back to reference Weyn B, Tjalma WA, Vermeylen P, van Daele A, Van Marck E, Jacob W: Determination of tumour prognosis based on angiogenesis-related vascular patterns measured by fractal and syntactic structure analysis. Clin Oncol (R Coll Radiol). 2004, 16: 307-16.CrossRef Weyn B, Tjalma WA, Vermeylen P, van Daele A, Van Marck E, Jacob W: Determination of tumour prognosis based on angiogenesis-related vascular patterns measured by fractal and syntactic structure analysis. Clin Oncol (R Coll Radiol). 2004, 16: 307-16.CrossRef
16.
go back to reference Sanz L, Pascual M, Munoz A, Gonzalez MA, Salvador CH, Alvarez-Vallina L: Development of a computer-assisted high-throughput screening platform for anti-angiogenic testing. Microvasc Res. 2002, 63: 335-9. 10.1006/mvre.2001.2389.CrossRefPubMed Sanz L, Pascual M, Munoz A, Gonzalez MA, Salvador CH, Alvarez-Vallina L: Development of a computer-assisted high-throughput screening platform for anti-angiogenic testing. Microvasc Res. 2002, 63: 335-9. 10.1006/mvre.2001.2389.CrossRefPubMed
17.
go back to reference Doukas CN, Maglogiannis I, Chatziioannou AA: Computer-supported angiogenesis quantification using image analysis and statistical averaging. IEEE Trans Inf Technol Biomed. 2008, 12: 650-7.CrossRefPubMed Doukas CN, Maglogiannis I, Chatziioannou AA: Computer-supported angiogenesis quantification using image analysis and statistical averaging. IEEE Trans Inf Technol Biomed. 2008, 12: 650-7.CrossRefPubMed
18.
go back to reference Bobek V, Plachy J, Pinterova D, Kolostova K, Boubelik M, Jiang P, Yang M, Hoffman RM: Development of a green fluorescent protein metastatic-cancer chick-embryo drug-screen model. Clin Exp Metastasis. 2004, 21: 347-52.CrossRefPubMed Bobek V, Plachy J, Pinterova D, Kolostova K, Boubelik M, Jiang P, Yang M, Hoffman RM: Development of a green fluorescent protein metastatic-cancer chick-embryo drug-screen model. Clin Exp Metastasis. 2004, 21: 347-52.CrossRefPubMed
19.
go back to reference Quigley JP, Armstrong PB: Tumor cell intravasation alu-cidated: the chick embryo opens the window. Cell. 1998, 94: 281-4. 10.1016/S0092-8674(00)81470-1.CrossRefPubMed Quigley JP, Armstrong PB: Tumor cell intravasation alu-cidated: the chick embryo opens the window. Cell. 1998, 94: 281-4. 10.1016/S0092-8674(00)81470-1.CrossRefPubMed
20.
go back to reference Mangieri D, Nico B, Coluccia AM, Vacca A, Ponzoni M, Ribatti D: An alternative in vivo system for testing angiogenic potential of human neuroblastoma cells. Cancer Lett. 2009, 277: 199-204. 10.1016/j.canlet.2008.12.014.CrossRefPubMed Mangieri D, Nico B, Coluccia AM, Vacca A, Ponzoni M, Ribatti D: An alternative in vivo system for testing angiogenic potential of human neuroblastoma cells. Cancer Lett. 2009, 277: 199-204. 10.1016/j.canlet.2008.12.014.CrossRefPubMed
21.
go back to reference Jiang M, Wang B, Wang C, He B, Fan H, Guo TB, Shao Q, Gao L, Liu Y: Angiogenesis by transplantation of HIF-1 alpha modified EPCs into ischemic limbs. J Cell Biochem. 2008, 103: 321-34. 10.1002/jcb.21416.CrossRefPubMed Jiang M, Wang B, Wang C, He B, Fan H, Guo TB, Shao Q, Gao L, Liu Y: Angiogenesis by transplantation of HIF-1 alpha modified EPCs into ischemic limbs. J Cell Biochem. 2008, 103: 321-34. 10.1002/jcb.21416.CrossRefPubMed
22.
