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Clinical Oral Investigations

Published in:

01-11-2013 | Short Communication

Herpes simplex virus reactivation and dental procedures

Authors: L. El Hayderi, P. Delvenne, E. Rompen, J. M. Senterre, A. F. Nikkels

Published in: Clinical Oral Investigations | Issue 8/2013

Abstract

Objectives

Dental extraction is reported to trigger recurrent herpes labialis (RHL).

Aim

This aims to prospectively study the clinical occurrence of RHL and the oral herpes simplex virus type 1 (HSV-1) viral shedding before and 3 days after different dental procedures.

Materials and methods

Oral HSV-1 DNA was measured by real-time PCR before and 3 days after dental procedures of the inferior dentition in 57 immunocompetent patients (mean age 32.4 years) who were selected and divided into four distinct subgroups (dental inspection without anesthesia, n = 19; dental filling under local anesthesia, n = 14; molar extraction under local anesthesia, n = 15; and molar extraction under general anesthesia, n = 9) and compared to 32 healthy controls (mean age 33 years).

Results

None of the patients suffered from RHL at day 3. Oral HSV-1 DNA was detected before and after procedure in 1.7 % (1/57) and 5.3 % (3/57), respectively [dental inspection without anesthesia, 5.3 % (1/19); molar extraction under local anesthesia, 6.7 % (1/15); and molar extraction under general anesthesia, 11 % (1/9)]. None of the controls presented RHL or detectable oral HSV-1 DNA. There was no statistically significant difference between the study groups and controls.

Conclusion

Molar extraction increases the risk of oral HSV-1 shedding but not of RHL. Procedure-related nerve damage probably accounts for HSV reactivation.

Clinical relevance

Antiviral prophylaxis for RHL is not routinely recommended for dental procedures, regardless of a prior history of RHL.

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Title: Herpes simplex virus reactivation and dental procedures
Authors: L. El Hayderi
P. Delvenne
E. Rompen
J. M. Senterre
A. F. Nikkels
Publication date: 01-11-2013
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 8/2013
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-013-0986-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Herpes simplex virus reactivation and dental procedures

Abstract

Objectives

Aim

Materials and methods

Results

Conclusion

Clinical relevance

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Aim

Materials and methods

Results

Conclusion

Clinical relevance

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