Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Hernia
Published in: Hernia 6/2006

01-12-2006 | Review

Hernia disease and collagen gene regulation: are there clues for intervention?

Authors: Petra Lynen Jansen, Uwe Klinge, Peter R. Mertens

Published in: Hernia | Issue 6/2006

Login to get access

Abstract

Collagens belong to the most abundant proteins in the body. After tissue injury, a coordinated regulation of collagen gene expression guides the formation of a provisional matrix that subsequently evolves into a mature scar with tensile strength. In the following, knowledge regarding collagen gene regulation that may provide insight into how to specifically address the biological problem of soft tissue weakness and recurrent hernia disease is summarized.
Literature
1.
Junge K, Klinge U, Rosch R, Mertens PR, Kirch J, Klosterhalfen B, Lynen P, Schumpelick V (2004) Decreased collagen type I/III ratio in patients with recurring hernia after implantation of alloplastic prostheses. Langenbecks Arch Surg 389:17–22PubMedCrossRef
2.
Klinge U, Si ZY, Zheng H, Schumpelick V, Bhardwaj RS, Klosterhalfen B (2000) Abnormal collagen I to III distribution in the skin of patients with incisional hernia. Eur Surg Res 32:43–48PubMedCrossRef
3.
Taniguchi S, Ueda K, Inoue T, Li TS, Kuga T, Hamano K (2006) Impact of collagen subtype proportions in peritoneal tissues on inguinal hernia formation in adults and infants. Pediatr Surg Int 22:600–604PubMedCrossRef
4.
5.
Silver FH, Christiansen DL, Snowhill PB, Chen Y (2000) Role of storage on changes in the mechanical properties of tendon and self-assembled collagen fibers. Connect Tissue Res 41:155–164PubMed
6.
Linsenmayer TF, Fitch JM, Birk DE (1990) Heterotypic collagen fibrils and stabilizing collagens. Controlling elements in corneal morphogenesis? Ann NY Acad Sci 580:143–160CrossRef
7.
Ninomiya Y, Olsen BR (1984) Synthesis and characterization of cDNA encoding a cartilage-specific short collagen. Proc Natl Acad Sci USA 81:3014–3018PubMedCrossRef
8.
Kuivaniemi H, Tromp G, Prockop DJ (1997) Mutations in fibrillar collagens (types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels. Hum Mutat 9:300–315PubMedCrossRef
9.
Menashi S, Campa JS, Greenhalgh RM, Powell JT (1987) Collagen in abdominal aortic aneurysm: typing, content, and degradation. J Vasc Surg 6:578–582PubMedCrossRef
10.
Lehnert B, Wadouh F (1992) High coincidence of inguinal hernias and abdominal aortic aneurysms. Ann Vasc Surg 6:134–137PubMedCrossRef
11.
Mautner J, Behrends U, Hortnagel K, Brielmeier M, Hammerschmidt W, Strobl L, Bornkamm GW, Polack A (1996) c-myc expression is activated by the immunoglobulin kappa-enhancers from a distance of at least 30 kb but not by elements located within 50 kb of the unaltered c-myc locus in vivo. Oncogene 12:1299–1307PubMed
12.
Yamada Y, Ando F, Niino N, Shimokata H (2005) Association of a -1997G–>T polymorphism of the collagen Ialpha1 gene with bone mineral density in postmenopausal Japanese women. Hum Biol 77:27–36PubMedCrossRef
13.
Si Z, Bhardwaj R, Rosch R, Mertens PR, Klosterhalfen B, Klinge U, Rhanjit B, Rene PM (2002) Impaired balance of type I and type III procollagen mRNA in cultured fibroblasts of patients with incisional hernia. Surgery 131:324–331PubMedCrossRef
14.
Mertens PR, Harendza S, Pollock AS, Lovett DH (1997) Glomerular mesangial cell-specific transactivation of matrix metalloproteinase 2átranscription is mediated by YB-1. J Biol Chem 272:22905–22912PubMedCrossRef
15.