go back to reference Jiang M, Wang B, Wang C, He B, Fan H, Shao Q, Gao L, Liu Y, Yan G, Pu J: In vivo enhancement of angiogenesis by adenoviral transfer of HIF-1alpha-modified endothelial progenitor cells (Ad-HIF-1alpha-modified EPC for angiogenesis). Int J Biochem Cell Biol. 2008, 40: 2284-95. 10.1016/j.biocel.2008.03.012.CrossRefPubMed Jiang M, Wang B, Wang C, He B, Fan H, Shao Q, Gao L, Liu Y, Yan G, Pu J: In vivo enhancement of angiogenesis by adenoviral transfer of HIF-1alpha-modified endothelial progenitor cells (Ad-HIF-1alpha-modified EPC for angiogenesis). Int J Biochem Cell Biol. 2008, 40: 2284-95. 10.1016/j.biocel.2008.03.012.CrossRefPubMed
23.
go back to reference Wan J, Ma J, Mei J, Shan G: The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells. J Exp Clin Cancer Res. 2009, 28: 150-10.1186/1756-9966-28-150.PubMedCentralCrossRefPubMed Wan J, Ma J, Mei J, Shan G: The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells. J Exp Clin Cancer Res. 2009, 28: 150-10.1186/1756-9966-28-150.PubMedCentralCrossRefPubMed
24.
go back to reference Toyoda E, Doi R, Kami K, Mori T, Ito D, Koizumi M, Kida A, Nagai K, Ito T, Masui T, Wada M, Tagawa M, Uemoto S: Adenovirus vectors with chimeric type 5 and 35 fiber proteins exhibit enhanced transduction of human pancreatic cancer cells. Int J Oncol. 2008, 33: 1141-7.PubMed Toyoda E, Doi R, Kami K, Mori T, Ito D, Koizumi M, Kida A, Nagai K, Ito T, Masui T, Wada M, Tagawa M, Uemoto S: Adenovirus vectors with chimeric type 5 and 35 fiber proteins exhibit enhanced transduction of human pancreatic cancer cells. Int J Oncol. 2008, 33: 1141-7.PubMed
25.
go back to reference Miyagishi M, Hayashi M, Taira K: Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells. Antisense Nucleic Acid Drug Dev. 2003, 13: 1-7. 10.1089/108729003764097296.CrossRefPubMed Miyagishi M, Hayashi M, Taira K: Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells. Antisense Nucleic Acid Drug Dev. 2003, 13: 1-7. 10.1089/108729003764097296.CrossRefPubMed
26.
go back to reference Elson DA, Ryan HE, Snow JW, Johnson R, Arbeit JM: Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res. 2000, 60: 6189-95.PubMed Elson DA, Ryan HE, Snow JW, Johnson R, Arbeit JM: Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res. 2000, 60: 6189-95.PubMed
27.
go back to reference Ryan HE, Poloni M, McNulty W, Elson D, Gassmann M, Arbeit JM, Johnson RS: Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Res. 2000, 60: 4010-5.PubMed Ryan HE, Poloni M, McNulty W, Elson D, Gassmann M, Arbeit JM, Johnson RS: Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Res. 2000, 60: 4010-5.PubMed
28.
go back to reference Chambers AF, Schmidt EE, MacDonald IC, Morris VL, Groom AC: Early steps in hematogenous metastasis of B16F1 melanoma cells in chick embryos studied by high-resolution intravital videomicroscopy. J Natl Cancer Inst. 1992, 84: 797-803. 10.1093/jnci/84.10.797.CrossRefPubMed Chambers AF, Schmidt EE, MacDonald IC, Morris VL, Groom AC: Early steps in hematogenous metastasis of B16F1 melanoma cells in chick embryos studied by high-resolution intravital videomicroscopy. J Natl Cancer Inst. 1992, 84: 797-803. 10.1093/jnci/84.10.797.CrossRefPubMed
29.
go back to reference Brooks PC, Montgomery AM, Rosenfeld M, Reisfeld RA, Hu T, Klier G, Cheresh DA: Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. 1994, 79: 1157-64. 10.1016/0092-8674(94)90007-8.CrossRefPubMed Brooks PC, Montgomery AM, Rosenfeld M, Reisfeld RA, Hu T, Klier G, Cheresh DA: Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. 1994, 79: 1157-64. 10.1016/0092-8674(94)90007-8.CrossRefPubMed
30.
