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01-07-2007 | Case Report

Hepatoportal venopathy due to disseminated Mycobacterium avium complex infection in a child with IFN-γ receptor 2 deficiency

Authors: Amy V. Rapkiewicz, Smita Y. Patel, Steven M. Holland, David E. Kleiner

Published in: Virchows Archiv | Issue 1/2007

Abstract

The control of intracellular microorganisms such as mycobacteria is largely dependent on the adaptive immune response, specifically the interaction of T helper cells and antigen presenting cells such as macrophages. The interferon gamma (IFN-γ) pathway activation is crucial for containment and killing of mycobacteria, as evidenced by the fact that defects in this pathway often result in profound infections with both tuberculous and non-tuberculous mycobacteria. We herein report a case of a child with autosomal recessive IFN-γ receptor 2 (IFN-γR2) deficiency who developed hepatic venopathy secondary to disseminated Mycobacterium avium complex (MAC) infection.

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Title: Hepatoportal venopathy due to disseminated Mycobacterium avium complex infection in a child with IFN-γ receptor 2 deficiency
Authors: Amy V. Rapkiewicz
Smita Y. Patel
Steven M. Holland
David E. Kleiner
Publication date: 01-07-2007
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 1/2007
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-007-0427-2

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Hepatoportal venopathy due to disseminated Mycobacterium avium complex infection in a child with IFN-γ receptor 2 deficiency

Abstract

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Abstract

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