Mertens PR, Steinmann K, Alfonso-Jaume MA, En-Nia A, Sun Y, Lovett DH (2002) Combinatorial interactions of p53, AP2 and YB-1 with a single enhancer element regulate gelatinase a expression in neoplastic cells. J Biol Chem 277: 24875-24882PubMedCrossRef
16.
Cutroneo KR (2003) How is type I procollagen synthesis regulated at the gene level during tissue fibrosis. J Cell Biochem 90:1–5PubMedCrossRef
17.
18.
Overall CM, Lopez-Otin C (2002) Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer 2:657–672PubMedCrossRef
19.
Chakraborti S, Mandal M, Das S, Mandal A, Chakraborti T (2003) Regulation of matrix metalloproteinases: an overview. Mol Cell Biochem 253:269–285PubMedCrossRef
20.
Kleiner DE Jr, Stetler-Stevenson WG (1993) Structural biochemistry and activation of matrix metalloproteases. Curr Opin Cell Biol 5:891–897PubMedCrossRef
21.
Harendza S, Pollock AS, Mertens PR, Lovett DH (1995) Tissue-specific enhancer-promoter interactions regulate high level constitutive expression of matrix metalloproteinase 2 by glomerular mesangial cells. J Biol Chem 270:18786–18796PubMedCrossRef
22.
Marti HP, McNeil L, Davies M, Martin J, Lovett DH (1993) Homology cloning of rat 72 kDa type IV collagenase: cytokine and second-messenger inducibility in glomerular mesangial cells. Biochem J 291:441–446PubMed
23.
Overall CM, Wrana JL, Sodek J (1989) Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. J Biol Chem 264:1860–1869PubMed
24.
Norman JT, Lindahl GE, Shakib K, En-Nia A, Yilmaz E, Mertens PR (2001) The Y-box binding protein YB-1 suppresses collagen alpha 1(I) gene transcription via an evolutionarily conserved regulatory element in the proximal promoter. J Biol Chem 276:29880–29890PubMedCrossRef
25.
Peltonen L, Halila R, Ryhanen L (1985) Enzymes converting procollagens to collagens. J Cell Biochem 28:15–21PubMedCrossRef
26.
Kirsch E, Ihme A, Muller P, Krieg T (1982) Molecular defects in inborn disorders of collagen metabolism. Enzyme 27:239–258PubMed
27.
Matskevichus ZK (1987) Mechanisms and role of collagen biodegradation in pathology. Arkh Patol 49:3–10PubMed
28.
Vogel S, Volk HW, Wasmer HP, Buchwald J (1991) Treatment of iatrogenic esophageal perforation. Zentralbl Chir 116:751–756PubMed
29.
Yin L, Morita A, Tsuji T (2000) Alterations of extracellular matrix induced by tobacco smoke extract. Arch Dermatol Res 292:188–194PubMedCrossRef
30.
Jesmin S, Sakuma I, Hattori Y, Kitabatake A (2003) Role of angiotensin II in altered expression of molecules responsible for coronary matrix remodeling in insulin-resistant diabetic rats. Arterioscler Thromb Vasc Biol 23:2021–2026PubMedCrossRef
31.
Prockop DJ, Kadler KE, Hojima Y, Constantinou CD, Dombrowski KE, Kuivaniemi H, Tromp G, Vogel B (1988) Expression of type I procollagen genes. Ciba Found Symp 136:142–160PubMed
Metadata
Title
Hernia disease and collagen gene regulation: are there clues for intervention?
Authors
Petra Lynen Jansen
Uwe Klinge
Peter R. Mertens
Publication date
01-12-2006
Publisher
Springer-Verlag
Published in
Hernia / Issue 6/2006
Print ISSN: 1265-4906
Electronic ISSN: 1248-9204
DOI
https://doi.org/10.1007/s10029-006-0147-6

Other articles of this Issue 6/2006

Hernia 6/2006 Go to the issue

Review

Collagenase and surgical disease

Introduction

Introduction

Review

Modification of collagen formation using supplemented mesh materials

Review

Radiation responses in skin and connective tissues: effect on wound healing and surgical outcome

Editorial

Special issue—Collagen

Review

Are collagens the culprits in the development of incisional and inguinal hernia disease?