go back to reference Stan AC, Radu DL, Casares S, Bona CA, Brumeanu TD: Antineoplastic efficacy of doxorubicin enzymatically assembled on galactose residues of a monoclonal antibody specific for the carcinoembryonic antigen. Cancer Res. 1999, 59: 115-21.PubMed Stan AC, Radu DL, Casares S, Bona CA, Brumeanu TD: Antineoplastic efficacy of doxorubicin enzymatically assembled on galactose residues of a monoclonal antibody specific for the carcinoembryonic antigen. Cancer Res. 1999, 59: 115-21.PubMed
31.
go back to reference Chen MJ, Chiou PP, Lin P, Lin CM, Siri S, Peck K, Chen TT: Suppression of growth and cancer-induced angiogenesis of aggressive human breast cancer cells (MDA-MB-231) on the chorioallantoic membrane of developing chicken embryos by E-peptide of pro-IGF-I. J Cell Biochem. 2007, 101: 1316-27. 10.1002/jcb.21254.CrossRefPubMed Chen MJ, Chiou PP, Lin P, Lin CM, Siri S, Peck K, Chen TT: Suppression of growth and cancer-induced angiogenesis of aggressive human breast cancer cells (MDA-MB-231) on the chorioallantoic membrane of developing chicken embryos by E-peptide of pro-IGF-I. J Cell Biochem. 2007, 101: 1316-27. 10.1002/jcb.21254.CrossRefPubMed
32.
go back to reference Martinez-Madrid B, Donnez J, Van Eyck AS, Veiga-Lopez A, Dolmans MM, Van Langendonckt A: Chick embryo chorioallantoic membrane (CAM) model: a useful tool to study short-term transplantation of cryopreserved human ovarian tissue. Fertil Steril. 2009, 91: 285-92. 10.1016/j.fertnstert.2007.11.026.CrossRefPubMed Martinez-Madrid B, Donnez J, Van Eyck AS, Veiga-Lopez A, Dolmans MM, Van Langendonckt A: Chick embryo chorioallantoic membrane (CAM) model: a useful tool to study short-term transplantation of cryopreserved human ovarian tissue. Fertil Steril. 2009, 91: 285-92. 10.1016/j.fertnstert.2007.11.026.CrossRefPubMed
33.
go back to reference Namikawa R, Shtivelman E: SCID-hu mice for the study of human cancer metastasis. Cancer Chemother Pharmacol. 1999, S37-41. 43 Suppl Namikawa R, Shtivelman E: SCID-hu mice for the study of human cancer metastasis. Cancer Chemother Pharmacol. 1999, S37-41. 43 Suppl
34.
go back to reference Beasley NJ, Leek R, Alam M, Turley H, Cox GJ, Gatter K, Millard P, Fuggle S, Harris AL: Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Cancer Res. 2002, 62: 2493-7.PubMed Beasley NJ, Leek R, Alam M, Turley H, Cox GJ, Gatter K, Millard P, Fuggle S, Harris AL: Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Cancer Res. 2002, 62: 2493-7.PubMed
35.
go back to reference Volm M, Koomagi R: Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer. Anticancer Res. 2000, 20: 1527-33.PubMed Volm M, Koomagi R: Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer. Anticancer Res. 2000, 20: 1527-33.PubMed
36.
go back to reference Patton JF, Spigel DR, Greco FA, Liggett WH, Zubkus JD, Baskette M, Schreeder M, Woytowitz D, Nelson E, Hainsworth JD: Irinotecan (I), carboplatin (C), and radiotherapy (RT) followed by maintenance bevacizumab (B) in the treatment (tx) of limited-stage small cell lung cancer (LS-SCLC): Update of a phase II trial of the Minnie Pearl Cancer Research Network. Journal of Clinical Oncology. 2006, 24: 385- Patton JF, Spigel DR, Greco FA, Liggett WH, Zubkus JD, Baskette M, Schreeder M, Woytowitz D, Nelson E, Hainsworth JD: Irinotecan (I), carboplatin (C), and radiotherapy (RT) followed by maintenance bevacizumab (B) in the treatment (tx) of limited-stage small cell lung cancer (LS-SCLC): Update of a phase II trial of the Minnie Pearl Cancer Research Network. Journal of Clinical Oncology. 2006, 24: 385-
37.
