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01-02-2019 | Invited Review

Heritable traits that contribute to nephrolithiasis

Authors: John C. Lieske, Xiangling Wang

Published in: Urolithiasis | Issue 1/2019

Abstract

Urinary stones tend to cluster in families. Of the known risk factors, evidence is strongest for heritability of urinary calcium excretion. Recent studies suggest that other stone risk factors may have heritable components including urinary pH, citrate and magnesium excretion, and circulating vitamin D concentration. Several risk factors assumed purely environmental may also have heritable components, including dietary intake and thirst. Thus, future studies may reveal that genetics plays an even stronger role in urinary stone pathogenesis than previously known.

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Title: Heritable traits that contribute to nephrolithiasis
Authors: John C. Lieske
Xiangling Wang
Publication date: 01-02-2019
Publisher: Springer Berlin Heidelberg
Published in: Urolithiasis / Issue 1/2019
Print ISSN: 2194-7228
Electronic ISSN: 2194-7236
DOI: https://doi.org/10.1007/s00240-018-1095-1

At a glance: The STEP trials

Springer Medicine

Heritable traits that contribute to nephrolithiasis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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