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Comparative Clinical Pathology
Published in: Comparative Clinical Pathology 4/2019

01-08-2019 | Original Article

Hepatoprotective potential of aqueous extract of Allium eriophyllum Boiss in high-fat diet-induced fatty liver diseases

Authors: Samaneh Goorani, Mohsen Zhaleh, Majid Hajialiani, Rohallah Moradi, Mohammad Kazem Koohi, Khodabakhsh Rashidi, Mohammad Mahdi Zangeneh, Akram Zangeneh

Published in: Comparative Clinical Pathology | Issue 4/2019

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Abstract

In recent years, Iranian traditional medicine has been used to control, prevent, and treat various diseases such as fatty liver. One of these plants is Allium eriophyllum Boiss. In this research, we assessed the potential of aqueous extract of A. eriophyllum in the treatment of fatty liver disease in Wistar male rats. At beginning of the study, a total of 10 rats were selected as the negative control, and 50 rats were treated with a high-fat diet for 4 months. Then, the animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, and four groups receiving the aqueous extract of A. eriophyllum at 25, 50, 100, and 200 mg/kg concentrations. After 2 months, the rats were sacrificed, and blood and liver samples were collected. The data were analyzed by SPSS 21 software. All groups of A. eriophyllum (especially A200) could significantly (p ≤ 0.05) decrease the raised weights of body and liver and the concentrations of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, glucose, and GR and increase the concentrations of HDL, total protein, albumin, SOD, CAT, and GPx as compared to the untreated group. Also, A. eriophyllum (especially A200) decreased the degree of hepatic steatosis as compared to the untreated group. In finally, it appears that the aqueous extract of A. eriophyllum can treat the fatty liver disease in rats.
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Metadata
Title
Hepatoprotective potential of aqueous extract of Allium eriophyllum Boiss in high-fat diet-induced fatty liver diseases
Authors
Samaneh Goorani
Mohsen Zhaleh
Majid Hajialiani
Rohallah Moradi
Mohammad Kazem Koohi
Khodabakhsh Rashidi
Mohammad Mahdi Zangeneh
Akram Zangeneh
Publication date
01-08-2019
Publisher
Springer London
Published in
Comparative Clinical Pathology / Issue 4/2019
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI
https://doi.org/10.1007/s00580-018-2853-8

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