go back to reference Ramalingam SS, Mack PC, Vokes EE, Longmate J, Govindan R, Koczywas M, Ivy SP, Belani CP, Gandara DR: Cediranib (AZD2171) for the treatment of recurrent small cell lung cancer (SCLC): A California Consortium phase II study (NCI # 7097). J Clin Oncol. 2008, 26: 443- Ramalingam SS, Mack PC, Vokes EE, Longmate J, Govindan R, Koczywas M, Ivy SP, Belani CP, Gandara DR: Cediranib (AZD2171) for the treatment of recurrent small cell lung cancer (SCLC): A California Consortium phase II study (NCI # 7097). J Clin Oncol. 2008, 26: 443-
38.
go back to reference Gitlitz BJ, Glisson BS, Moon J, Reimers H, Gandara DR: Sorafenib in patients with platinum (plat) treated extensive stage small cell lung cancer (E-SCLC): A SWOG (S0435) phase II trial. J Clin Oncol. 2008, 26: 433- Gitlitz BJ, Glisson BS, Moon J, Reimers H, Gandara DR: Sorafenib in patients with platinum (plat) treated extensive stage small cell lung cancer (E-SCLC): A SWOG (S0435) phase II trial. J Clin Oncol. 2008, 26: 433-
39.
go back to reference Schipani E, Maes C, Carmeliet G, Semenza GL: Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF. J Bone Miner Res. 2009, 24: 1347-53. 10.1359/jbmr.090602.PubMedCentralCrossRefPubMed Schipani E, Maes C, Carmeliet G, Semenza GL: Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF. J Bone Miner Res. 2009, 24: 1347-53. 10.1359/jbmr.090602.PubMedCentralCrossRefPubMed
40.
go back to reference Blouw B, Song H, Tihan T, Bosze J, Ferrara N, Gerber HP, Johnson RS, Bergers G: The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell. 2003, 4: 133-46. 10.1016/S1535-6108(03)00194-6.CrossRefPubMed Blouw B, Song H, Tihan T, Bosze J, Ferrara N, Gerber HP, Johnson RS, Bergers G: The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell. 2003, 4: 133-46. 10.1016/S1535-6108(03)00194-6.CrossRefPubMed
41.
go back to reference Michael M, Babic B, Khokha R, Tsao M, Ho J, Pintilie M, Leco K, Chamberlain D, Shepherd FA: Expression and prognostic significance of metalloproteinases and their tissue inhibitors in patients with small-cell lung cancer. J Clin Oncol. 1999, 17: 1802-8.PubMed Michael M, Babic B, Khokha R, Tsao M, Ho J, Pintilie M, Leco K, Chamberlain D, Shepherd FA: Expression and prognostic significance of metalloproteinases and their tissue inhibitors in patients with small-cell lung cancer. J Clin Oncol. 1999, 17: 1802-8.PubMed
42.
go back to reference Shepherd FA, Giaccone G, Seymour L, Debruyne C, Bezjak A, Hirsh V, Smylie M, Rubin S, Martins H, Lamont A, Krzakowski M, Sadura A, Zee B: Prospective, randomized, double-blind, placebo-controlled trial of marimastat after response to first-line chemotherapy in patients with small-cell lung cancer: a trial of the National Cancer Institute of Canada-Clinical Trials Group and the European Organization for Research and Treatment of Cancer. J Clin Oncol. 2002, 20: 4434-9. 10.1200/JCO.2002.02.108.CrossRefPubMed Shepherd FA, Giaccone G, Seymour L, Debruyne C, Bezjak A, Hirsh V, Smylie M, Rubin S, Martins H, Lamont A, Krzakowski M, Sadura A, Zee B: Prospective, randomized, double-blind, placebo-controlled trial of marimastat after response to first-line chemotherapy in patients with small-cell lung cancer: a trial of the National Cancer Institute of Canada-Clinical Trials Group and the European Organization for Research and Treatment of Cancer. J Clin Oncol. 2002, 20: 4434-9. 10.1200/JCO.2002.02.108.CrossRefPubMed
43.
go back to reference Lohi J, Wilson CL, Roby JD, Parks WC: Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. J Biol Chem. 2001, 276: 10134-44. 10.1074/jbc.M001599200.CrossRefPubMed Lohi J, Wilson CL, Roby JD, Parks WC: Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. J Biol Chem. 2001, 276: 10134-44. 10.1074/jbc.M001599200.CrossRefPubMed
44.
go back to reference Illman SA, Lehti K, Keski-Oja J, Lohi J: Epilysin (MMP-28) induces TGF-beta mediated epithelial to mesenchymal transition in lung carcinoma cells. J Cell Sci. 2006, 119: 3856-65. 10.1242/jcs.03157.CrossRefPubMed Illman SA, Lehti K, Keski-Oja J, Lohi J: Epilysin (MMP-28) induces TGF-beta mediated epithelial to mesenchymal transition in lung carcinoma cells. J Cell Sci. 2006, 119: 3856-65. 10.1242/jcs.03157.CrossRefPubMed
45.
go back to reference Koh MY, Spivak-Kroizman TR, Powis G: HIF-1alpha and cancer therapy. Recent Results Cancer Res. 2010, 180: 15-34. 10.1007/978-3-540-78281-0_3.CrossRefPubMed Koh MY, Spivak-Kroizman TR, Powis G: HIF-1alpha and cancer therapy. Recent Results Cancer Res. 2010, 180: 15-34. 10.1007/978-3-540-78281-0_3.CrossRefPubMed
46.
go back to reference Cenni E, Perut F, Granchi D, Avnet S, Amato I, Brandi ML, Giunti A, Baldini N: Inhibition of angiogenesis via FGF-2 blockage in primitive and bone metastatic renal cell carcinoma. Anticancer Res. 2007, 27: 315-9.PubMed Cenni E, Perut F, Granchi D, Avnet S, Amato I, Brandi ML, Giunti A, Baldini N: Inhibition of angiogenesis via FGF-2 blockage in primitive and bone metastatic renal cell carcinoma. Anticancer Res. 2007, 27: 315-9.PubMed
47.
go back to reference Xue Y, Cao R, Nilsson D, Chen S, Westergren R, Hedlund EM, Martijn C, Rondahl L, Krauli P, Walum E, Enerback S, Cao Y: FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue. Proc Natl Acad Sci USA. 2008, 105: 10167-72. 10.1073/pnas.0802486105.PubMedCentralCrossRefPubMed Xue Y, Cao R, Nilsson D, Chen S, Westergren R, Hedlund EM, Martijn C, Rondahl L, Krauli P, Walum E, Enerback S, Cao Y: FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue. Proc Natl Acad Sci USA. 2008, 105: 10167-72. 10.1073/pnas.0802486105.PubMedCentralCrossRefPubMed
48.
go back to reference Boddy JL, Fox SB, Han C, Campo L, Turley H, Kanga S, Malone PR, Harris AL: The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer. Clin Cancer Res. 2005, 11: 7658-63. 10.1158/1078-0432.CCR-05-0460.CrossRefPubMed Boddy JL, Fox SB, Han C, Campo L, Turley H, Kanga S, Malone PR, Harris AL: The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer. Clin Cancer Res. 2005, 11: 7658-63. 10.1158/1078-0432.CCR-05-0460.CrossRefPubMed
49.
go back to reference Wisniewski HG, Vilcek J: Cytokine-induced gene expression at the crossroads of innate immunity, inflammation and fertility: TSG-6 and PTX3/TSG-14. Cytokine Growth Factor Rev. 2004, 15: 129-46. 10.1016/j.cytogfr.2004.01.005.CrossRefPubMed Wisniewski HG, Vilcek J: Cytokine-induced gene expression at the crossroads of innate immunity, inflammation and fertility: TSG-6 and PTX3/TSG-14. Cytokine Growth Factor Rev. 2004, 15: 129-46. 10.1016/j.cytogfr.2004.01.005.CrossRefPubMed
50.
go back to reference Bellehumeur C, Blanchet J, Fontaine JY, Bourcier N, Akoum A: Interleukin 1 regulates its own receptors in human endometrial cells via distinct mechanisms. Hum Reprod. 2009, 24: 2193-204. 10.1093/humrep/dep192.CrossRefPubMed Bellehumeur C, Blanchet J, Fontaine JY, Bourcier N, Akoum A: Interleukin 1 regulates its own receptors in human endometrial cells via distinct mechanisms. Hum Reprod. 2009, 24: 2193-204. 10.1093/humrep/dep192.CrossRefPubMed
51.
go back to reference Saidi A, Hagedorn M, Allain N, Verpelli C, Sala C, Bello L, Bikfalvi A, Javerzat S: Combined targeting of interleukin-6 and vascular endothelial growth factor potently inhibits glioma growth and invasiveness. Int J Cancer. 2009, 125: 1054-64. 10.1002/ijc.24380.CrossRefPubMed Saidi A, Hagedorn M, Allain N, Verpelli C, Sala C, Bello L, Bikfalvi A, Javerzat S: Combined targeting of interleukin-6 and vascular endothelial growth factor potently inhibits glioma growth and invasiveness. Int J Cancer. 2009, 125: 1054-64. 10.1002/ijc.24380.CrossRefPubMed
52.
go back to reference Albini A, Tosetti F, Benelli R, Noonan DM: Tumor inflammatory angiogenesis and its chemoprevention. Cancer Res. 2005, 65: 10637-41. 10.1158/0008-5472.CAN-05-3473.CrossRefPubMed Albini A, Tosetti F, Benelli R, Noonan DM: Tumor inflammatory angiogenesis and its chemoprevention. Cancer Res. 2005, 65: 10637-41. 10.1158/0008-5472.CAN-05-3473.CrossRefPubMed
53.
go back to reference Kenji K, Hironori U, Hideya Y, Michinori I, Yasuhiko H, Nobuoki K: Tenascin-C is associated with coronary plaque instability in patients with acute coronary syndromes. Circ J. 2004, 68: 198-203. 10.1253/circj.68.198.CrossRefPubMed Kenji K, Hironori U, Hideya Y, Michinori I, Yasuhiko H, Nobuoki K: Tenascin-C is associated with coronary plaque instability in patients with acute coronary syndromes. Circ J. 2004, 68: 198-203. 10.1253/circj.68.198.CrossRefPubMed
54.
go back to reference Tonini T, Rossi F, Claudio PP: Molecular basis of angiogenesis and cancer. Oncogene. 2003, 22: 6549-56. 10.1038/sj.onc.1206816.CrossRefPubMed Tonini T, Rossi F, Claudio PP: Molecular basis of angiogenesis and cancer. Oncogene. 2003, 22: 6549-56. 10.1038/sj.onc.1206816.CrossRefPubMed
55.
go back to reference Sass G, Leukel P, Schmitz V, Raskopf E, Ocker M, Neureiter D, Meissnitzer M, Tasika E, Tannapfel A, Tiegs G: Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice. Int J Cancer. 2008, 123: 1269-77. 10.1002/ijc.23695.CrossRefPubMed Sass G, Leukel P, Schmitz V, Raskopf E, Ocker M, Neureiter D, Meissnitzer M, Tasika E, Tannapfel A, Tiegs G: Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice. Int J Cancer. 2008, 123: 1269-77. 10.1002/ijc.23695.CrossRefPubMed
56.
go back to reference Sunamura M, Duda DG, Ghattas MH, Lozonschi L, Motoi F, Yamauchi J, Matsuno S, Shibahara S, Abraham NG: Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer. Angiogenesis. 2003, 6: 15-24. 10.1023/A:1025803600840.CrossRefPubMed Sunamura M, Duda DG, Ghattas MH, Lozonschi L, Motoi F, Yamauchi J, Matsuno S, Shibahara S, Abraham NG: Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer. Angiogenesis. 2003, 6: 15-24. 10.1023/A:1025803600840.CrossRefPubMed
57.
go back to reference Torisu-Itakura H, Furue M, Kuwano M, Ono M: Co-expression of thymidine phosphorylase and heme oxygenase-1 in macrophages in human malignant vertical growth melanomas. Jpn J Cancer Res. 2000, 91: 906-10.CrossRefPubMed Torisu-Itakura H, Furue M, Kuwano M, Ono M: Co-expression of thymidine phosphorylase and heme oxygenase-1 in macrophages in human malignant vertical growth melanomas. Jpn J Cancer Res. 2000, 91: 906-10.CrossRefPubMed
Metadata
Title
HIF-1α effects on angiogenic potential in human small cell lung carcinoma
Authors
Jun Wan
Huiping Chai
Zaicheng Yu
Wei Ge
Ningning Kang
Wanli Xia
Yun Che
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2011
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/1756-9966-30-77

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